Clinical analysis of the treatment on heroin spongiform leukoencephalopathy by plasma exchange in 5 cases
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摘要:
目的分析海洛因海绵状白质脑病（HSLE）的临床特点和诊断治疗情况。 方法对5例HSLE患者的临床症状、影像学及血浆置换治疗进行分析。 结果3例临床症状改善，1例无变化，1例死亡。 结论HSLE患者均有海洛因吸食或静脉注射史，临床主要表现一系列神经系统症状，影像学显示受累部位多位于双侧小脑半球，脑干桥脑、中脑，丘脑、内囊后肢，额颞叶，枕顶叶，皮层下白质和脑室周围白质，胼胝体压部、血浆置换(PE)可能有效。 -
关键词:
- 海洛因海绵状白质脑病 /
- 血浆置换 /
- 临床
Abstract:ObjectiveTo analyze the clinical characteristics and diagnosis and treatments of heroin spongiform leukoencephalopathy (HSLE). Methodsthe clinical symptoms, imaging and plasma exchanges in 5 patients with HSLE were analyzed. Resultsthe clinical symptoms of 3 cases had improved, while 1 case had no change and 1 case died. ConclusionAll of HSLE patients had history of snorting or intravenous injection of heroin. The main clinical manifestations of them are a series of nervous system symptoms. Moreover imaging of them shows the involved sites were mostly located in the cerebellum hemispheres, brainstem, thalamus, the posterior limb of the internal capsule, white matter of subcortex and surrounding ventricle and the splenium of corpus callosum. Therefore, plasma exchange (PE) may be effective. -
Key words:
- heroin spongiform leukoencephalopathy /
- plasma exchange /
- Clinical
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[1] 陈俊浩, 李伟钦. 不同临床分期海洛因海绵状白质脑病患者的头颅 MRI特征临床分析[J]. 当代医学, 2012, 18(23): 100-1. http://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201223075.htm [2] 胡雪芹, 高冬梅, 周琳. 海洛因中毒性脑病的临床分析与影像学表现 [J]. 中国热带医学, 2010, 10(1): 100-1. http://www.cnki.com.cn/Article/CJFDTOTAL-RDYX201001061.htm [3] 尹恝, 潘速跃, 周亮, 等. 海洛因海绵状白质脑病病理分析[J]. 南方医科大学学报, 2007, 27(6): 881-3, 886. http://www.cnki.com.cn/Article/CJFDTOTAL-DYJD200706038.htm [4] 母艳蕾, 张华. 血浆置换在神经系统疾病中的应用[J]. 中国血液净化, 2012, 11(12): 642-5. http://www.cnki.com.cn/Article/CJFDTOTAL-ZGJH201212003.htm [5] 唐怡, 张凌, 杨莹莹, 等. 治疗性血浆置换临床应用新进展——解读 2010 ASFA新指南[J]. 中国实用内科杂志, 2012, 32(3): 229-31. http://www.cnki.com.cn/Article/CJFDTOTAL-SYNK201203024.htm [6] 蒋文贤, 朱珠, 潘鸿华, 等. 血浆置换联合丙种球蛋白在神经系统免疫性疾病中临床应用的综合探讨[J]. 中外医疗, 2014(29): 24-6. http://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201429013.htm [7] 殷文明, 张小宁. 吉兰-巴雷综合征的治疗研究进展[J]. 医学综述, 2014, 20(5): 875-7. http://www.cnki.com.cn/Article/CJFDTOTAL-YXZS201405035.htm -
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