Risk factors of delayed bleeding after endoscopic resection of colorectal polyps
-
摘要:
目的 研究内镜下大肠息肉切除术后迟发性出血的危险因素。 方法 选择2013年7月~2015年6月在我院行内镜下大肠息肉切除术的3157例患者,并对其相关危险因素、息肉相关因素及治疗方式等进行调查分析,同时测定各患者的舒张压、收缩压、息肉直径等指标,根据分析结果筛选出术后迟发性出血的危险因素。 结果 3157例患者中有27例产生了术后迟发性出血症状,发生率为0.86%,迟发性出血多发生在息肉切除后的5~7 d后,平均为5.9±1.8 d,平均年龄为57.8±3.4岁,息肉平均的直径为32.1±3.7 mm。经单因素分析显示,与未出血患者相比,出血患者的高血压、年龄、息肉直径及形态、息肉生长位置有显著差异(P<0.05),即为此类症状的危险因素。将危险因素进行多因素回归分析,结果显示高血压、年龄、息肉生长位置为此类症状的独立危险因素(P<0.05)。 结论 高血压、年龄、息肉生长位置为术后迟发性出血的独立危险因素,临床应给予针对性预防措施。 Abstract:Objective To study the risk factors and prevention strategies of endoscopic resection of colorectal polyps delayed bleeding. Methods A total of 3157 patients who cured in my hospital endoscopic resection of colorectal polyps from July 2013 to June 2015 were chosed. Then we investigated the patient-related factors, the polyps related factors and some other relevant factors, at the same time.We measured each patient's diastolic blood pressure, systolic blood pressure and polyp diameter.Risk factors of delayed postoperative bleeding were screened and prevention measures summarized. Results Delayed bleeding occurred in 27/3157 patients (0.86%). Delayed bleeding was identified from 5 to 7 days after resection (mean, 5.9±1.8 days). The mean age was 57.8±3.4 years, and the average polyp size was 32.1±3.7 mm.Univariate analysis showed that, compared with the patient who was not bleeding, bleeding patients with high blood pressure, age, polyps diameter and shape were significant different (P<0.05). The multivariate regression analysis showed that high blood pressure, age, polyps position were independent risk factors (P<0.05). Conclusion High blood pressure, age, polyps position are independent risk factor for postoperative delayed bleeding, clinical should focus attention. -
Key words:
- polypectomy /
- delayed bleeding /
- risk factors /
- colonoscopy
-
表 1 内镜下大肠息肉切除术后迟发性出血的危险因素的单因素分析
因素 年龄(岁) 性别(男, %, n) 高血压(mmHg) 糖尿病(%,n) 息肉直径(%,n) 息肉形态(%,n) 息肉生长位置(%,n) 舒张压 收缩压 ≥25 mm <25 mm 有蒂 无蒂 直肠 升结肠 盲肠 横结肠 迟发性出血患者(n=27) 57.8±3.4* 70.1*(18) 95.63±3.21* 143.98±0.65* 11.1(3) 63.0*(17) 37.0*(10) 18.5*(5) 81.5*(22) 14.8*(4) 37*(10) 29.6*(8) 18.5*(5) 未发生迟发性出血患者(n=3130) 42.98±15.3 65.9(2062) 85.82±1.87 134.75±3.46 13.2(413) 7.6(238) 92.4(2892) 40.6(1270) 59.4(1860) 1.0(32) 6.8(213) 3.6(113) 9.3(291) t 25.213 5.972 30.855 32.741 1.832 38.964 37.429 40.683 45.795 50.934 49.721 57.997 47.825 P 0.043 0.832 0.04 0.041 0.102 0.028 0.03 0.017 0 0 0 0 0 *P<0.05vs未发生迟发性出血患者. 表 2 内镜下大肠息肉切除术后迟发性出血的危险因素的多因素分析
因素 年龄(岁) 高血压(mmHg) 息肉直径≥25 mm 息肉形态(有蒂) 息肉生长位置 直肠 升结肠 横结肠 回归系数 -1.947 1.583 0.342 0.434 0.163 -1.171 -1.125 WALD 6.827 10.896 0.333 0.371 4.045 4.772 3.066 P 0.011 0 0.123 0.372 0.035 0.026 0.043 95% CI 1.035(1.038-2.058) 1.490(1.110-2.304) 1.026(1.101-1.161) 7.582(2.948-20.172) 1.318(0.500-1.415) 1.812(1.129-2.757) 1.753(1.548-6.945) -
[1] Peto J. Cancer epidemiology in the last century and the next decade[J]. Nature, 2001, 411(6835): 390-5. doi: 10.1038/35077256 [2] Tsukuma H, Ajiki W. Descriptive epidemiology of colorectal cancer--international comparison[J]. Nippon Rinsho, 2003, 61(Suppl 7): 25-30. [3] 徐存美, 王秀莲, 粟 鹏. 内镜治疗大肠息肉临床疗效观察[J]. 中国医药指南, 2011, 9(16): 180-1. doi: 10.3969/j.issn.1671-8194.2011.16.133 [4] 赵昌学, 宋艳苹. 电视胸腔镜辅助下胸部小切口治疗食管平滑肌瘤[J]. 中国内镜杂志, 2010, 16(1): 91-2. http://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ201001035.htm [5] 任 旭, 徐晓红, 孙秀芝, 等. 经内镜切除消化道黏膜下肿瘤[J]. 中华消化内镜杂志, 2005, 22(1): 22-4. http://cdmd.cnki.com.cn/Article/CDMD-10422-1014307464.htm [6] Paspatis GA, Tribonias G, Konstantinidis K, et al. A prospective randomized comparison of cold vs hot snare polypectomy in the occurrence of postpolypectomy bleeding in small colonic polyps[J]. Colorectal Dis, 2011, 13(10): e345-8. doi: 10.1111/codi.2011.13.issue-10 [7] 黄丽韫, 毛 华, 金少琴, 等. 大肠息肉切除术后迟发性出血的危险因素分析[J]. 中国内镜杂志, 2012, 18(8): 809-12. http://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ201208010.htm [8] 任江南, 王国杰, 李啸峰, 等. 胃底息肉切除术后迟发性出血的危险因素及防治分析[J]. 胃肠病学和肝病学杂志, 2016, 25(8): 921-3. http://www.cnki.com.cn/Article/CJFDTOTAL-WCBX201608023.htm [9] 陈喜志, 王运红, 甘伟平. 结肠镜息肉切除术后迟发性出血的危险因素分析[J]. 广东医学, 2013, 34(24): 3781-4. http://www.cnki.com.cn/Article/CJFDTOTAL-GAYX201324037.htm [10] 陈晓武, 梁 彪, 王伟福, 等. 结肠镜息肉切除术后迟发性出血的危险因素分析[J]. 现代消化及介入诊疗, 2015, 34(4): 382-3. http://www.cnki.com.cn/Article/CJFDTOTAL-GAYX201324037.htm [11] 周 杰, 周 勇. 肠镜下大肠息肉切除的临床观察[J]. 现代预防医学, 2011, 38(4): 794-5. http://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201104093.htm [12] 余永明, 戴晓宇, 董明君, 等. 结肠镜与腹腔镜联合治疗大肠息肉16例临床分析[J]. 现代实用医学, 2011, 23(6): 685-6. http://www.cnki.com.cn/Article/CJFDTOTAL-NBYX201106045.htm [13] Yf T, Yang KF, Ren LK, et al. Clinical observation of 87 cases of electronic colonoscopy colon polyp ligationresection[J]. J Med Theor & Prac, 2010, 23(11): 1339-40. [14] Dobrowolski S, Dobosz M, Babicki A, et al. Blood supply of colorectal polyps correlates with risk of bleeding after colonoscopic polypectomy[J]. Gastrointest Endosc, 2006, 63(7): 1004-9. doi: 10.1016/j.gie.2005.11.063 [15] 曾安祥, 王胜炳, 朱德峰, 等. 大肠息肉结肠镜下摘除术后出血176例临床分析[J]. 现代诊断与治疗, 2015, 26(13): 3034-5. http://www.cnki.com.cn/Article/CJFDTOTAL-XDZD201513102.htm [16] 胡瑞红, 滕进波. 高危消化内镜干预对抗凝治疗患者的临床安全性研究[J]. 哈尔滨医药, 2014, 34(4): 259-61. http://www.cnki.com.cn/Article/CJFDTOTAL-XDXH201402004.htm [17] Kim DH, Lim SW. Analysis of delayed postpolypectomy bleeding in a colorectal clinic[J]. J Korean Soc Coloproctol, 2011, 27(1): 13-6. doi: 10.3393/jksc.2011.27.1.13
点击查看大图
表(2)
计量
- 文章访问数: 629
- HTML全文浏览量: 309
- PDF下载量: 6
- 被引次数: 0