Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy

CUI Hong; ZHU Xiaolan

doi:10.12122/j.issn.1674-4500.2022.02.24

Volume 45 Issue 2

Mar. 2022

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Article Navigation > Journal of Molecular Imaging > 2022 > 45(2): 279-283

CUI Hong, ZHU Xiaolan. Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy[J]. Journal of Molecular Imaging, 2022, 45(2): 279-283. doi: 10.12122/j.issn.1674-4500.2022.02.24

Citation:

CUI Hong, ZHU Xiaolan. Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy[J]. Journal of Molecular Imaging, 2022, 45(2): 279-283. doi: 10.12122/j.issn.1674-4500.2022.02.24

Citation:

CUI Hong, ZHU Xiaolan. Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy[J]. Journal of Molecular Imaging, 2022, 45(2): 279-283. doi: 10.12122/j.issn.1674-4500.2022.02.24

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Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy

doi: 10.12122/j.issn.1674-4500.2022.02.24

CUI Hong^,,
ZHU Xiaolan

Department of Ultrasound, Hai'an People's Hospital, Hai'an 226600, China

Received Date: 2021-09-30
Available Online: 2022-04-28
Publish Date: 2022-03-20

Abstract

Abstract

Objective To study the diagnostic of fetal cardiac malformations in early pregnancy by ultrasound detection of nuchal translucency (NT) thickening combined with Tei index and the factors influencing the diagnostic accuracy. Methods A total of 108 cases of pregnant women who underwent early pregnancy screening for congenital diseases in our hospital from January 2015 to February 2020 were selected as the research object. 101 cases of normal pregnant women who underwent pregnancy examination at the same time were selected as the control group. The differences in NT and Tei index between the two groups were compared to study the diagnostic efficacy of combined diagnosis of NT and Tei index for congenital heart disease and to analyse the factors influencing diagnostic accuracy. Results NT (t=16.780, P < 0.001) and Tei index (t=7.406, P < 0.001) in the observation group were significantly higher than those in the control group. The diagnostic specificity of combined diagnosis of NT and Tei index for congenital heart disease was significantly higher than that of individual tests, and the area under the curve of combined diagnosis of NT and Tei index was significantly higher than that of individual tests by ROC curve analysis. At the same time, through critical value analysis, for the diagnosis of congenital heart disease, the critical value of NT was 2.56 mm and the critical value of Tei index was 0.51. There were significant differences between the timing of screening, doctor's expertise and fetal position for accurate diagnosis and false-positive and false-negative patients (P < 0.05). The multifactorial analysis showed that the timing of screening, doctor's expertise and fetal position were all influential factors in the false positives and false negatives. Conclusion Ultrasonic detection of NT thickening combined with Tei index has positive implications for the diagnosis of fetal cardiac malformation in early pregnancy. In the diagnosis, the smaller timing of screening, the low expertise of the physician and lack of cooperation of the fetal position are all factors affecting the diagnostic accuracy.
- congenital heart disease,
- nuchal translucency,
- ultrasound,
- Tei index,
- joint detection

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Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy

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Diagnostic accuracy of nuchal translucency thickening combined with Tei index in fetal cardiac malformations in early pregnancy and impact factors of diagnostic accuracy

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