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18F-FDG及18F-NaF正电子发射断层扫描在颈动脉粥样硬化斑块成像中的研究进展

高飞,  欧阳雪晖,  王慧杰

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文章导航 > 分子影像学杂志  > 2023 >  46(1): 181-187
高飞, 欧阳雪晖, 王慧杰. 18F-FDG及18F-NaF正电子发射断层扫描在颈动脉粥样硬化斑块成像中的研究进展[J]. 分子影像学杂志, 2023, 46(1): 181-187. doi: 10.12122/j.issn.1674-4500.2023.01.35
引用本文: 高飞, 欧阳雪晖, 王慧杰. 18F-FDG及18F-NaF正电子发射断层扫描在颈动脉粥样硬化斑块成像中的研究进展[J]. 分子影像学杂志, 2023, 46(1): 181-187. doi: 10.12122/j.issn.1674-4500.2023.01.35
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GAO Fei, OUYANG Xuehui, WANG Huijie. Progress of 18F-FDG and 18F-NaF positron emission tomography in carotid atherosclerotic plaque imaging[J]. Journal of Molecular Imaging, 2023, 46(1): 181-187. doi: 10.12122/j.issn.1674-4500.2023.01.35
Citation: GAO Fei, OUYANG Xuehui, WANG Huijie. Progress of 18F-FDG and 18F-NaF positron emission tomography in carotid atherosclerotic plaque imaging[J]. Journal of Molecular Imaging, 2023, 46(1): 181-187. doi: 10.12122/j.issn.1674-4500.2023.01.35
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18F-FDG及18F-NaF正电子发射断层扫描在颈动脉粥样硬化斑块成像中的研究进展

doi: 10.12122/j.issn.1674-4500.2023.01.35
  • 1.

    内蒙古医科大学内蒙古临床医学院，内蒙古 呼和浩特 010117

  • 2.

    内蒙古自治区人民医院医学影像科，内蒙古 呼和浩特 010017

基金项目: 

2022年度自治区卫生健康科技项目 202201031

详细信息
    作者简介:

    高飞，在读硕士研究生，E-mail: 18747073478@163.com

    通讯作者:

    欧阳雪晖，硕士，副主任医师，E-mail: 18748324400@163.com

Progress of 18F-FDG and 18F-NaF positron emission tomography in carotid atherosclerotic plaque imaging

  • 1.

    Inner Mongolia Clinical College, Inner Mongolia Medical University, Hohhot 010017, China

  • 2.

    Department of Medical Imaging, People's Hospital of Inner Mongolia Autonomous Region, Hohhot 010017, China

    摘要
  • 摘要: 卒中和脑内其他血栓栓塞事件通常是由于颈动脉粥样硬化所致，其中有炎症存在的动脉粥样硬化斑块更加脆弱，会增加临床症状出现的几率。动脉粥样硬化斑块的发生和发展涉及多种病理生理过程，包括炎症、细胞凋亡、坏死和钙化。正电子发射断层扫描（PET）不仅可以检测而且可以量化动脉粥样硬化形成的病理生理过程。在PET检查的基础上，18F-FDG在颈动脉粥样硬化中显示炎症过程有无可替代的作用，其是一种公认的评估动脉粥样硬化炎症的工具。同时，血管钙化过程在动脉粥样硬化斑块形成的早期阶段发挥重要作用，18F-NaF通过化学吸附沉积在羟基磷灰石上，据此可推断出动脉粥样硬化斑块内是否存在羟基磷灰石，进一步细化炎症过程中钙化的形成过程。本文基于18F-FDG和18F-NaF在PET/CT和PET/MRI上的不同的成像原理，阐述两种显像剂对与颈动脉斑块的最新进展情况。

     

    Abstract: Stroke and other thromboembolic events in the brain are usually due to carotid atherosclerosis, in which atherosclerotic plaques present with inflammation are more fragile and increase the chance of clinical symptoms. The development and progression of atherosclerotic plaques involves a variety of pathophysiological processes, including inflammation, apoptosis, necrosis, and calcification. PET can not only detect but also quantify the pathophysiological process of atherogenesis. On the basis of PET examination, 18F-FDG has an irreplaceable role in demonstrating the inflammatory process in carotid atherosclerosis, and it is a well-established tool for assessing atherosclerotic inflammation. At the same time, the process of vascular calcification plays an important role in the early stage of atherosclerotic plaque formation, and 18F-NaF is deposited on hydroxyapatite by chemisorption, based on which the presence of hydroxyapatite in atherosclerotic plaques can be deduced to further refine the formation process of calcification during inflammation. In this paper, based on the different imaging principles of 18F-FDG and 18F-NaF on PET/CT and PET/MRI, the latest progress of the two imaging agents on carotid plaques is described.

     

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  • 收稿日期:  2022-10-15
  • 网络出版日期:  2023-01-18
  • 刊出日期:  2023-01-20

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