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摘要: 目的 子宫壁的力学特征包括子宫收缩与子宫壁抗张两个方面。子宫收缩导致子宫肌纤维形态、细胞外基质成分(ECM)以及子宫壁厚度的变化,难产或子宫瘢痕存在时,可能导致子宫壁破裂。研究表明,分娩史、难产史、剖宫产史均使子宫壁抗拉强度、刚度、应力松驰与蠕变等力学特征发生变化,其机制涉及子宫肌纤维与胶原纤维空间排列的变化、ECM中弹性成分与黏性分子(硫酸糖氨多糖等)量的改变,以及多种细胞膜离子通道的参与。
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