Asthmatic bronchitis induced by adenovirus in children of different ages
-
摘要:
目的 通过分析儿童各年龄段喘息性支气管炎中腺病毒感染所致的比例特点,指导临床诊治。 方法 收集1132例于2014年1月~2016年7月在清远市人民医院儿科门急诊就诊或住院部治疗,临床并结合胸片结果诊断为喘息性支气管炎的儿童,依据年龄分为5组:<6个月组、≥6个月且<1岁组、≥1岁且<3岁组、≥3岁且<6岁组、≥6岁且<14岁组,分别根据呼吸道病毒检测结果,记录各组腺病毒阳性例数,计算腺病毒感染率并予统计分析。 结果 各组腺病毒感染率差异有统计学意义,以≥6岁且<14岁组腺病毒感染率最高(38.2%,χ2=35.216,P=0.000)。 结论 腺病毒感染所致儿童喘息性支气管炎在≥6岁且<14岁年龄段所占喘息性支气管炎比例最高,临床中应引起重视。 Abstract:Objective To analyze the characteristics of the proportion of the adenovirus infection in children with asthmatic bronchitis in different ages, and to guide the clinical diagnosis and treatment. Methods A total of 1132 cases from January 2014 to July 2016 in Qingyuan City People's Hospital pediatrics outpatient and emergency department or hospital treatment were chosed, with clinical and chest X-ray diagnosis for children of asthmatic bronchitis. According to ages,they were divided into 5 groups (<6 months, ≥6 months and <1 year old, ≥1 year old and <3 years old, ≥3 years of age and <6 years old, ≥6 years old and <14 years old), respectively according to the detection of respiratory viruses and they were recorded each adenovirus positive cases, calculate the positive rate of adenovirus and were given statistical analysis. Results Significant differences were found in the positive rate of each group of adenovirus. Adenovirus positive rate in group of ≥6 years old and <14 years old was the highest (x 2=35.216, P=0.000). Conclusion The highest proportion of the adenovirus infection in children with asthmatic bronchitis were in the ages of ≥6 years old and <14 years old group (elder age group), which in clinical diagnosis should be paid attention. -
Key words:
- adenovirus /
- children /
- asthmatic bronchitis /
- age
-
表 1 不同年龄组儿童喘息性支气管炎腺病毒感染率比较(n=1132,α=0.05)
分组 腺病毒感染(n,%) 有 无 合计 ≥6个月且<1岁 65(17.0%) 317(83.0%) 382(100.0%) 年龄≥1岁且<3岁 38(19.1%) 161(80.9%) 199(100.0%) ≥3岁且<6岁 40(22.5%) 138(77.5%) 178(100.0%) ≥6岁且<14岁 50(38.2%) 81(61.8%) 131(100.0%) χ2 35.216 P 0.000 合计 227(14.1%) 905(85.9%) 1132(100.0%) -
[1] Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-to 11-year-old children[J]. BMJ, 1995, 310(6989): 1225-9. [2] 杨曼琼, 黄 寒, 肖霓光. 小儿喘息性疾病喘息反复发作的病原学及危险因素分析[J]. 现代生物医学进展, 2013, 5(24): 4742-5. http://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201324037.htm [3] García-García ML, Calvo C, Falcón A, et al. Role of emerging respiratory viruses in children with severe acute wheezing[J]. Pediatr Pulmonol, 2010, 45(6): 585-91. [4] 王卫平, 毛 萌, 李廷玉, 等. 儿科学[M].8版. 北京: 人民卫生出版社, 2013: 268-9. [5] Maffey AF, Venialgo CM, Barrero PR, et al. New respiratory viruses in children 2 months to 3 years old with recurrent wheeze[J]. Arch Argent Pediatr, 2008, 106(4): 302-9. [6] Gern JE, Busse WW. The role of viral infections in the natural history of asthma[J]. J Allergy Clin Immunol, 2000, 106(2): 201-12. doi: 10.1067/mai.2000.108604 [7] Camara AA, Silva JM, Ferriani VP, et al. Risk factors for wheezing in a subtropical environment: role of respiratory viruses and allergen sensitization[J]. J Allergy Clin Immunol, 2004, 113(3): 551-7. doi: 10.1016/j.jaci.2003.11.027 [8] Chen HL, Chiou SS, Hsiao HP, et al. Respiratory adenoviral infections in children: a study of hospitalized cases in southern Taiwan in 2001--2002[J]. J Trop Pediatr, 2004, 50(5): 279-84. doi: 10.1093/tropej/50.5.279 [9] Rakes GP, Arruda E, Ingram JM, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care[J]. Am J Respir Crit Care Med, 1999, 159(3): 785-90. doi: 10.1164/ajrccm.159.3.9801052 [10] Jackson DJ, Evans MD, Gangnon RE, et al. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early Life[J]. Am J Respir Crit Care Med, 2012, 185(3): 281-5. doi: 10.1164/rccm.201104-0660OC [11] Heymann PW, Carper HT, Murphy DD, et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing[J]. J Allergy Clin Immunol, 2004, 114(2): 239-47. doi: 10.1016/j.jaci.2004.04.006 [12] Turunen R, Koistinen A, Vuorinen T, et al. The first wheezing episode: respiratory virus etiology, atopic characteristics, and illness severity[J]. Pediatr Allergy Immunol, 2014, 25(8): 796-803. doi: 10.1111/pai.12318 [13] 李成瑶, 付 娟, 陈 虹. 小儿喘息性疾病病因及流行病学分析[J]. 中国妇幼保健, 2012, 27(23): 3601-4. http://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201223024.htm [14] Lukkarinen M, Lukkarinen H, Lehtinen P, et al. Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up[J]. Pediatr Allergy Immunol, 2013, 24(3): 237-43. doi: 10.1111/pai.12046 [15] Jartti T, Kuusipalo H, Vuorinen T, et al. Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children[J]. Pediatr Allergy Immunol, 2010, 21(7): 1008-14. doi: 10.1111/pai.2010.21.issue-7 [16] Graham LM. Preschool wheeze prognosis: how do we predict outcome? [J]. Paediatr Respir Rev, 2006, 7(Suppl 1): S115-6. [17] Carroll KN, Gebretsadik T, Minton P, et al. Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections[J]. J Allergy Clin Immunol, 2012, 129(5): 1236-42. doi: 10.1016/j.jaci.2012.01.045 [18] Viegas M, Barrero PR, Maffey AF, et al. Respiratory viruses seasonality in children under five years of age in Buenos Aires, Argentina: a five-year analysis[J]. J Infect, 2004, 49(3): 222-8. doi: 10.1016/j.jinf.2003.10.006 [19] Videla C, Carballal G, Misirlian A, et al. Acute lower respiratory infections due to respiratory syncytial virus and adenovirus among hospitalized children from Argentina[J]. Clin Diagn Virol, 1998, 10(1): 17-23. doi: 10.1016/S0928-0197(98)00017-8 [20] 中华医学会儿科学分会呼吸学组, <中华儿科杂志>编辑委员会. 儿童社区获得性肺炎管理指南(2013年修订版) [J]. 中华儿科杂志, 2013, 51(10): 745-52. doi: 10.3760/cma.j.issn.0578-1310.2013.10.006
点击查看大图
表(1)
计量
- 文章访问数: 549
- HTML全文浏览量: 284
- PDF下载量: 0
- 被引次数: 0