Research status of high intensity focused ultrasound combined with nanoparticles in tumor treatment
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摘要: 在高强度聚焦超声消融肿瘤领域的研究中,理想的多模态多功能纳米诊疗剂不仅能够对感兴趣区域进行靶向治疗,还能特异性显影实现影像诊断的目的。二者联合应用可发挥协同作用,提高诊疗的精确性达到更好的治疗效果。本文就无机纳米颗粒、有机纳米颗粒、载有靶向基因的纳米颗粒、以化疗药物为核心的纳米颗粒在高强度聚焦超声消融肿瘤中的研究进展作一回顾。Abstract: In the field of high-intensity focused ultrasound ablation of tumors, the ideal multi-mode and multi-functional nano-therapeutic agent is not only able to target the region of interest, but also achieve specific imaging diagnosis. The combined application can exert synergistic effects and achieve better therapeutic effects. This paper presents a review of the progress of research on inorganic nanoparticles, organic nanoparticles, nanoparticles containing targeted genes, and chemotherapeutic drug-centered nanoparticles in high intensity focused ultrasound ablated tumors.
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Key words:
- high intensity focused ultrasound /
- targeted therapy /
- tumor ablation
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[1] Wang JJ, Wan L, Huang G, et al. Comparison of high-intensity focused ultrasound and microwave ablation for the treatment of small liver metastatic tumors[J]. J Int Med Res, 2023, 51(4): 1-12. [2] Liu L, Wang TF, Lei BY. High-intensity focused ultrasound (HIFU) ablation versus surgical interventions for the treatment of symptomatic uterine fibroids: a meta-analysis[J]. Eur Radiol, 2022, 32(2): 1195-204. doi: 10.1007/s00330-021-08156-6 [3] Zhang C, Liang MD, Xia TS, et al. Dosimetric analysis of ultrasound-guided high intensity focused ultrasound ablation for breast fibroadenomas: a retrospective study[J]. Int J Hyperthermia, 2022, 39(1): 743-50. doi: 10.1080/02656736.2022.2074151 [4] Bakavicius A, Marra G, Macek P, et al. Available evidence on HIFU for focal treatment of prostate cancer: a systematic review[J]. Int Braz J Urol, 2022, 48(2): 263-74. doi: 10.1590/s1677-5538.ibju.2021.0091 [5] Bongiovanni A, Foca F, Oboldi D, et al. 3-T magnetic resonance-guided high-intensity focused ultrasound (3 T-MR-HIFU) for the treatment of pain from bone metastases of solid tumors[J]. Support Care Cancer, 2022, 30(7): 5737-45. doi: 10.1007/s00520-022-06990-y [6] 王智彪, 李发琪, 冯若. 治疗超声原理与应用[M]. 南京: 南京大学出版社, 2008. [7] Abe S, Nagata H, Crosby EJ, et al. Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity[J]. J Immunother Cancer, 2022, 10(1): e003717. doi: 10.1136/jitc-2021-003717 [8] Glickstein B, Levron M, Shitrit S, et al. Nanodroplet-mediated low-energy mechanical ultrasound surgery[J]. Ultrasound Med Biol, 2022, 48(7): 1229-39. doi: 10.1016/j.ultrasmedbio.2022.02.018 [9] Alphandéry E. Ultrasound and nanomaterial: an efficient pair to fight cancer[J]. J Nanobiotechnology, 2022, 20(1): 139. 、 doi: 10.1186/s12951-022-01243-w [10] Zhao LY, Chao X, Yang BS, et al. Phase-shift perfluoropentane nanoemulsions enhance pulsed high-intensity focused ultrasound ablation in an isolated perfused liver system and their potential value for cancer therapy[J]. J Ultrasound Med, 2022, 41(1): 107-21. doi: 10.1002/jum.15686 [11] 孙廷宇, 王琦, 叶合敏, 等. 高强度聚焦超声联合脂质纳米氟碳液滴消融兔肝的实验研究[J]. 临床超声医学杂志, 2022, 24(3): 161-5. doi: 10.3969/j.issn.1008-6978.2022.03.001 [12] Ashar H, Ranjan A. Immunomodulation and targeted drug delivery with high intensity focused ultrasound (HIFU): principles and mechanisms[J]. Pharmacol Ther, 2023, 244: 108393. doi: 10.1016/j.pharmthera.2023.108393 [13] Peng Y, Dai Y, Yu GY, et al. Clinical evaluation of HIFU combined with GnRH-a and LNG-IUS for adenomyosis patients who failed to respond to drug therapies: two-year follow-up results[J]. Int J Hyperth, 2021, 38(1): 1271-5. doi: 10.1080/02656736.2021.1967467 [14] 伊万萍, 马德寿. 高强度聚焦超声通过TRIF介导的ERK通路增强乳腺癌的顺铂化疗敏感性[J]. 天津医药, 2022, 50(7): 698-706. [15] Do HD, Marie C, Bessoles S, et al. Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response[J]. Explor Med, 2022: 398-413. doi: 10.37349/etat.2022.00090 [16] Wang CM, Li ZF, Bai JW. Bubble-assisted HIFU ablation enabled by calcium peroxide[J]. J Mater Chem B, 2022, 10(23): 4442-51. doi: 10.1039/D2TB00587E [17] Bawiec CR, Rosnitskiy PB, Peek AT, et al. Inertial cavitation behaviors induced by nonlinear focused ultrasound pulses[J]. IEEE Trans Ultrason Ferroelectr Freq Contr, 2021, 68(9): 2884-95. doi: 10.1109/TUFFC.2021.3073347 [18] Wang R, Yao YJ, Gao YH, et al. CD133-targeted hybrid nanovesicles for fluorescent/ultrasonic imaging-guided HIFU pancreatic cancer therapy[J]. Int J Nanomed, 2023, 18: 2539-52. doi: 10.2147/IJN.S391382 [19] 寸江平, 赵卫, 范宏杰, 等. 动态血管模型在六氟化硫微泡联合高强度聚焦超声消融富血供子宫肌瘤中的增效作用[J]. 介入放射学杂志, 2020, 29(1): 51-7. doi: 10.3969/j.issn.1008-794X.2020.01.010 [20] 蒋红, 罗爽, 何敏, 等. HIFU联合超声微泡增效剂SonoVue治疗盆腔手术史子宫肌瘤患者研究[J]. 昆明医科大学学报, 2013, 34(9): 58-62, 88. [21] 鲁仁财, 赵卫, 易根发, 等. 微泡对比剂应用于高强度聚焦超声治疗子宫肌瘤疗效观察[J]. 介入放射学杂志, 2018, 27(1): 71-6. [22] Liu ST, Hou XQ, Zhu WJ, et al. Lipid perfluorohexane nanoemulsion hybrid for MRI-guided high-intensity focused ultrasound therapy of tumors[J]. Front Bioeng Biotechnol, 2022, 10: 846446. doi: 10.3389/fbioe.2022.846446 [23] Dai JY, Wu YF, Chen ZQ, et al. Sonosensitive phase-changeable nanoparticle mediated enhanced chemotherapy in prostate cancer by low-intensity focused ultrasound[J]. Int J Mol Sci, 2023, 24(1): 825. doi: 10.3390/ijms24010825 [24] 任春蓉, 张战峰, 陈春燕, 等. 载10-羟基喜树碱靶向相变纳米粒联合高强度聚焦超声治疗裸鼠肝癌移植瘤[J]. 临床超声医学杂志, 2021, 23(1): 4-8. [25] Tharkar P, Varanasi R, Wong WSF, et al. Nano-enhanced drug delivery and therapeutic ultrasound for cancer treatment and beyond[J]. Front Bioeng Biotechnol, 2019, 7: 324. doi: 10.3389/fbioe.2019.00324 [26] Han H, Lee H, Kim K, et al. Effect of high intensity focused ultrasound (HIFU) in conjunction with a nanomedicines-microbubble complex for enhanced drug delivery[J]. J Control Release, 2017, 266: 75-86. doi: 10.1016/j.jconrel.2017.09.022 [27] Yang QA, Zhou YH, Chen J, et al. Gene therapy for drug-resistant glioblastoma via lipid-polymer hybrid nanoparticles combined with focused ultrasound[J]. Int J Nanomed, 2021, 16: 185-99. doi: 10.2147/IJN.S286221 [28] Yang HY, Jiang FJ, Ji XJ, et al. Genetically engineered bacterial protein nanoparticles for targeted cancer therapy[J]. Int J Nanomed, 2021, 16: 105-17. doi: 10.2147/IJN.S292432 [29] Du Y, Lin L, Zhang Z, et al. Drug-loaded nanoparticles conjugated with genetically engineered bacteria for cancer therapy[J]. Biochem Biophys Res Commun, 2022, 606: 29-34. doi: 10.1016/j.bbrc.2022.03.049 [30] 蒋奕阳, 彭丽秀. HIFU联合药物治疗不同类型子宫腺肌病的临床研究[J]. 中国计划生育和妇产科, 2022, 14(8): 79-84. [31] 刘华, 周玲玲, 魏丹丹, 等. 红景天苷下调KRT17增加紫杉醇对卵巢癌细胞的化疗敏感性[J]. 天津中医药大学学报, 2022, 41(5): 625-9. [32] 何宇, 袁志鹏, 卢志斌, 等. LncRNA HOTAIR通过miR-130a-3p/ABCC5调控乳腺癌细胞紫杉醇耐药的分子机制研究[J]. 医学分子生物学杂志, 2023, 20(4): 316-23. [33] 牛建明, 赵晨茜, 张旭宇, 等. 注射用紫杉醇(白蛋白结合型)联合光动力疗法治疗晚期非小细胞肺癌致中心气道狭窄的临床效果[J]. 广西医学, 2023, 45(8): 916-22. [34] Li C, Lu Y, Cheng LL, et al. Combining mechanical high-intensity focused ultrasound ablation with chemotherapy for augmentation of anticancer immune responses[J]. Mol Pharm, 2021, 18(5): 2091-103.
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