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基质金属蛋白酶及其抑制剂在心血管疾病中的研究进展

吴伟东 刘丹 侯文进 易永盛 王跃军

吴伟东, 刘丹, 侯文进, 易永盛, 王跃军. 基质金属蛋白酶及其抑制剂在心血管疾病中的研究进展[J]. 分子影像学杂志, 2015, 38(4): 397-399. doi: 10.3969/j.issn.1674-4500.2015.04.28
引用本文: 吴伟东, 刘丹, 侯文进, 易永盛, 王跃军. 基质金属蛋白酶及其抑制剂在心血管疾病中的研究进展[J]. 分子影像学杂志, 2015, 38(4): 397-399. doi: 10.3969/j.issn.1674-4500.2015.04.28
Weidong WU, Dan LIU, Wenjin HOU, Yongsheng YI, Yuejun WANG. Progress of Matrix metalloproteinases and their Inhibitors in Cardiovascular disease[J]. Journal of Molecular Imaging, 2015, 38(4): 397-399. doi: 10.3969/j.issn.1674-4500.2015.04.28
Citation: Weidong WU, Dan LIU, Wenjin HOU, Yongsheng YI, Yuejun WANG. Progress of Matrix metalloproteinases and their Inhibitors in Cardiovascular disease[J]. Journal of Molecular Imaging, 2015, 38(4): 397-399. doi: 10.3969/j.issn.1674-4500.2015.04.28

基质金属蛋白酶及其抑制剂在心血管疾病中的研究进展

doi: 10.3969/j.issn.1674-4500.2015.04.28
详细信息
    作者简介:

    吴伟东,E-mail: william0406@163.com

Progress of Matrix metalloproteinases and their Inhibitors in Cardiovascular disease

  • 摘要: 基质金属蛋白酶(MMPs)及其抑制剂(TIMPs)在心肌细胞的损伤、心肌重构中有着重要的影响,因其发生发展过程复杂,主要机理目前还不完全明确,但众多研究表明,MMPs和TIMPs的动态平衡在心肌损伤中起着至关重要的作用,甚至可以为心肌梗死的早期检测和及早治疗而开发出一种新型的检测试剂,可以有效提高心血管疾病的早期诊断,对后续的治疗起到准确、科学的指导作用。下面就基质金属蛋白酶及其抑制剂在心血管疾病方面近几年的研究结果进行综述。

     

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    [15] Jeserich M, Konstantinides S, Pavlik GA, et al. Non-invasive imaging in the diagnosis of acute viral myocarditis[J]. Clin Res Cardiol, 2009, 98(12): 753-63. doi: 10.1007/s00392-009-0069-2
    [16] 蔡小芳, 麦根荣, 徐之良. 小儿扩张型心肌病与病毒性心肌炎的临床研究[J]. 中国当代儿科杂志, 2004, 6(4): 325-7. http://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ200404026.htm
    [17] Heymans S, Pauschinger M, De Palma AA, et al. Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis[J]. Circulation, 2006, 114(6): 565-73. doi: 10.1161/CIRCULATIONAHA.105.591032
    [18] Nelissen I, Martens E. Van den Steen PE, Proost P, Ronsse I Opdenakker G Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy[J]. Brain, 2003, 126(Pt 6): 1371-81.
    [19] Li J, Schwimmbeck PL, Tschope C, et al. Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction[J]. Cardiovasc Res, 2002, 56(2): 235-47. doi: 10.1016/S0008-6363(02)00546-1
    [20] Schnbeck U. Mach F,libby P.Generation of biologically active IL-1 beta by matrix metalloproteinases:a novel caspase-1 Independent pathway of IL-1 beta processing[J]. J Immunol, 1998, 161(7): 3340-6.
    [21] Meng XH, Wang Y, Zhuang JX, et al. Dynamic changes in myocardial matrix metalloproteinase activity in mice with viral myocarditis[J]. Chin Med J (Engl), 2004, 117(8): 1195-9.
    [22] Graham HK, Horn M, Trafford AW. Extracellular matrix profiles in the progression to heart failure[J]. Acta Physiologica, 2008, 194(1): 3-21. doi: 10.1111/aps.2008.194.issue-1
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    [24] Levick SP, Browerg L. Regulation ofmatrix metalloproteinase is at the heart of myocardial remodeling[J]. Am J Physiol Heart Circ Physiol, 2008, 295(4): H1375-6. doi: 10.1152/ajpheart.907.2008
    [25] Zavadzkas JA, Plyler RA, Bouges S, et al. Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causesmyocardial remodeling and dysfunction in aging mice[J]. Am J Physiol Heart Circ Physiol, 2008, 295(4): H1394-402. doi: 10.1152/ajpheart.00346.2008
    [26] 赵元, 周新民, 廖晓波, 等. 风湿性心脏病致心力衰竭患者心肌组织中基质金属蛋白酶-1, 9及其相关因子TIMP-4和EMMPRIN的表达及意义[J]. 中南大学学报: 医学版, 2009, 34(8): 790-5. http://www.cnki.com.cn/Article/CJFDTOTAL-HNYD200908021.htm
    [27] RouisM. Matrix metalloproteinases:a potential therapeutic target in atherosclerosis[J]. Curr Drug Targets Cardiovasc Haematol Disord, 2005, 5(9): 541-8.
    [28] KaiH, Ikeda H,Yasukawa H, et al. Peripheral blood levels of matrix metalloproteases-2 and-9 are elevated in patients with acute coronary syndromes[J].Am Coll Cardio, 1998, 32: 368-72. doi: 10.1016/S0735-1097(98)00250-2
    [29] Webb CS, Bonnema DD, Ahmed SH, et al. Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction:relation to left ventricular remodeling[J]. Circulation, 2006, 114(10): 1020-7. doi: 10.1161/CIRCULATIONAHA.105.600353
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出版历程
  • 收稿日期:  2015-06-01
  • 刊出日期:  2015-12-01

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