Research progress of MicroRNAs in pathogenesis and treatment of lung cancer
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摘要: 肺癌是目前死亡率最高的的恶性肿瘤,且整体5年生存率偏低。尽管近年来放化疗技术和手术水平有了很大程度的提高,但肺癌的病死率基本保持不变,因此对肺癌的早期诊断和预防一直是近些年恶性肿瘤研究的热点。MicroRNA是一种非编码小分子RNA,可以调控50%以上的蛋白编码基因,且MicroRNA在血液和组织中都很稳定,因此它可以作为肺癌的标志物运用于肺癌的早期诊断。随着MicroRNA理论的研究进一步深入,将为肺癌的早期诊断和治疗带来了新的思路。Abstract: Lung cancer have the highest mortality rate in all malignant tumors currently. Also, its five-year survival rate is very low. Although the chemotherapy and operation level has been greatly improved, the mortality of lung cancer remains unchanged. It is very important that prevent, anticipate, and diagnose the cancer as soon as possible. MicroRNAs (miRNAs) are small non-coding RNA molecules capable of regulating expression of over 50% of protein-coding genes. The RNA molecules are stable in tissues and blood, so it can tend to be a biomarker in early diagnosis of lung cancer. Here, this is a review on the roles of miRNAs for possible ways to prevent lung cancer in clinical trials. With the improving understanding of the pathogenesis in lung cancer at the molecular, especially the study on MicroRNA theory, brings new hope for the early diagnosis and treatment of lung cancer.
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Key words:
- MicroRNAs /
- lung cancer /
- diagnosis
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[1] Siegel R, Ma JM, Zou ZH, et al. Cancer statistics [J]. JAMA, 2013, 310(9): 982. doi: 10.1001/jama.2013.5289 [2] Panda D, Dehury B, Sahu J, et al. Computational identification and characterization of conserved miRNAs and their target genes in garlic (Allium sativum L.) expressed sequence tags [J]. Gene, 2014, 537(2): 333-42. doi: 10.1016/j.gene.2014.01.010 [3] He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oneogene [J]. Nature, 435(7043): 745-6. doi: 10.1038/435745a [4] O'donnell KA, Wentzel EA, Zeller KI, et al. c-Myc-regulated microRNAs modulate E2F1 expression [J]. Nature, 2005, 435(743): 839-43. http://www.nature.com/nature/journal/v435/n7043/fig_tab/nature03677_F1.html [5] Hong LX, Lai MY, Chen M, et al. The miR-17-92 cluster of MicroRNAs confers tumorigenicity by inhibiting Oncogene Induced senescence [J]. Cancer Res, 2010, 70(21): 8547-57. doi: 10.1158/0008-5472.CAN-10-1938 [6] Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers [J]. Nature, 2005, 435(743): 834-8. http://academic.research.microsoft.com/Publication/6347684/microrna-expression-profiles-classify-human-cancers [7] Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia[J]. Proc Natl Acad Sci USA, 2002, 99(24): 15524-9. doi: 10.1073/pnas.242606799 [8] Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 MicroRNA family [J]. Cell, 2005, 120(5): 635-47. doi: 10.1016/j.cell.2005.01.014 [9] Huang P, Ye B, Zhao H. MicroRNA-181 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by targeting Bcl-2 [J]. Tumour Biol, 2014, 20: 15. http://www.docin.com/p-1640314203.html [10] Borkowski R, Du L, Pertsemlidis A. Genetic mutation of p53 and suppression of the miR-17-92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling [J]. Cancer Res, 2014, 17: 1329. http://paper.medlive.cn/literature/1242036 [11] Rao R, Nagarkatti PS, Nagarkatti M. Δ9 tetrahydrocannabinol attenuates staphylococcal enterotoxin b-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of t-regulatory cells[J]. Br J Pharmacol, 2014, 26: doi: 10.1111/bph.13026. [12] Chan YT, Yc L, Lin RJ, et al. Concordant and discordant regulation of target genes by miR-31 and its isoforms [J]. PLoS One, 2013, 8: e58169. doi: 10.1371/journal.pone.0058169 [13] Xia XM, Jin WY, Shi RZ, et al. Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer [J]. Oncol Lett, 2010, 1(6): 1045-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412505/ [14] 鲍美玲, 钱健, 殷长军. MiR-134通过靶向调节KRAS抑制786-0肾透明细胞癌细胞上皮间质转化过程[J].现代泌尿外科杂志, 2014, 12: 278. http://www.cqvip.com/QK/84104X/201406/50173103.html [15] Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 MicroRNA family [J]. Cell, 2005, 120(5): 635-47. doi: 10.1016/j.cell.2005.01.014 [16] Takamizawa J, Konishi H, Yanagisawa K, et al. Reduced expression of the let-7 MicroRNAs in human lung cancer in association with shortened postoperative survival[J]. Cancer Res, 2004, 64(11): 3753-6. doi: 10.1158/0008-5472.CAN-04-0637 [17] lncoronato M, Urso L, Portela A, et al. Epigenetic regulation of miR-212 expression in lung cancer[J]. PLoS One, 2011, 6: e27722. doi: 10.1371/journal.pone.0027722 [18] 田礼, 承文龙, 陈勇军.抑制Dicer基因对胆管癌细胞株TFK-1增殖, 迁移和侵袭的影响[J].中华肝胆外科杂志, 2014, 7: 48. http://d.wanfangdata.com.cn/Periodical/zhgdwk201407012 [19] 田小波, 张博, 陈洁平. microRNA相关基因DROSHA, DICER1, GEMIN4单核苷酸多态性与T细胞淋巴瘤患者预后的关系[J].中华血液学杂志, 2014, 5: 96. http://d.wanfangdata.com.cn/Periodical/zhxyx201405007 [20] Shen J, Todd NW, Zhang H, et al. Plasma microRNAs as potential biomarker for non-small lung Cancer[J]. Lab Invest, 2011, 91(8): 579-87. https://www.ncbi.nlm.nih.gov/pubmed/21116241 [21] Pellegrino L, Jacob J, Roca-Alonso L, et al. Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers[J]. Expert Rev Anticancer Ther, 2013, 13(1): 21-7. doi: 10.1586/era.12.150 [22] WilliamCSCHO, 丁燕, 南娟, 等. MiRNA作为肺癌分子诊断工具的前景与挑战[J].中国肺癌杂志, 2012, 2: 45-9. http://d.wanfangdata.com.cn/Periodical/zgfazz201202012 [23] 杨继学, 孙有树, 杨廷桐. miRNA与肺癌研究新进展[J].新乡医学院学报, 2014, 2: 118-9. http://www.cnki.com.cn/Article/CJFDTOTAL-XXYX201402021.htm [24] Guan P, Yin Z, Li X, et al. Meta-analysis of human lung Cancer microRNA expression profiling studies comparing cancer tissues with normal tissues [J]. J ExpClin Cancer Res, 2012, 31: 54. http://www.oalib.com/paper/256239 [25] Sun Y, Su B, Zhang P, et al. Expression of miR-150 and miR-3940-5p is reduced in non-small lung carcinoma and correlates with clinicopathological features [J]. Oncol Rep, 2013, 29 (5): 704-12. http://www.ncbi.nlm.nih.gov/pubmed/23228962 [26] Zhu W, Liu X, He J, et al. Overexpression of members of the microRNA-183 family is a risk factor for lung Cancer: a case control study [J]. BMC Cancer, 2011, 11(7): 393. http://www.oalib.com/paper/216319 [27] 南娟, 曹志成. MicroRNAs作为肺癌的治疗靶标[J].中国肺癌杂志, 2010, 12: 124-7. http://www.cnki.com.cn/Article/CJFDTOTAL-FAIZ201012025.htm [28] Yuan C, Wang X, Chen Y. Discovery of cashmere goat (Capra hircus) microRNAs in skin and hair follicles by Solexasequencing [J]. BMC Genomics, 2013, 28(14): 511. https://www.researchgate.net/publication/253332197_Discovery_of_cashmere_goat_Capra_hircus_microRNAs_in_skin_and_hair_follicles_by_Solexa_sequencing [29] Heegaard NH. ScheRer AL Welsh JA, yoneda M, bowman ED, harris CC [J]. Int J Cancer 2012, 130(6): 1378-86. doi: 10.1002/ijc.v130.6
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