Application of three dimensional visualization technology for laparoscopic Resection of Follow-up study of gestational diabetes mellitus female ketone and inositol content and fetal malformation
-
摘要:
目的对孕早期孕妇酮体含量及肌醇代谢水平进行分析，了解妊娠期糖尿病（GDM）孕妇酮体与肌醇含量的变化与胎儿出现畸形的相关性，从而达到在孕早期对胎儿畸形进行预防的目的。 方法选取2010年1月~2013年6月间于我院确诊为GDM孕妇并在我院分娩产出畸形胎儿的患者19例，设为GDM组；另选取同期在我院进行常规检查并正常分娩的健康孕妇19例设为对照组。分别于两组研究对象怀孕3个月内时测定其体内酮体、肌醇和空腹血糖含量，并追踪统计畸形胎儿的类型，分析GDM孕妇酮体与肌醇含量的变化对胎儿出现畸形的影响。 结果两组研究对象在年龄、孕周、BMI等一般资料比较中差异不具有统计学意义（P>0.05）。经过对各项检测指标的分析发现，GDM组的孕妇酮体和空腹血糖含量显著高于对照组，而肌醇的含量水平则低于对照组。两组之间的比较差异具有统计学意义（P<0.05）。GDM组的孕妇娩出的畸形胎儿主要有无脑儿、脊柱裂、肾脏畸形及其他神经中枢缺损。 结论GDM孕妇酮体的含量和肌醇的代谢水平能够影响胎儿的正常发育，在孕早期胎儿是否存在畸形的预测中具有一定的价值，以此为指标可以在临床上对妊娠期糖尿病孕妇及时的进行补救或终止妊娠，减少畸形胎儿的发生率。 Abstract:Objective To understand GDM women ketones and inositol content changes and fetal deformity correlation to achieve in the first trimester of fetal malformations for the purpose of prevention. Methods Gestational diabetes (GDM) and pregnant women giving birth in hospital outputs 19 patients with fetal malformations collected from January 2010 to June 2013 in our hospital were set as GDM group. 19 cases with routine examination and normal healthy pregnan were set as control group. Study groups within 3 months of pregnancy when measured in vivo ketone, inositol and fasting blood glucose levels, and tracking statistics fetal malformation type analysis GDM women ketones and inositol content change effects on fetal deformity. Results Subjects in age, gestational age, BMI and other general information had no significant difference (P>0.05). After an analysis for the detection of indicators found, GDM group of pregnant women ketones and fasting plasma glucose levels were significantly higher, while the levels of inositol lower than the control group. The difference between the two groups was statistically significant (P<0.05). GDM group of pregnant women delivered a major fetal malformations or without brain child, spina bifida, kidney malformations and other central nervous system defects. Conclusions GDM women ketone levels and inositol metabolism can affect the normal development of the fetus in the first trimester of fetal malformations forecast whether there has a certain value, as a possible indicator for gestational diabetes in pregnant women clinically timely remedy or termination of pregnancy, to reduce the incidence of fetal malformations. -
Key words:
- gestational diabetes mellitus /
- ketones /
- inositol /
- fetal malformations
-
表 1 两组患者酮体、肌醇代谢物及空腹血糖含量比较（n=19）
组别 β-羟丁酸（mmol/L） IP-3（μg/L） FPG（mmol/L） GDM组 4.01±0.12 26.15±6.53 7.82±3.62 对照组 0.16±0.03 33.25±7.56 4.58±0.24 t 0.47 0.64 0.56 P ＜0.05 ＜0.05 ＜0.05 
下载: 导出CSV
-
[1] 余伏群. 妊娠期糖尿病筛查与影响原因分析[J]. 中国医药科学, 2013, 3(2): 196-7. [2] 卓苏铵. 妊娠合并糖尿病对母体与胎儿影响的临床研究[J]. 中国实用 医药, 2010, 5(16): 126-7. [3] 伊正辉, 王林杰, 常迎宾. 不同年龄大鼠胰腺组织中胰岛受体与磷脂酰 肌醇-3激酶表达水平的研究[J]. 中国医学创新, 2012, 9(14): 1-3. [4] 皮淑芳, 邸阜生, 王怀祯, 等. 胰岛素抵抗对血小板内磷脂酰肌醇3-激 酶活性影响的研究[J]. 天津医药, 2010, 38(7): 610-2. [5] 初永丽, 刘文娟, 崔青, 等. 磷脂酰肌醇-3激酶活性在妊娠期糖尿病患 者脂肪组织中的检测[J]. 中国妇产科临床杂志, 2010, 11(3): 210-2. [6] 何军锋, 严洁, 黄惠勇, 等. 针刺干预大鼠胰岛素抵抗及下丘脑胰岛素 受体后IRS1及其酪氨酸磷酸化的研究[J]. 中医药信息, 2013, 30(1): 70-2. [7] 詹俊, 岑坚兴, 陈浩英, 等. 快速血酮测定在糖尿病酮症酸中毒治疗中 的应用[J]. 中国医药指南, 2012, 10(28): 116-7. [8] 王硕石, 胡水旺, 钟梅. 妊娠期糖尿病合并妊娠期高血压疾病血清差 异蛋白的鉴定[J]. 南方医科大学学报, 2011, 31(7): 1224-7 [9] 韩文华. 胎儿神经管畸形21例超声诊断[J]. 山西医药杂志:下半月版, 2011, 40(18): 899. [10] Barreto SG, Carati CJ, Toouli J, et al. The islet-acinar axis of the pancreas: more than just insulin[J]. Am J Physiol Gastrointest Liver Physiol, 2010, 299(1): G10-22. [11] 张彬, 胡继芬, 游彩玲, 等. 妊娠期糖尿病与血清胎球蛋白A的关系 [J]. 中国临床医学, 2011, 18(6): 863-4. [12] Sopasakis VR, Liu P, Suzuki R, et al. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation[J]. Cell Metab, 2010, 11 (3): 220-30. [13] 黄帆. 超声诊断胎儿神经管畸形的临床价值[J]. 中国实用医药, 2011, 18(29): 125-8. [14] 王旭, 王进进, 徐奚如. 以磷脂酰肌醇-3激酶为靶点的2型糖尿病发 病机制研究进展[J]. 吉林大学学报:医学版, 2011, 37(6): 1161-4. [15] 周少锋, 黄泳华, 冯穗华, 等. 妊娠期糖尿病相关性危险因素分析(附 200例临床分析)[J]. 吉林医学, 2010, 31(18): 2828-9. -
点击查看大图
表(1)
计量
- 文章访问数: 1125
- HTML全文浏览量: 513
- PDF下载量: 7
- 被引次数: 0
