Risk factors of steatosis degree in patients with type 2 diabetes detected by transient elastography
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摘要:
目的 探讨使用瞬时弹性成像技术检测2型糖尿病的脂肪变程度危险因素。 方法 收集2015年1月~2016年5月在广西医科大学第三附属医院住院治疗的120例2型糖尿病患者临床资料，根据瞬时弹性成像技术检测的受控衰减参数（CAP）及饮酒情况分组：CAP<238 db/m组为正常组，CAP≥238 db/m为非酒精性脂肪肝组。比较两组年龄、性别、体质量、身高、体质量指数、病程、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、尿素氮、肌酐、尿酸、糖化血红蛋白、CAP、肝脏硬度等指标的差异，并分析CAP与各指标的关系。 结果 非酒精性脂肪肝组患者体质量高于正常组（P<0.05），多重线性回归分析得出2型糖尿病患者CAP与体质量具有相关性（r=0.726，P<0.05），得出回归方程为：Y=77.417+2.503X（Y为CAP，X为体质量）。 结论 体质量为2型糖尿病脂肪变程度的独立危险因素，脂肪变程度与体质量的变化呈线性相关关系。 Abstract:Objective To explore risk factors of steatosis degree in patients with type 2 diabetes detected by transient elastography. Methods Clinical data of 120 patients with type 2 diabetes in our hospital from January 2015 to May 2016 were collected. According to CAP and alcohol consumption, patients were divided into 2 groups: normal group of CAP<238 db/m, nonalcoholic fatty liver group (NAFLD group) of CAP≥238 db/m group. Age, gender, weight, height, BMI, duration, systolic blood pressure, diastolic blood pressure, total cholestero, triglycerides, high density lipoprotein, low density lipoprotein, blood urea nitrogen, creatinine, uric acid, glycated hemoglobin, controlled attenuation parameter (CAP) in two groups were compared. Results Weight of NAFLD group was higher than that of normal group (P<0.05). Multiple linear regression analysis showed, CAP and weight of T2DM patients were correlated (r=0.726). Regression equation obtained: Y=77.417+2.503X (Y for the CAP, X body weight). Conclusion Weight is a independent risk factors for steatosis degree in patiens with T2DM.Steatosis and body weight has a linear correlation. -
表 1 正常组和非酒精性脂肪肝组的一般资料比较（Mean±SD）
分组 例数 年龄（岁） 体质量（kg） 身高（cm） BMI 病程（年） 收缩压（mmHg） 舒张压（mmHg） 正常组 58 65.1±10.8 58.1±7.5 158.7±7.4 22.4±3.7 7.4±5.4 134.6±16.2 79.3±9.1 非酒精性脂肪肝组 62 63.9±11.9 67.8±14.1* 161.1±8.3 25.1±5.2 6.7±6.8 134.6±17.2 78.2±11.1 *P<0.05vs 正常组. 
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表 2 正常组和非酒精性脂肪肝组的生化指标比较（Mean±SD）
分组 胆固醇
（mmol/L）甘油三酯
（mmol/L）高密度脂蛋白
（mmol/L）低密度脂蛋白
（mmol/L）尿素氮
（mmol/L）肌酐
（μmol/L）尿酸
（mmol/L）糖化血红蛋白
（%）CAP
（db/m）肝脏
硬度正常组 4.9±1.5 1.3±0.7 1.3±0.3 3.1±1.3 5.6±2.5 80.2±31.2 332.3±127.6 9.6±3.1 211.3±18.9 65.11±10.8 非酒精性
脂肪肝组4.3±1.2 1.7±0.8 1.2±0.4 2.6±1.0 5.6±3.2 100.8±101.4 362.7±93.5 10.3±3.2 269.3±31.8* 63.9±11.9 *P<0.05vs 正常组.
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表 3 T2DM脂肪变程度相关危险因素的多重线性回归分析结果
变量 β SE β’ t P 常数 77.417 25.969 - 2.981 0.005 体质量 2.503 0.407 0.726 6.155 0.000
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