多模态磁共振技术预测脑胶质瘤MGMT启动子甲基化状态的研究进展

靳向飞; 罗泽斌; 陈晓东

doi:10.12122/j.issn.1674-4500.2022.06.31

多模态磁共振技术预测脑胶质瘤MGMT启动子甲基化状态的研究进展

doi: 10.12122/j.issn.1674-4500.2022.06.31

靳向飞^1,,
罗泽斌^2, ,,
陈晓东^2, ,

1.
广东医科大学医学技术学院，广东东莞 523000
2.
广东医科大学附属医院放射科，广东湛江 524000

基金项目: 国家自然科学基金（82072507）；湛江市科技发展专项资金竞争性分配项目（2019A01026，2020A01024）；广东医科大学附属医院临床研究项目（LCYJ2020B010）；广东医科大学附属医院博士基金（BJ201521）

详细信息

作者简介:
靳向飞，在读硕士研究生，E-mail: JINxf99@163.com

通讯作者:
罗泽斌，主任医师，硕士生导师，E-mail: gdmcfsjd@qq.com

陈晓东，博士后，硕士生导师，E-mail: 45994381@qq.com

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出版历程
- 收稿日期: 2022-07-21
- 刊出日期: 2022-11-20

Progress of multimodality magnetic resonance techniques in predicting the MGMT promoter methylation status of glioma

JIN Xiangfei^1
,,
LUO Zebin^{2
, ,},
CHEN Xiaodong^{2
, ,}

1.
College of Medical Technology, Guangdong Medical University, Dongguan 523000, China
2.
Department of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China

Funds: Supported by National Natural Science Foundation of China (82072507)

摘要

摘要: 胶质瘤是最常见的原发性中枢神经系统恶性肿瘤。O⁶-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化是胶质瘤一个重要的分子特征，与烷化剂化疗敏感性、预后、风险分层、肿瘤复发等密切相关。当前仅使用手术标本通过基因检测分析来确定MGMT启动子甲基化状态，这一过程有局限性。MRI是目前应用最广泛的脑肿瘤非侵入性检查方法，近年来已有多种先进磁共振成像技术被用于术前无创性评估MGMT甲基化状态，这将有助于预测治疗反应和预后。本文就近几年化学交换饱和转移成像和酰胺质子转移成像、灌注加权成像（动态磁敏感对比增强成像、动态对比增强灌注成像、动脉自旋标记、基于流入的血管空间占位）、扩散成像（扩散张量成像、扩散峰度成像、体素内不相干运动、限制光谱成像）、磁敏感加权成像、波谱成像等磁共振成像技术预测MGMT甲基化状态的研究进展及MGMT甲基化临床意义进行综述，以期为患者个体化治疗方案的制定提供术前依据。
- 脑胶质瘤 /
- O⁶-甲基鸟嘌呤甲基转移酶 /
- 磁共振成像
Abstract: Gliomas are the most common primary central nervous system malignancy. O⁶-methylguanine-DNA methyltransferase (MGMT) promoter methylation is an important molecular feature of glioma, which is closely related to alkylating agent chemotherapy sensitivity, prognosis, risk stratification, and tumor recurrence. Currently, only surgical specimens are used for genetic testing analysis to determine the methylation status of MGMT promoters, but this process has limitations. MRI is currently the most widely used non-invasive examination method for brain tumors. In recent years, a number of advanced magnetic resonance imaging techniques have been used to assess MGMT methylation status non-invasively before surgery, which will help predict treatment response and prognosis. The paper reviewed the research progress of magnetic resonance imaging techniques to predict the methylation status of MGMT including chemical exchange saturation transfer imaging and amide proton transfer imaging, perfusion-weighted imaging (dynamic susceptibility contrast, dynamic contrast enhance, arterial spine labeling, and inflow-based vascular-space-occupancy), diffusion imaging (diffusion tensor imaging, diffusion kurtosis imaging, intravoxel incoherent motion, restriction spectrum imaging), susceptibility weighted imaging, magnetic resonance spectroscopy imaging and the clinical significance of MGMT methylation. In order to provide a preoperative basis for the formulation of individualized treatment plans for patients.
- glioma /
- O⁶-methylguanine-DNA methyltransferase /
- magnetic resonance imaging

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参考文献(62)

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多模态磁共振技术预测脑胶质瘤MGMT启动子甲基化状态的研究进展

doi: 10.12122/j.issn.1674-4500.2022.06.31

作者简介:
靳向飞，在读硕士研究生，E-mail: JINxf99@163.com

通讯作者:
罗泽斌，主任医师，硕士生导师，E-mail: gdmcfsjd@qq.com

陈晓东，博士后，硕士生导师，E-mail: 45994381@qq.com

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Progress of multimodality magnetic resonance techniques in predicting the MGMT promoter methylation status of glioma

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多模态磁共振技术预测脑胶质瘤MGMT启动子甲基化状态的研究进展

doi: 10.12122/j.issn.1674-4500.2022.06.31

作者简介: 靳向飞，在读硕士研究生，E-mail: JINxf99@163.com

通讯作者: 罗泽斌，主任医师，硕士生导师，E-mail: gdmcfsjd@qq.com 陈晓东，博士后，硕士生导师，E-mail: 45994381@qq.com

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Progress of multimodality magnetic resonance techniques in predicting the MGMT promoter methylation status of glioma

计量

出版历程

目录

作者简介:
靳向飞，在读硕士研究生，E-mail: JINxf99@163.com

通讯作者:
罗泽斌，主任医师，硕士生导师，E-mail: gdmcfsjd@qq.com

陈晓东，博士后，硕士生导师，E-mail: 45994381@qq.com