Research progress of photodynamic therapy for cervical intraepithelial neoplasia

LI Jiaosheng; GUO Yifan; YU Haotian

doi:10.12122/j.issn.1674-4500.2021.05.26

Volume 44 Issue 5

Sep. 2021

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LI Jiaosheng, GUO Yifan, YU Haotian. Research progress of photodynamic therapy for cervical intraepithelial neoplasia[J]. Journal of Molecular Imaging, 2021, 44(5): 863-867. doi: 10.12122/j.issn.1674-4500.2021.05.26

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LI Jiaosheng, GUO Yifan, YU Haotian. Research progress of photodynamic therapy for cervical intraepithelial neoplasia[J]. Journal of Molecular Imaging, 2021, 44(5): 863-867. doi: 10.12122/j.issn.1674-4500.2021.05.26

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Research progress of photodynamic therapy for cervical intraepithelial neoplasia

doi: 10.12122/j.issn.1674-4500.2021.05.26

LI Jiaosheng^{1, 2
,},
GUO Yifan^{2, 3
,
,},
YU Haotian^{1, 3
,
,}

1.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510168, China
2.
Department of Obstetrics and Gynecology, Hainan Hospital of PLA General Hospital, Sanya 572013, China
3.
Reproductive Medicine Center, Hainan Hospital of PLA General Hospital, Sanya 572013, China

Received Date: 2021-01-09
Publish Date: 2021-09-20

Abstract

Abstract

Cervical cancer has been the second leading cause of cancer- related deaths in women all over the world. The incidence rate of cervical cancer is higher in current years, and the main age of cervical cancer has been younger. Pap smears are more often used for the screening of cervical cancer, so more cervical intraepithelial neoplasia (CIN) have been found at earlier stage. Despite the high cure rate, conventional treatments of CIN may damage cervical stroma, thus can lead to reduce fertility such as infertility, abortion or preterm delivery. Therefore, a novel treatment for CIN that can leave fertility virtually intact, with similar cure rate, is urgently needed. Photodynamic therapy (PDT) is an effective therapy for CIN and it could maintain correct tissue structures and functions. PDT is applied for the cases with CIN especially for the younger patients who have the desire for future fertility. This review provides an overview of CIN and PDT. Furthermore, comparison of conventional treatments of CIN and PDT are comprehensively presented, especially investigating the therapeutic effects and clinical efficacy of these treatments in preserving fertility. Finally, we also discuss the limitations and future of PDT. This review aims to introduce the latest research progress of PDT for the treatment of cervical intraepithelial neoplasia, and would indicate new directions for our clinical work about CIN.
- photodynamic therapy,
- cervical intraepithelial neoplasia,
- fertility

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References(45)

References

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Research progress of photodynamic therapy for cervical intraepithelial neoplasia

doi: 10.12122/j.issn.1674-4500.2021.05.26

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