Relationship between expression levels of serum miR-409-3p after hyperthemic Intraperitoneal chemotherapy and the prognosis of gastric cancer
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摘要:
目的探讨高精度腹腔灌注化疗（HIPEC）治疗后血清miR-409-3P表达水平与胃癌预后的关系。 方法采用实时荧光定量聚合酶链反应检测高精度腹腔灌注化疗后血清miR-409-3p表达水平，并分析其胃癌预后的关系。 结果高精度腹腔灌注化疗后血清miR-409-3p低表达量组中位生存期低于高表达量组中位生存期，差异认为有统计学意义。 结论血清miR-409-3p可能成为评估预后的生物标志物。 -
关键词:
- miR-409-3p /
- 胃癌 /
- 预后
Abstract:ObjectiveTo investigate the relationship between expression levels of serum miR-409-3P after Hyperthemic Intraperitoneal Chemotherapy (HIPEC) and prognosis of gastric cancer. MethodsThe serum expression levels of miR-409-3p after HIPEC was examined using real-time reverse transcription polymerase chain reaction and analyze the relationship between levels and prognosis of gastric cancer. ResultsThe high expression group tended to have longer median survival time, compared with the low expression group, P=0.003. ConclusionsThe expression levels of serum miR-409-3P after HIPEC may become biomarkers of evaluate prognostic of gastric cancer. -
Key words:
- miR-409-3p /
- gastric cancer /
- prognostic
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表 1 血清miR-409-3p表达与临床病理特征关系
临床病理特征 miR-409-3p表达水平 P 低于平均值 高于平均值 性别 0.153 男 23 29 女 27 19 年龄(岁) 0.181 <50 13 14 50~60 22 27 >60 15 7 肿瘤最大径（cm） 0.800 <4.5 20 18 ≥4.5 30 30 分化程度 0.200 低 8 14 中 31 28 高 11 6 淋巴转移 0.034 无 10 19 有 40 29 远处转移 0.567 无 36 32 有 14 16 手术性质 0.568 姑息/未切除 15 17 根治性 35 31 TNM分期 0.567 Ⅲ期 34 30 Ⅳ期 16 18 
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表 2 单因素Logistic 回归分析血清miR-409-3p 表达与临床病理特征关系
临床病理因素 OR 95% CI P 性别 男 1.000 女 0.558 0.250~1.245 0.154 年龄（岁） <50 1.000 50~60 3.117 0.957~10.151 0.059 >60 2.232 0.775~6.428 0.137 肿瘤最大径（cm） <4.5 1.000 ≥4.5 0.280 0.692~3.567 0.280 分化程度 低 1.000 中 0.516 0.188~1.414 0.198 高 4.889 0.083~1.168 0.084 淋巴转移 无 1.000 有 2.621 1.063~6.463 0.036 远处转移 无 1.000 有 1.286 0.544~3.041 0.567 手术性质 姑息/未切除 1.000 根治性 0.782 0.335~1.821 0.568 TNM分期 Ⅲ期 1.000 Ⅳ期 0.258 0.554~2.934 0.568
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