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Volume 40 Issue 2
May  2018
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Article Navigation >  Journal of Molecular Imaging  > 2017  >  40(2): 148-151
Jianling HE, Zhimin JIANG, Liang CAI, Yule ZHANG, Cong LIU. Clinical value of DCE-MR in astrocytoma diagnosis and differential diagnosis[J]. Journal of Molecular Imaging, 2017, 40(2): 148-151. doi: 10.3969/j.issn.1674-4500.2017.02.07
Citation: Jianling HE, Zhimin JIANG, Liang CAI, Yule ZHANG, Cong LIU. Clinical value of DCE-MR in astrocytoma diagnosis and differential diagnosis[J]. Journal of Molecular Imaging, 2017, 40(2): 148-151. doi: 10.3969/j.issn.1674-4500.2017.02.07
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Clinical value of DCE-MR in astrocytoma diagnosis and differential diagnosis

doi: 10.3969/j.issn.1674-4500.2017.02.07
  • 1.

    Panyu Hospital of Chinese Medicine, Guangzhou 511400, China

  • 2.

    GE Healthcare, Guangzhou 510623, China

  • 3.

    Armed Police Guangdong Corps Hospital, Guangzhou 510507, China

  • 4.

    Guangzhou Women and Children’s Medical Center, Guangzhou 510623, China

  • 5.

    Guangzhou Panyu Central Hospital, Guangzhou 511400, China

  • Received Date: 2017-01-05
  • Publish Date: 2017-02-01
    Abstract
  • Objective To explore the clinical value of DCE-MR in astrocytoma diagnosis and differential diagnosis. Methods The magnetic resonance examination were performed in 60 cases of patients (Male 32, Female 28) with suspend of brain tumors by GE Signa HDxT 3.0T (GE medical system, Milwaukee) after the administration of Omniscan at the flow rate of 3 mL/s, 0.1 mmol/kg. The ROI was automatically selected by the OK software, three slides were measured. The measurement was trying to avoid blood vessels and artifacts. The Ktrans, Kep and Ve were calculated and the average value was taken. Results Tumor was found in 35 patients, 28 of them underwent surgery and biopsy, 14 astrocytomas, 3 meningiomas, 3 ependymomas, 4 metastases, 2 craniopharyngiomas and 2 acoustic neuroma. The pathological results showed that 3 of 14 astrocytomas were grade I, 4 were grade II, 4 were grade III and 3 were grade IV. Both values of high grade gliomas include grade Ⅲ and Ⅳ were significantly higher than that of low grade gliomas include gradeⅠ and Ⅱ (P<0.05). There was no statistically difference of the parameters of Ktrans and Ve values between grades Ⅰ with Ⅱ and grade Ⅲ with Ⅳ (P>0.05). Conclusion Quantitative DCE-MR parameters Ktrans, Kep and Ve value can be used to distinguish low grade and high grade astrocytoma, and evaluate the possibility of recurrence, plays an important role in discriminate different grade intracranial tumors in a preoperative noninvasive way.

     

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