Clinical analysis of the treatment on heroin spongiform leukoencephalopathy by plasma exchange in 5 cases
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摘要:
目的分析海洛因海绵状白质脑病(HSLE)的临床特点和诊断治疗情况。 方法对5例HSLE患者的临床症状、影像学及血浆置换治疗进行分析。 结果3例临床症状改善,1例无变化,1例死亡。 结论HSLE患者均有海洛因吸食或静脉注射史,临床主要表现一系列神经系统症状,影像学显示受累部位多位于双侧小脑半球,脑干桥脑、中脑,丘脑、内囊后肢,额颞叶,枕顶叶,皮层下白质和脑室周围白质,胼胝体压部、血浆置换(PE)可能有效。 -
关键词:
- 海洛因海绵状白质脑病 /
- 血浆置换 /
- 临床
Abstract:ObjectiveTo analyze the clinical characteristics and diagnosis and treatments of heroin spongiform leukoencephalopathy (HSLE). Methodsthe clinical symptoms, imaging and plasma exchanges in 5 patients with HSLE were analyzed. Resultsthe clinical symptoms of 3 cases had improved, while 1 case had no change and 1 case died. ConclusionAll of HSLE patients had history of snorting or intravenous injection of heroin. The main clinical manifestations of them are a series of nervous system symptoms. Moreover imaging of them shows the involved sites were mostly located in the cerebellum hemispheres, brainstem, thalamus, the posterior limb of the internal capsule, white matter of subcortex and surrounding ventricle and the splenium of corpus callosum. Therefore, plasma exchange (PE) may be effective. -
Key words:
- heroin spongiform leukoencephalopathy /
- plasma exchange /
- Clinical
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