Value of TPSA changing magnitude before and after antibiotic treatment in patients with ⅢA chronic prostatitis
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摘要:
目的探讨抗菌药物治疗前后ⅢA型慢性前列腺炎（CP）患者总前列腺特异抗原（TPSA）的浓度变化，及其在慢性前列腺炎发生、发展及疗效评价中的意义。 方法对68例不同类型ⅢA CP及38例非CP病例进行TPSA检测。对ⅢACP患者治疗前后均用电化学发光 方法检测直肠指检前的TPSA浓度，分析各组TPSA的表达水平及组间差异。 结果6例失随访，49例慢性前列腺炎治疗有效者，治疗后血清TPSA浓度较治疗前下降（P>0.05），而13例治疗无效者，血清TPSA浓度较治疗前无明显下降(P>0.05）。 结论ⅢA型慢性前列腺炎治疗前血清TPSA浓度升高，经抗菌药物治疗后随着炎症的消失，TPSA浓度可逐渐恢复正常，PSA浓度可作为ⅢA型慢性前列腺炎疗效评价的指标之一。 Abstract:Objective To investigate the changes of ⅢA chronic prostatitis (CP) in patients with total prostate specific antigen (TPSA) concentrations before and after antibiotic therapy，Which take the role of development and evaluation of the efficacy in chronic prostatitis. Methods A total of 68 patients suffered chronic prostatitis and 38 cases of non-CP patients, CP patients before and after treatment were detected by chemiluminescence electricity TPSA concentration before digital rectal examination and analyzing the expression levels, analysis the differences TPSA expression levels between the two groups. Results Six cases were lost follow-up. 49 cases of chronic prostatitis treatment was effective, TPSA serum concentrations after treatment than before treatment significantly decreased (P>0.05), and 13 cases of ineffective treatment,compared with before treatment decreased serum concentrations of TPSA obvious(P>0.05). Conclusions ⅢA Chronic prostatitis treatment before serum TPSA concentration after treatment with inflammation disappears, TPSA concentration can gradually return to normal, PSA concentrations can be used as an indicator of ⅢA chronic prostatitis evaluation. -
Key words:
- chronic prostatitis /
- total prostate specific antigen /
- antibiotic
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表 1 慢性前列腺炎患者治疗前后血清TPSA浓度（x±s）
组别 n 治疗前(ng/mL) 治疗后(ng/mL) P 有效组 49 2.38±0.69 1.74±0.54 <0.05 无效组 13 2.30±0.55 2.22±0.41 >0.05 
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