Expression and clinical significances of survivin in benign and malignant lesions of breast
-
摘要:
目的 探讨乳腺良性、恶性病变中Survivin的表达及临床病理特征的关系。 方 法应用免疫组织化学SP法检测23例癌旁正常乳腺组织、28 例乳腺增生组织（其中20 例普通型增生，8 例非典型增生）、8 例导管内癌、98 例浸润性癌组织Survivin 的表达。 结果非典型增生上皮和导管内癌的Survivin水平高于正常乳腺腺上皮（P＜0.01）；浸润性导管癌组织中的Survivin表达率为49.0%高于正常乳腺腺上皮（P＜0.05）；与增生的乳腺组织和导管内癌组间差异无显著性。浸润性癌中的Survivin表达与分级、腋淋巴结转移、TNM分期有关，与病人的年龄、肿瘤大小、ER、PR无关。 结论Survivin在乳腺良恶性病变不同表达，提示其在乳腺癌发生、发展中起重要作用，可以为乳腺癌的诊断、治疗和预后提供依据。 Abstract:ObjectiveTo investigate the expression and clinical significances of survivin in benign and malignant lesions of breast. Methods The expression of survivin are observed using immunochemistry method in 23 cases of normal tissue beside malignant lesion, 28 cases of breast proliferative lesions (including 20 usual ductal hyperplasia, 8 atypical ductal hyperplasia), 8 cases of intraductal carcinoma, 98 cases of invasive ductal breast carcinoma. ResultsThe expression of survivin in atypical ductal hyperplasia and intraductal carcinoma was higher than that in normal tissue (P＜0.01); 49.0% of invasive ductal breast carcinoma expressed survivin, also higher than normal tissue (P＜0.05). There was no statistical significance of survivin expression between usual ductal hyperplasia and intraductal carcinoma. The expression of survivin in invasive ductal breast carcinoma was correlative to the grade, metastasis in lymph node and the TNM staging. It did not show any correlation between the age, size of tumor, expression of ER and PR. Conclusions The expression of survivin varies in different lesions, survivin may play a important role in tumorigendsis and progession of breast carcinoma and its overexpression indicates worse prognosis, which might be new application in the diagnosis, treatment and prognosis of breast cancer. -
Key words:
- Survivin /
- apoptotic protein /
- breast neoplasm
-
表 1 Survivin在正常及病变乳腺组织中的表达率
组别 n Survivin 高表达率(%) - + ++ +++ 正常 23 0 17 6 0 26.1 ADH 20 0 11 9 0 45.0 UDH 8 0 3 5 0 62.5** DCIS 8 0 3 5 0 62.5** 浸润性癌 98 7 43 4 4 49.0* 与正常组比较：*P＜0.05, **P＜0.01. 
下载: 导出CSV
表 2 Survivin与浸润性乳腺癌临床病理特征的关系
临床病理特征 n Survivin 高表达率（%） P - + ++-+++ 年龄（岁） ＞0.05 ≤35 9 1 5 3 33.3 ≤55 63 6 27 30 47.6 ＞55 26 0 11 15 57.7 肿瘤大小（cm） ＞0.05 ≤2 28 1 11 16 57.1 ≤5 49 6 18 25 51.0 ＞5 21 0 14 7 33.3 腋淋巴结转移 ＞0.05 0 36 2 8 26 72.2 1~3 40 4 23 13 50.0 >3 22 1 12 9 34.4 组织学分级 ＞0.05 Ⅰ 16 0 4 12 75.0 Ⅱ 50 2 23 25 50.0 Ⅲ 32 5 16 11 34.4 TNM分期 ＞0.05 Ⅰ 19 0 6 13 68.4 Ⅱ 58 7 23 28 48.3 Ⅲ 21 0 14 7 33.3
下载: 导出CSV
-
[1] Altieri DC. Survivin, versatile modulation of cell division and apoptosis in cancer[J]. Oncogene, 2003, 22(53): 8581-9. doi: 10.1038/sj.onc.1207113 [2] Andrade F, Roy S, Nicholson D, et al. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis[J]. Immunity, 1998, 8(4): 451-60. doi: 10.1016/S1074-7613(00)80550-6 [3] Ambrosini G, Adida C, Altieri DC. Anovelantic apoptosisgene, survivin expression in cancer and lymphoma[J]. Nat Med, 1997, 3(8): 917-21. doi: 10.1038/nm0897-917 [4] Verdecia MA, Huang H, Dutil E, et al. Structure of the human antiapoptotic protein survivin reveals a dimeric arrangement[J]. Nat Struct Biol, 2000, 7(7): 602-8. doi: 10.1038/76838 [5] Tanaka K, Iwamoto S, Gon G, et al. Expression of survivin and its relationship to loss of apoptosis in breast ccinomas[J]. Clin Cancer Res, 2000, 6(1): 127-34. http://cn.bing.com/academic/profile?id=934c48f58f5094963a5bceab7ac9b8fb&encoded=0&v=paper_preview&mkt=zh-cn [6] Sohn DM, Kim SY, Baek MJ, et al. Expression of survivin and clinical correlation in patients with breast cancer[J]. Biomed Pharmacother, 2006, 60(6): 289-92. doi: 10.1016/j.biopha.2006.06.008 [7] Son BH, Choi JS, Lee JH. Prognostic values of KAI1 and survivin expression in an infiltrating ductal carcinoma of the breast[J]. Pathology, 2005, 37(2): 131-6. doi: 10.1080/00313020500058144 -
点击查看大图
图(1) / 表(2)
计量
- 文章访问数: 640
- HTML全文浏览量: 227
- PDF下载量: 2
- 被引次数: 0
