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2017 Vol. 40, No. 2
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2017, 40(2): 127-128.
doi: 10.3969/j.issn.1674-4500.2017.02.01
Abstract:
Objective To assess patients' satisfaction level with orthodontic treatment and to identify it there was any association between patient's reason to seek orthodontic treatment and their satisfaction level with the treatment outcome. Methods This study was conducted among a sample of 80 patients. A questionnaire was formulated including Dental Impact on Daily Living questionnaire (to assess the effect of the treatment on daily living and satisfaction with the dentition). Descriptive statistics, Chi-square test were used to analyze the data. Results and Conclusion Patients' reason to seek orthodontic treatment had no significant association with patients' satisfaction with their dentition after orthodontic treatment. Patients with aesthetic need were found to experience more pain (P=0.034). There was statistical significant association between age and total satisfaction (P=0.035). Gender had no effect on patient's satisfaction.
2017, 40(2): 129-132.
doi: 10.3969/j.issn.1674-4500.2017.02.02
Abstract:
Objective To study the risk factors and prevention strategies of endoscopic resection of colorectal polyps delayed bleeding. Methods A total of 3157 patients who cured in my hospital endoscopic resection of colorectal polyps from July 2013 to June 2015 were chosed. Then we investigated the patient-related factors, the polyps related factors and some other relevant factors, at the same time.We measured each patient's diastolic blood pressure, systolic blood pressure and polyp diameter.Risk factors of delayed postoperative bleeding were screened and prevention measures summarized. Results Delayed bleeding occurred in 27/3157 patients (0.86%). Delayed bleeding was identified from 5 to 7 days after resection (mean, 5.9±1.8 days). The mean age was 57.8±3.4 years, and the average polyp size was 32.1±3.7 mm.Univariate analysis showed that, compared with the patient who was not bleeding, bleeding patients with high blood pressure, age, polyps diameter and shape were significant different (P<0.05). The multivariate regression analysis showed that high blood pressure, age, polyps position were independent risk factors (P<0.05). Conclusion High blood pressure, age, polyps position are independent risk factor for postoperative delayed bleeding, clinical should focus attention.
2017, 40(2): 133-136.
doi: 10.3969/j.issn.1674-4500.2017.02.03
Abstract:
Objective To investigate the significance of ultrasound in the diagnosis of DDH. Methods The hip joints (117) in all DDH patients (117) were examined by ultrasound and MRI to compare the consistency of the results between the two methods. The classification was made according to the pathological degree. The consistence of the diagnosis results was compared in the two testing methods and patients in different ages. Results The diagonsis of ultrasound were consistent with that of MRI in the the results of bony structure (the ilium, the top of acetabulum and the femoral head ) of hip joints ( K=0.901-0.885, P＜0.001). The diagonses of ultrasound and MRI have less consistence in the results of top of acetabulum cartilage lesions (K=0.093, P=0.151), in the glenoid labrum (K=0.188, P=0.108), and joint capsule (K=0.201, P=0.095) of hip joints in DDH patients. Additionally, the diagonsis of ultrasound were consistent with that of MRI in the results of hypogenetic hip joints (GrafⅡa type、Ⅱb typ and MRIⅠtype) (K=0.963, P<0.001), and in the complete hip joint dislocation (GrafⅢ type、Ⅳ type and MRIⅢ type) (K=0.897, P<0.001). The diagonses of ultrasound and MRI have less consistence in the results of incomplete hip joint dislocation (GrafⅡc type、D type and MRIⅡ type) (K=0.152, P=0.093). Finally, the diagonsis of ultrasound were consistent with that of MRI in the patients within 6 months (K=0.819, P<0.001). The diagonses of ultrasound and MRI have less consistence in the patients older than 6 months (K=0.136, P=0.202). Conclusion It is important to use DDH in early DDH for this method is benifit for follow-up observation and clinical treatment guidence.
Objective To investigate the significance of ultrasound in the diagnosis of DDH. Methods The hip joints (117) in all DDH patients (117) were examined by ultrasound and MRI to compare the consistency of the results between the two methods. The classification was made according to the pathological degree. The consistence of the diagnosis results was compared in the two testing methods and patients in different ages. Results The diagonsis of ultrasound were consistent with that of MRI in the the results of bony structure (the ilium, the top of acetabulum and the femoral head ) of hip joints ( K=0.901-0.885, P＜0.001). The diagonses of ultrasound and MRI have less consistence in the results of top of acetabulum cartilage lesions (K=0.093, P=0.151), in the glenoid labrum (K=0.188, P=0.108), and joint capsule (K=0.201, P=0.095) of hip joints in DDH patients. Additionally, the diagonsis of ultrasound were consistent with that of MRI in the results of hypogenetic hip joints (GrafⅡa type、Ⅱb typ and MRIⅠtype) (K=0.963, P<0.001), and in the complete hip joint dislocation (GrafⅢ type、Ⅳ type and MRIⅢ type) (K=0.897, P<0.001). The diagonses of ultrasound and MRI have less consistence in the results of incomplete hip joint dislocation (GrafⅡc type、D type and MRIⅡ type) (K=0.152, P=0.093). Finally, the diagonsis of ultrasound were consistent with that of MRI in the patients within 6 months (K=0.819, P<0.001). The diagonses of ultrasound and MRI have less consistence in the patients older than 6 months (K=0.136, P=0.202). Conclusion It is important to use DDH in early DDH for this method is benifit for follow-up observation and clinical treatment guidence.
2017, 40(2): 137-140.
doi: 10.3969/j.issn.1674-4500.2017.02.04
Abstract:
Objectives To investigate the feasibility and safety of ovarian endometriosis cyst removal surgery injecting hemabate into myometrium in laparoscopy. Methods A total of 68 patients with laparoscopic ovarian endometriosis cyst stripping were enrolled into the study from houjie hospital. They were freely classified into two groups, and 31 patients injected hemabate into myometrium (study group), and 37 patients did not use hemabate (control group). The operative time, intraoperative blood loss, blood pressure, postoperative change of hemoglobin, surgical complications and postoperative highest temperature of the two groups were compared. Results The average operative time of study group was 107.7±13.2 min, and the average blood loss during the operation was 114.7±28.1 mL. The average operative time of control group was 126.1±16.0 min, and the average blood loss during the operation was 188.6±57.4 mL, the difference was statistically significant (P<0.05). The rate of the postoperative change of hemoglobin in study group was significantly less than that in control group (P<0.05). The average postoperative highest temperature of study group was 36.9±0.43 ℃, the average postoperative exhaust time was 18.9±4.56 h, and the average postoperative hospitalization time was 7.1±0.79 d. The average postoperative highest temperature of control group was 36.7±0.42 ℃, the average postoperative exhaust time was 19.3±4.40 h, and the average postoperative hospitalization time was 7.3±0.96 d, the difference was not statistically significant (P>0.05). But few patients of study group had a transient high blood pressure. No significant differences existed surgical complications (P>0.05). Conclusion Using hemabate of ovarian endometriosis cyst surgery in laparoscopy can reduce intraoperative bleeding and postoperative complications, and shorten operation time. It is a safe and feasible method for intraoperative medication in laparoscopy.
2017, 40(2): 141-143.
doi: 10.3969/j.issn.1674-4500.2017.02.05
Abstract:
Objective To explore the value ofapparent diffusion coefficient (ADC) parameters in benign, malignant tumor diagnosis and differential value. Methods A total of 48 patients were choosed as research object, who accepted for diagnosis and treatment from February 2015~2016 year in May in our hospital with diagnosised of benign and malignant tumor. Benign group had 20 patients with benign tumor, malignant group included 28 patients with malignant tumor. Magnetic resonance imaging in patients with 2 groups related data were retrospectively analyzed. Results The patients with benign group tumor-like lesions DWI signal were exist diversity. They were characterized by high, high, such as signal. DWI signal malignanted patients lesions characterized by high signal. ADC values in malignant group was significantly lower than that of benign group (P<0.05). Conclusion ADC values of pelvic lesions shows a higher sensitivity. The value for pelvic early clinical differential diagnosis of benign and malignant tumor to provide reliable reference basis.
2017, 40(2): 144-147.
doi: 10.3969/j.issn.1674-4500.2017.02.06
Abstract:
Objective To evaluate the MSCT value in diagnosing the fracture of femoral neck. Methods The MSCT and clinical features of 102 cases with fracture of femoral neck were analyzed retrospectively. Results Sixteen cases were fracture of subcapital type, 24 cases were fracture of cervical type, 62 cases were fracture of basilar type. 18 cases were fracture of subcapital Garden Ⅰ, 59 cases were fracture of subcapital Garden Ⅱ, 19 cases were fracture of subcapital Garden Ⅲ, 6 cases were fracture of subcapital Garden IV. 3 cases of secondary ischemic necrosis. Conclusion Transcervical fracture can be diagnosed by MSCT comprehensively and accurately, which has important significance for the treatment and prognosis of the patients.
2017, 40(2): 148-151.
doi: 10.3969/j.issn.1674-4500.2017.02.07
Abstract:
Objective To explore the clinical value of DCE-MR in astrocytoma diagnosis and differential diagnosis. Methods The magnetic resonance examination were performed in 60 cases of patients (Male 32, Female 28) with suspend of brain tumors by GE Signa HDxT 3.0T (GE medical system, Milwaukee) after the administration of Omniscan at the flow rate of 3 mL/s, 0.1 mmol/kg. The ROI was automatically selected by the OK software, three slides were measured. The measurement was trying to avoid blood vessels and artifacts. The Ktrans, Kep and Ve were calculated and the average value was taken. Results Tumor was found in 35 patients, 28 of them underwent surgery and biopsy, 14 astrocytomas, 3 meningiomas, 3 ependymomas, 4 metastases, 2 craniopharyngiomas and 2 acoustic neuroma. The pathological results showed that 3 of 14 astrocytomas were grade I, 4 were grade II, 4 were grade III and 3 were grade IV. Both values of high grade gliomas include grade Ⅲ and Ⅳ were significantly higher than that of low grade gliomas include gradeⅠ and Ⅱ (P<0.05). There was no statistically difference of the parameters of Ktrans and Ve values between grades Ⅰ with Ⅱ and grade Ⅲ with Ⅳ (P>0.05). Conclusion Quantitative DCE-MR parameters Ktrans, Kep and Ve value can be used to distinguish low grade and high grade astrocytoma, and evaluate the possibility of recurrence, plays an important role in discriminate different grade intracranial tumors in a preoperative noninvasive way.
2017, 40(2): 152-154.
doi: 10.3969/j.issn.1674-4500.2017.02.08
Abstract:
Objective To make logistic regression for factors resulting in postoperative knee pain edema for patients underwent synovectomy via arthroscopy. Methods A retrospective analysis was made and 31 of pain in the knee was recorded the arthroscopic case. Thirty-eight knee operation and the patient's own were caused as two factors, and assignment for dual factors, dual by Logistic regression analysis to compare the influence of above factors on the complications. Results By 5 step regression, five factors with the "planning machine faults in ligaments, into the road is not accurate and rinses extravasation into the soft tissue around the knee joint, the articular cavity clearance too narrow, merging, systemic disease" were found as the factors relating to postoperative pain in the knee joint . Conclusion The combined systemic disease and patients with articular cavity gap too narrow, the downward arthroscopic synovectomy should be on the premise of selecting the right surgical approach, timely adsorption rinses, and carefully to avoid injured ligaments.
Objective To make logistic regression for factors resulting in postoperative knee pain edema for patients underwent synovectomy via arthroscopy. Methods A retrospective analysis was made and 31 of pain in the knee was recorded the arthroscopic case. Thirty-eight knee operation and the patient's own were caused as two factors, and assignment for dual factors, dual by Logistic regression analysis to compare the influence of above factors on the complications. Results By 5 step regression, five factors with the "planning machine faults in ligaments, into the road is not accurate and rinses extravasation into the soft tissue around the knee joint, the articular cavity clearance too narrow, merging, systemic disease" were found as the factors relating to postoperative pain in the knee joint . Conclusion The combined systemic disease and patients with articular cavity gap too narrow, the downward arthroscopic synovectomy should be on the premise of selecting the right surgical approach, timely adsorption rinses, and carefully to avoid injured ligaments.
2017, 40(2): 158-160.
doi: 10.3969/j.issn.1674-4500.2017.02.10
Abstract:
Objective To analyze the levels of D-dimer and fibrinogen in plasma of patients with different types of orthopedic diseases, and to explore the tendency of patients with different types of orthopedic disorders complicated with thrombotic diseases. Methods The measured results of D-dimer, FIB, PT, APTT, TT, WBC and PLT were compared in patients with different types of orthopedic diseases. Results The measured results and rate of abnormality of D-dimer in all groups were the highest.The second was FIB.From higher to lower in turn for group of femoral fracture, thoracic vertebr and lumbar vertebral fracture, other fracture, cervical vertebra and lumbar disc herniation, the joint disease.Compared with healthy control group, the measured results and rate of abnormality of D-dimer and FIB were significant different. The rate of abnormality of D-dimer in the group of femoral fracture was 100%, thoracic vertebr and lumbar vertebral fracture 94%, other fracture 88.23%, the joint disease 64.56%, cervical vertebra and lumbar disc herniation 62.63%. Conclusion In addition to fracture and surgery patients with significant increase in D-dimer, the other types of orthopedic disorders in patients with plasma D-dimer levels and FIB are generally increased.It means that patients with different orthopedic disorders have thrombotic disease tendencies, close observation of D-dimer and FIB levels, alert to the occurrence of deep vein thrombosis.
2017, 40(2): 161-166.
doi: 10.3969/j.issn.1674-4500.2017.02.11
Abstract:
Objective To reconstruct the middle ear structure in three-dimensional by Micro-CT data, and explore the motion rule of chain ossicles and tympanic membrane vibration characteristics in biomechanical theory research by using the finite element method. Methods The model was verified correctly by comparing finite element simulation data with experimental data about the amplitude of tympanic membrane umbo and stapes footplate. The conclusion was drawn by frequency response analysis and modal analysis. Results (1) The vibration and rotation of ossicular chain were different under various frequencies. Three ossicles performed rotating and rocking motion around axis of rotation. Manubrium mallei close to tympanic membrane umbo performed in same phase rotation and translation. Stapes footplate performed translation like the piston. (2) At the frequency of 1000 Hz, the total bending deformation of tympanic membrane ran up to 2.32e-006 m, which appeared in annular ligament of tympanic membrane. The maximum deformation of the membrane tympani umbo was about 1.0e-007 m. Under the excitation of sound pressure, the annular ligament of tympanic membrane was prone to distortion. The stress concentration occurred in the vicinity of membrane tympani umbo.The maximum stress was 8.33e-004 MPa. Conclusion Motion of ossicular chain will provide theoretical guidance for life science research and clinical operation of human ears.
2017, 40(2): 167-169.
doi: 10.3969/j.issn.1674-4500.2017.02.12
Abstract:
Objective To compare the reliability of arterial blood gas, blood glucose and peripheral blood glucose in critically ill patients with ICU, and analyze the related factors of variation of glucose values of the two measurement. Methods Fourty ICU critical patients were selected.In the morning, two kinds of blood samples, i.e.arterial blood and capillary blood, were collected and tested at the same time. Results Arterial blood glucose and capillary blood glucose showed a strong correlation with venous blood glucose (r=0.952, P<0.001)．The mean difference (bias) was significant (P<0.005) for arterial blood glucose and venous blood glucose.The diffence blood glucose values of two blood glucose measurement was influenced by the status of peripheral circulation of finger tips. Conclusion Reliablity of the blood glucose values of capillary blood need further study in critical patients.the status of peripheral circulation of finger tips is one influencing factor of capillary blood values.
2017, 40(2): 170-174.
doi: 10.3969/j.issn.1674-4500.2017.02.13
Abstract:
Objective To observe the effect of exocarpium on TGF-β1/Smad signal pathway in diabetic cardiomyopathy (DCM) rat myocardial cells. Methods 1) To construct the model of DCM rats, 40 rats were treated with streptozotocin, 15 rats with blood glucose <16.7 mmol/L were in blank control group. The remaining 25 rats with blood glucose >16.7 mmol/L were randomly divided into diabetic cardiomyopathy group (DCM group, n=11) and exocarpium group (n=14). Rats of exocarpium group were given exocarpium [400 mg/(kg·d)], DCM group and control group were given normal saline. Different time of blood glucose (1, 8, 16, 22 weeks) were measured.Heart function index measurement, myocardial morphological changes were observed under light microscope.Quantitative analysis of myocardial fibrosis was performed by electron microscopy. Myocardial collagen amount, myocardial collagen content was determined by immunohistochemistry. Western blot detection of myocardial protein of TGF-β1, Smad, MMP-9, MMP-2, TIMP-1 and RT-PCR detection of mRNA of TGF-β1, MMP-9, MMP-2, TIMP-1.2) To construct the myocardial fibroblast proliferation model.All were randomly divided into two groups, there is serum medium with 0.5 mmol L-1 exocarpium in exocarpium pretreatment group, while the control group with serum medium. To detect two groups of NO changes, TGF-β1 protein, c-fos protein, p27 protein, iNOS protein, the expression of Cyclin D protein. Results Compared with DCM group, each time point of blood glucose, myocardial fibrosis, myocardial collagen and the total collagen were significantly decreased and systolic, diastolic function improved significantly In exocarpium groups (P<0.05). TGF-β1, Smad, MMP-9, MMP-2, TIMP-1 protein expression were significantly reduced in exocarpium groups (P<0.05). Protein mRNA expression was significantly inhibited in exocarpium groups (P<0.05). Compared with control group, NO, TGF-β1 protein, c-fos protein, p27 protein, iNOS protein, Cyclin D protein decreased significantly in pretreatment group (P<0.05). Conclusion Exocarpium on TGF-β1/Smad pathway in diabetic cardiomyopathy performs an effect of inhibitory. It regulates downstream MMPs/TIMPs pathway, improve myocardial fibrosis, inhibit myocardial hypertrophy and reduce myocardial injury.
2017, 40(2): 175-178.
doi: 10.3969/j.issn.1674-4500.2017.02.14
Abstract:
Objective To observe the clinical efficacy of PPH & plication operation of rectal mucosa and sphincter in the treatment of mild rectal prolapse. Methods A total of 60 rectal prolapse patients were randomly divided into the treatment group (30 patients) and the control group (30 patients). The treatment group was treated with PPH & plication operation of rectal mucosa and sphincter while the control group was treated with traditional surgery. Curative effects, recurrence rate and complication were investigated in these two groups. Results There was significant difference in average curative effects, operation duration, postoperation pain, wound healing time, blood loss during operation, hospital stays, uroschesis, infection, recurrence rate between the treatment group and the control group (P<0.05). Anal function had a good recovery after operation. Conclusion PPH & plication operation of rectal mucosa and sphincter is effective in treatment of mild rectal prolapse, which is worthy of clinic applications.
2017, 40(2): 179-182.
doi: 10.3969/j.issn.1674-4500.2017.02.15
Abstract:
Objeetive To evaluate the effect of combination therapy of toherodine and tamsulosin in improving symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods A total of 64 patients with CP/CPPS in our hospital were randomized into control group and observation group, with 32 cases in each group. The control group was treated with tamsulosin (2 mg, qd), while the observation group was treated with tamsulosin (2 mg, qd) combined with tolterodine (4 mg, qd). Chronic prostatitis symptom index (CPSI), Visual analogue scale (VAS), maximum flow rate (MFR), average flow rate (AFR), white blood cell (WBC) of ESP were compared before treatment and after 12 weeks. The patients’ compliance in two groups’ patients was investigated as well. Results After treatment, The observation group have decreased in NIH-CPSI (16.34±4.31), VAS (4.22±1.70), WBC (7.16±3.35), urinary symptom score (2.78±1.56), QOL (5.44±2.23) and Morisky (0.84±0.85). MFR (19.47±4.69)、AFR (11.91±3.85) were significantly increased, and the indexes were better than control group (24.16±4.95、6.34±1.62、14.78±4.64、5.78±2.09、8.41±2.67、1.22±0.67).The difference was statistically significant (P<0.05). Conclusion Combination therapy of toherodine and tamsulosin is better than tamsulosin hydrochloride alone in treatment of CP/CPPS.
2017, 40(2): 183-185.
doi: 10.3969/j.issn.1674-4500.2017.02.16
Abstract:
Objective To explore the application of early tracheotomy combined with gastrostomy on the prognosis for patients with severe craniocerebral injury. Methods Fifty-one cases of severe craniocerebral injury, who received early tracheotomy combined with gatsrostomy, were enrolled as the observation group.The other 61 cases who only received arly tracheotomy but without gatsrostomy were enrolled as the control group. The rates of pneumonia infection after 2 weeks and the GCS scoring were compared. Results At 2 weeks after operation, the incidence of pulmonary infection in the observation group was significantly lower than that in the control group. Pulmonary infection had a positive correlation with nutriture.When discharging,most of the GCS scores were greater than 8. The patients who scored <8 of GCS between the groups was significant. Conclusion The early tracheotomy and gatsrostomy after severe craniocerebral injury surgeryhe manage respiratory track well and it improves pulmonary infection, intensify nutrition suppot and improve rehabilitation of cerebral function.
Objective To explore the application of early tracheotomy combined with gastrostomy on the prognosis for patients with severe craniocerebral injury. Methods Fifty-one cases of severe craniocerebral injury, who received early tracheotomy combined with gatsrostomy, were enrolled as the observation group.The other 61 cases who only received arly tracheotomy but without gatsrostomy were enrolled as the control group. The rates of pneumonia infection after 2 weeks and the GCS scoring were compared. Results At 2 weeks after operation, the incidence of pulmonary infection in the observation group was significantly lower than that in the control group. Pulmonary infection had a positive correlation with nutriture.When discharging,most of the GCS scores were greater than 8. The patients who scored <8 of GCS between the groups was significant. Conclusion The early tracheotomy and gatsrostomy after severe craniocerebral injury surgeryhe manage respiratory track well and it improves pulmonary infection, intensify nutrition suppot and improve rehabilitation of cerebral function.
2017, 40(2): 186-189.
doi: 10.3969/j.issn.1674-4500.2017.02.17
Abstract:
Objective To evaluate the therapeutic effect of total laparoscopic selective pericardial devascularization without splenectomy. Methods The clinical data of 11 patients who received total laparoscopic selective pericardial devascularization without splenectomy from Feb 2011 to Dec 2014 were retrospectively analyzed. The blood routine, hepatic function, blood coagulation function, perioperative compliations, operation time and amount of bleeding were observed. The patients were followed-up and the re-bleeding rate and survival rate were observed. Results All of the 11 operations were completed successfully under laparoscope. The mean operation time was 157 min (ranged from 110 to 225 min). The mean intraoperative blood loss was 83 ml (ranged from 30 to 150 ml). The mean postoperative hospital stay was 9.4 days(ranged from 5 to 14 days). There was no significant difference in the levels of the leukocyte, platelet, hemoglobin, total billrubin, albumin and blood coagulation function between pre- and a week after postoperative (P>0.05). Conclusion Total laparoscopic selective pericardial devascularization without splenectomy is a safe and effective method for treatment of portal hypertension with upper gastrointestinal hemorrhage.
2017, 40(2): 190-193.
doi: 10.3969/j.issn.1674-4500.2017.02.18
Abstract:
Objective To study the serum homocysteine (Hcy) level in diabetic nephropathy patients and the its correlation of the inflammatory factors. Methods From February 2012 to August 2012, a total of 160 patients with type 2 diabetic nephropathy were selected in our hospital, according to the urinary albumin excretion rate and serum creatinine level, which is divided into diabetes mellitus group (DM group), early diabetic nephropathy (EDN) group, diabetic nephropathy group (CDN) and renal failure (CRF) group, 40 cases of healthy physical examination as the control group, comparing the patients’ Hcy level and their biochemical index in the five group patients, to analyze the correlation between the Hcy level and the inflammatory factor, such as IL-6, IL-1 TNF-α and hsCRP. Results GLU、HbA1c、UREA、Cr、TP、ALB、TCH and TG in the five group patients had no significant difference (P<0.01), the five patients of Hcy comparative differences were statistically significant (F=27.452,P<0.01), the inflammation indicator in the five patients, including hsCRP, TNF-α, IL-1 and IL-6 comparison had significant difference (P<0.01), the serum Hcy levels had significant positive correlation with hsCRP (r=0.624, P<0.01), the serum Hcy levels had significant positive correlation with TNF-α (r=0.557, P<0.01), the serum Hcy levels had significant positive correlation with IL-1 (r=0.568, P<0.01), serum Hcy levels had significant positive correlation with IL-6 (r=0. 417, P=0.017). Conclusion Hcy plays a great important role in the progression of diabetic nephropathy, it can be used as the important indexes for evaluation of renal vascular injury and disease progression in DN patients, and has significant positive correlation with hsCRP, IL-1, IL 6 and TNF-α.
2017, 40(2): 194-196.
doi: 10.3969/j.issn.1674-4500.2017.02.19
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Objective To test serum level of interleukin 18(IL-18), matrix metalloproteinases-2(MMP-2) and its organization inhibitors (TIMP-2) in children with Henoch Schonlcin purpura(HSP), and then discuss the relationship to kidney damage. Methods Fifty-eight cases were divided into pure purpura of 30 cases, merger of renal damage group of 28 cases according to the clinical urine test results, and healthy controls of 20 cases. Serum level of IL-18, MMP-2 and TIMP-2 were detected respectively using double antibody enzyme linked sandwich immunoassay method (ELISA). Results The content of 3 items in pure purpura group and merger renal damage group were significantly higher than that in the health control group. The content of IL-18(t=8.55, P<0.05), MMP-2(t=10.36, P<0.05) in merger renal damage group is higher than in the pure purpura group. But there was no significant difference between the pure purpura group and the merger renal damage group comparing the content of TIMP-2(t=2.69, P>0.05). Conclusion The contents of IL-18, MMP-2 and TIMP-2 in blood of children with Henoch-Schonlcin purpura are higher. IL-18 and MMP-2 are relationship to the patient's kidney damage.
Objective To test serum level of interleukin 18(IL-18), matrix metalloproteinases-2(MMP-2) and its organization inhibitors (TIMP-2) in children with Henoch Schonlcin purpura(HSP), and then discuss the relationship to kidney damage. Methods Fifty-eight cases were divided into pure purpura of 30 cases, merger of renal damage group of 28 cases according to the clinical urine test results, and healthy controls of 20 cases. Serum level of IL-18, MMP-2 and TIMP-2 were detected respectively using double antibody enzyme linked sandwich immunoassay method (ELISA). Results The content of 3 items in pure purpura group and merger renal damage group were significantly higher than that in the health control group. The content of IL-18(t=8.55, P<0.05), MMP-2(t=10.36, P<0.05) in merger renal damage group is higher than in the pure purpura group. But there was no significant difference between the pure purpura group and the merger renal damage group comparing the content of TIMP-2(t=2.69, P>0.05). Conclusion The contents of IL-18, MMP-2 and TIMP-2 in blood of children with Henoch-Schonlcin purpura are higher. IL-18 and MMP-2 are relationship to the patient's kidney damage.
2017, 40(2): 197-198.
doi: 10.3969/j.issn.1674-4500.2017.02.20
Abstract:
Objective To analyze the characteristics of the proportion of the adenovirus infection in children with asthmatic bronchitis in different ages, and to guide the clinical diagnosis and treatment. Methods A total of 1132 cases from January 2014 to July 2016 in Qingyuan City People's Hospital pediatrics outpatient and emergency department or hospital treatment were chosed, with clinical and chest X-ray diagnosis for children of asthmatic bronchitis. According to ages,they were divided into 5 groups (<6 months, ≥6 months and <1 year old, ≥1 year old and <3 years old, ≥3 years of age and <6 years old, ≥6 years old and <14 years old), respectively according to the detection of respiratory viruses and they were recorded each adenovirus positive cases, calculate the positive rate of adenovirus and were given statistical analysis. Results Significant differences were found in the positive rate of each group of adenovirus. Adenovirus positive rate in group of ≥6 years old and <14 years old was the highest (x 2=35.216, P=0.000). Conclusion The highest proportion of the adenovirus infection in children with asthmatic bronchitis were in the ages of ≥6 years old and <14 years old group (elder age group), which in clinical diagnosis should be paid attention.
2017, 40(2): 199-201.
doi: 10.3969/j.issn.1674-4500.2017.02.21
Abstract:
Objective To investigate the interventional therapy and the long-term efficacy of conservative treatment of acute myocardial infarction. Methods A total of 100 cases of patients with acute myocardial infarction in August 2013-August 2013 at our hospital were retrospectively group studed. Conservative groups were performed with conservative treatment; intervention group were taken intervention treatment. We compared two groups of patients with anterior wall myocardial infarction and inferior wall myocardial infarction, 1 year survival rate, incidence of cardiac events, and hospitalization rates; Before and after treatment 1 year cardiac function classification. Results In intervention group of patients with anterior wall myocardial infarction, 1 year survival rate significantly higher than the conservative group, incidence of cardiac events, and hospitalization rates were significantly lower than the conservative group (P<0.05). In two groups of patients with inferior wall myocardial infarction, 1 year survival rate, incidence of cardiac events, and hospitalization rates had no significant differences (P>0.05). Two groups before treatment in patients with cardiac function classification had no significant difference (P>0.05). In intervention group of anterior wall myocardial infarction, cardiac function 1 year after treatment grade were significant better than the conservative group (P<0.05). In two groups of inferior wall myocardial infarction, cardiac function 1 year after treat-ment grading were significantly improved, with no significant difference between groups (P>0.05). Conclusion Interventional treatment and conservative treatment of acute inferior wall myocardial infarction, the long-term efficacy of similar, but the long-term efficacy of anterior wall myocardial infarction, the effectiveness of interventional treatment is better.It can improve the survival rate, reduce the incidence of adverse cardiac events and hospitalization rates.It improves cardiac function in patients, which is worth promoting.
2017, 40(2): 202-206.
doi: 10.3969/j.issn.1674-4500.2017.02.22
Abstract:
Objective To unravel the differences of biological characteristics and the uderlying molecular mechanisms between different passages of U87 glioblastoma cell line. Methods U87 (I) and U87 (II), with less or more passage number respectively, were established examined separately by MTT assay, transwell chamber assay, boyden chamber assay. Western blot was used to analyze the expression of CTHRC1, FOXM1, PLOD2, MMP9, TGF-β, E-cadherin, Slug, Snail, Vimentin, PI3K, p-PI3K, Akt and p-Akt separately in these two types of cells. Results Compared to U87 (II), U87 (I) was more prone to form tubules and showed more invasiveness, while there were no differences between U87 (I) and U87 (II) in proliferation and migration. The expression of markers of EMT varies in these two types of cells, with more expression of E-cadherin and Slug and less expression of Vimentin and Snail in U87 (II). Moreover, U87 (II) was found to have greater amount of Akt and p-Akt, but have smaller amount of p-PI3k. No significant difference was found on the expression of PI3K between these cells. Additionally, the expression of PLO2, CTHRC1 and MMP9 were higher in U87 (I) than that in U87 (II), while the expression of TGF-β in U87 (I) was lower than that in the latter one. Conclusion As the passage number increased, U87 cell lines exhibited changes in invasiveness as well as some oncogenic genes’ expressions. It may lead to the different results during different periods, making the results inconvincible. Together, our results showed that, to lessen the influence of passage numbers on cells’ biological characteristics, scientists should use cells with same passage numbers and finish the experiments as quickly as they can.
2017, 40(2): 207-209.
doi: 10.3969/j.issn.1674-4500.2017.02.23
Abstract:
Objective To study the effect of melatonin on the expression of estrogen receptor in rats breast cancer, and to analyze the role of melatonin in the development of breast cancer. Methods Ninety female rats of clean grade SD in age 2 months were selected, and the breast cancer cells were inoculated in the rats. The rats were randomly divided to control group injected with saline, group injected with melatonin at a dose of 7.5 mg/(kg·d), group injected with melatonin at a dose of 15 mg/(kg·d). The breast cancer tumor bearing models of rats were established on the 10th day after inoculating, and the tissues of breast cancer were taken out. The expression of estrogen receptor in breast cancer was detected by immunohistochemistry method. Results The estrogen receptor expression index of rats breast cancer tissues in the group injected with melatonin was lower than that in the control group injected with saline, the estrogen receptor expression index further decreased with the increase of the dose of melatonin. Above differences were statistically significant. Conclusion Melatonin can inhibit the expression of estrogen receptor in breast cancer tissues, which may be one of the ways to prevent the development of breast cancer.
Objective To study the effect of melatonin on the expression of estrogen receptor in rats breast cancer, and to analyze the role of melatonin in the development of breast cancer. Methods Ninety female rats of clean grade SD in age 2 months were selected, and the breast cancer cells were inoculated in the rats. The rats were randomly divided to control group injected with saline, group injected with melatonin at a dose of 7.5 mg/(kg·d), group injected with melatonin at a dose of 15 mg/(kg·d). The breast cancer tumor bearing models of rats were established on the 10th day after inoculating, and the tissues of breast cancer were taken out. The expression of estrogen receptor in breast cancer was detected by immunohistochemistry method. Results The estrogen receptor expression index of rats breast cancer tissues in the group injected with melatonin was lower than that in the control group injected with saline, the estrogen receptor expression index further decreased with the increase of the dose of melatonin. Above differences were statistically significant. Conclusion Melatonin can inhibit the expression of estrogen receptor in breast cancer tissues, which may be one of the ways to prevent the development of breast cancer.
2017, 40(2): 214-219.
doi: 10.3969/j.issn.1674-4500.2017.02.25
Abstract:
2017, 40(2): 220-224.
doi: 10.3969/j.issn.1674-4500.2017.02.26
Abstract:
With the rapid development of modern science and technology, developmental neurobiology has been rapid development in twenty-first Century, people pay more and more attention to the subject of this research. SCIE, CPCI and CNKI as the data source,we used to retrieve on developmental neurobiology issued in recent 47 years in China and abroad.Then we used thomson data analyzer (TDA), Microsoft Office Excel 2010 tools to map and analysis the data, summarize the bibliometrics of SCI, CPCI in developmental neurobiology field of international and China.We gave some suggests to developmental neurobiology research field of China.It needs to continue to strengthen the research, improve the quantity and quality of the paper and cooperate with powerful counntry, organization and author.We will reinforce our own ability to apply for key sponsored project and continuely focus on hot-topic and recent development of subjects. Meanwhile, according to developmental neurobiolog、expression、ergastrics keyword , we can closely follow such involving study field and its latest development.
With the rapid development of modern science and technology, developmental neurobiology has been rapid development in twenty-first Century, people pay more and more attention to the subject of this research. SCIE, CPCI and CNKI as the data source,we used to retrieve on developmental neurobiology issued in recent 47 years in China and abroad.Then we used thomson data analyzer (TDA), Microsoft Office Excel 2010 tools to map and analysis the data, summarize the bibliometrics of SCI, CPCI in developmental neurobiology field of international and China.We gave some suggests to developmental neurobiology research field of China.It needs to continue to strengthen the research, improve the quantity and quality of the paper and cooperate with powerful counntry, organization and author.We will reinforce our own ability to apply for key sponsored project and continuely focus on hot-topic and recent development of subjects. Meanwhile, according to developmental neurobiolog、expression、ergastrics keyword , we can closely follow such involving study field and its latest development.
2017, 40(2): 225-228.
doi: 10.3969/j.issn.1674-4500.2017.02.27
Abstract:
Objective To investigate the quality of teaching information obesity and bariatric surgery on mobile medical Apps in China. Summarizes the quality of teaching information on mobile medical Apps whether meet the needs of patients. Methods We searched the key words " Yi” on the platform of " Apple store”, " Yingyongbao” and downloaded 63 related Apps. After screening, a total of 28 Apps’ related teaching information were evaluated using " Silberg scale” and " Abott scale”. Comparing with the same scores of the foreign medical Apps, evaluate the quality of teaching information obesity and bariatric surgery on mobile medical Apps in China. Results A total of 28 Apps’ teaching information were evaluated, the mean score of " Silberg scale” was 2.96±.96l. The mean score of " Abott scale” was 1.61±0.61. The score for the " Quality of content” was 3.85±1.76. The quality of teaching information obesity and bariatric surgery is poor. It was lacked of sufficient accuracy and authority. The content was not that specific. More, the information was lacked of timely updating and modification. Conclusion The mobile medical Apps in China are supposed to improve the veracity and authority of teaching information. Especially in terms of author authentication, information source, information renew and modification of teaching information.
2017, 40(2): 229-232.
doi: 10.3969/j.issn.1674-4500.2017.02.28
Abstract:
Chinese special national conditions and the health needs of the people at present stage made sickbeds increase rapidly. Pathologists had a huge gap. Many medical colleges or universities set clinical pathology for the undergraduate or master’ students in line with medical market and heath needs. But these college were lack of appropriate facilities and training base . The students after graduation could not be well adapted to clinical work. Pathology training base was the most important place to performed pathology practice teaching and training for students’ practical skills. According to the needs of clinical pathology specialty and other specialties course, Southern Medical University unified the university, enterprise and hospital to build a pathology training that covering teaching, research and practice or service which called integrated school- hospital-enterprise pathology training base.
Chinese special national conditions and the health needs of the people at present stage made sickbeds increase rapidly. Pathologists had a huge gap. Many medical colleges or universities set clinical pathology for the undergraduate or master’ students in line with medical market and heath needs. But these college were lack of appropriate facilities and training base . The students after graduation could not be well adapted to clinical work. Pathology training base was the most important place to performed pathology practice teaching and training for students’ practical skills. According to the needs of clinical pathology specialty and other specialties course, Southern Medical University unified the university, enterprise and hospital to build a pathology training that covering teaching, research and practice or service which called integrated school- hospital-enterprise pathology training base.
2017, 40(2): 233-234.
doi: 10.3969/j.issn.1674-4500.2017.02.29
Abstract:
2017, 40(2): 235-238.
doi: 10.3969/j.issn.1674-4500.2017.02.30
Abstract:
Objective To compare the effects of three kinds of traditional Chinese medicine external treatment on hypertension patients with insomnia. Methods Ninety patients with hypertension and insomnia were randomly divided into lavipeditum group, acupoint application of chinese herb group, lavipeditum combined with acupoint application of chinese herb group, 30 patients in each group. Three groups of patients were treated every night for 1 time, 7 days for 1 course in a total of 4 courses. According to the Pittsburgh sleep quality index to evaluate the treatment effect. Results After 4 courses of treatment,compared to the acupoint application of chinese herb group, lavipeditum group did not show Significant differences on curative effect (include sleep preparation time and the actual sleep time) (P>0.05); After 2 treatment intervention, the sleep quality (include sleep time of preparation, the actual sleep time) of 3 groups of patients showed improvement trend, but there was no Significant differences (P>0.05). After third courses of treatment intervention, on 21 days and 28 days, the curative effect (include sleep time of preparation, the actual sleep time) of lavipeditum combined with acupoint application of chinese herb group was greater than the other 2 groups . The difference was significant between the groups (P<0.05). Conclusion Three kinds of traditional Chinese medicine external treatment can improve sleep quality of hypertension patients with insomnia.Lavipeditum combined with acupoint application of chinese herb can improve hypertension patients with insomnia sleep quality more effectively.
Objective To compare the effects of three kinds of traditional Chinese medicine external treatment on hypertension patients with insomnia. Methods Ninety patients with hypertension and insomnia were randomly divided into lavipeditum group, acupoint application of chinese herb group, lavipeditum combined with acupoint application of chinese herb group, 30 patients in each group. Three groups of patients were treated every night for 1 time, 7 days for 1 course in a total of 4 courses. According to the Pittsburgh sleep quality index to evaluate the treatment effect. Results After 4 courses of treatment,compared to the acupoint application of chinese herb group, lavipeditum group did not show Significant differences on curative effect (include sleep preparation time and the actual sleep time) (P>0.05); After 2 treatment intervention, the sleep quality (include sleep time of preparation, the actual sleep time) of 3 groups of patients showed improvement trend, but there was no Significant differences (P>0.05). After third courses of treatment intervention, on 21 days and 28 days, the curative effect (include sleep time of preparation, the actual sleep time) of lavipeditum combined with acupoint application of chinese herb group was greater than the other 2 groups . The difference was significant between the groups (P<0.05). Conclusion Three kinds of traditional Chinese medicine external treatment can improve sleep quality of hypertension patients with insomnia.Lavipeditum combined with acupoint application of chinese herb can improve hypertension patients with insomnia sleep quality more effectively.
2017, 40(2): 239-241.
doi: 10.3969/j.issn.1674-4500.2017.02.31
Abstract:
Objective To compare the clinical effectiveness of the combination of moist exposed burn ointment (MEBO) and supportive care and skin barrier cream on the hand-foot syndrome(HFS) in patients treated with capecitabine. Methods A total of 119 patients from Nanfang hospital were randomly divided into treatment group and control group. Patients in control group were applied skin barrier cream and traditional skin care, while those of trentment group were treated with MEBO and supportive care. Results Compared with the control group, patients of the treatment group had a lower severity and incidence of HFS (P<0.05). It also had an effective ratio as well. Conclusion MEBO and supportive care decrease the severity and incidence of HFS caused by capectitabine more effectively compared with skin barrier cream.
Objective To compare the clinical effectiveness of the combination of moist exposed burn ointment (MEBO) and supportive care and skin barrier cream on the hand-foot syndrome(HFS) in patients treated with capecitabine. Methods A total of 119 patients from Nanfang hospital were randomly divided into treatment group and control group. Patients in control group were applied skin barrier cream and traditional skin care, while those of trentment group were treated with MEBO and supportive care. Results Compared with the control group, patients of the treatment group had a lower severity and incidence of HFS (P<0.05). It also had an effective ratio as well. Conclusion MEBO and supportive care decrease the severity and incidence of HFS caused by capectitabine more effectively compared with skin barrier cream.
2017, 40(2): 242-244.
doi: 10.3969/j.issn.1674-4500.2017.02.32
Abstract:
Objective To study the application of delicacy management using for hemodialysis patients out of hospital Methods The delicacy management was applied to manage hemodialysis patients out of hospital to improve the implementation of Self-care and improve their health out of hospital. A total of 180 hemodialysis patients were divided into comparison group and test group, with 90 cases in each group. The comparison group were performed normal health education,the test group were controlled standardized, specialized, standardized, systematic and meticulous management. Results Six months later,infection complication rate of test group was significantly lower than that of comparison group, the self-care ability was significantly higher than that of comparison group. Conclusion The quality of care outside the hospital of hemodialysis patients who was performed delicacy management is much higher than the normal health educated one.It can significantly improve the health status of the patient.
