MOCA features of senile Leukoaraiosis cognitive impairment in Chaoshan area
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摘要:
目的分析潮汕地区60岁以上老年人群不同程度脑白质疏松（LA），应用蒙特利尔认知评估量表（MOCA）评估其认知障碍的特点。 方法选择潮汕地区60岁以上老年人不同程度LA患者187例，进行MOCA测评，分析LA程度与认知障碍特点的相关性。 结果MOCA总分与年龄、教育程度、LA级别、脑萎缩、高血压有相关性。重度LA患者认知功能障碍与无LA组比较差异有显著性意义。 结论潮汕地区老年人用MOCA筛查早期认知障碍的危险因素与年龄、教育程度、LA程度、脑萎缩、是否患高血压有关系，其中与年龄、LA程度、脑萎缩呈负相关，与教育程度呈正相关。脑白质疏松认知障碍的特点是Ⅲ~Ⅳ型LA，可以引起认知障碍，影响视空间与执行功能、计算、语言、延迟回忆与定向等方面功能。 -
关键词:
- 脑白质疏松 /
- 认知障碍 /
- 蒙特利尔认知评估量表
Abstract:Objective To analyze the characteristics of cognitive impairment by MOCA in Chaoshan area of elderly populationin different degree of Leukoaraiosis. Methods A total of 187 cases were collectted with population in different degree ofLeukoaraiosis over the age of 60 in Chaoshan area. The cognitive impairment were assessed by MOCA. Results The score ofMOCA was correlated with age, education level, LA level, brain atrophy and hypertension. There was a significant differencein the cognitive function between patients with severe LA and no LA group. Conclusion Age, education, LA, brain atrophyand hypertension are risk factors for early cognitive impairment assessment by MOCA. It is negatively correlated with age,LA, brain atrophy, and positively correlated with educational level.The characteristics of the cognitive impairment of LA istype Ⅲ to IV, which can lead to cognitive impairment, affect the visual space , executive function, calculation, language,delayed recall and orientation. -
Key words:
- leukoaraiosis /
- cognitive impairment /
- MOCA
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表 1 MOCA各项分数的相关性
年龄 教育 LA 脑萎缩 高血压 糖尿病 MOCA总分 r -0.270 0.458 -0.308 -0.339 -0.207 -0.053 P 0.000* 0.000* 0.000* 0.000* 0.004* 0.470 MOCA 1 r -0.203 0.631 -0.239 -0.215 -0.068 -0.145 视空间与执行功能 P 0.005* 0.000* 0.001* 0.003* 0.353 0.048 MOCA 2 命名 r 0.087 0.204 0.091 0.110 -0.190 -0.209 P 0.238 0.005* 0.215 0.135 0.009* 0.004* MOCA 4 计算 r -0.143 0.458 -0.209 -0.122 -0.128 -0.226 P 0.050 0.000* 0.004* 0.095 0.081 0.002* MOCA 5 语言 r -0.133 0.089 -0.211 -0.409 -0.153 -0.019 P 0.070 0.224 0.004* 0.000* 0.036* 0.795 MOCA 6 抽象 r -0.057 0.519 -0.077 -0.144 -0.019 0.009 P 0.442 0.000* 0.295 0.049* 0.799 0.179 MOCA 7 延迟回忆 r -0.218 0.104 -0.181 -0.271 -0.149 0.076 P 0.003* 0.156 0.013* 0.000* 0.042* 0.304 MOCA 8 定向 r -0.153 0.300 -0.286 -0.241 -0.241 -0.184 P 0.036* 0.000* 0.000* 0.001* 0.001* 0.012* *P<0.05. 
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表 2 程度不同LA患者与正常对照组的认知功能比较
检查项目 无LA（对照组）（n=58） 轻度LA（n=41） 中度LA（n=55） 重度LA（n=33） MOCA总分 21.66±4.76 21.11±4.91 16.79±5.94 Z 22.69±3.82 -1.03 -1.58 -5.90 P 0.602 0.99 0.000* MOCA 1 视空间与执行功能 2.95±1.43 2.38±1.45 1.85±1.56 Z 2.90±1.50 0.05 -0.51 -1.05 P 0.996 0.168 0.004* MOCA 2 命名 2.09±0.44 2.53±0.94 3.00±0.00 Z 2.79±0.41 0.11 -0.27 0.207 P 0.969 0.051 0.273 MOCA 4 计算 5.17±1.35 4.93±1.55 4.15±1.66 Z 5.28±0.99 -0.11 -0.35 -1.12 P 0.969 0.411 0.001* MOCA 5 语言 2.15±0.96 2.13±0.86 1.61±1.14 Z 2.33±0.82 -0.18 -0.20 -0.72 P 0.673 0.541 0.001* MOCA 6 抽象 1.07±0.93 0.91±0.91 0.61±0.90 Z 0.84±0.87 0.23 0.06 -0.24 P 0.477 0.968 0.495 MOCA 7 延迟回忆 1.44±1.43 1.96±1.49 0.73±1.26 Z 1.81±1.33 -0.37 0.15 -1.08 P 0.433 0.895 0.001* MOCA 8 定向 5.22±1.44 5.33±1.14 4.00±1.79 Z 5.53±1.03 -0.31 -0.21 -1.53 P 0.521 0.752 0.000* *P<0.05 vs 对照组.
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