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Volume 42 Issue 4
Jan.  2020
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Article Navigation >  Journal of Molecular Imaging  > 2019  >  42(4): 461-464
Xuhong PENG, Dongliang YANG, Yuanlin LEI, Suping YANG, Yizhuang HUANG, Biyu LAI, Qingqian ZENG. Experimental study of lymph node imaging by MR contrast enhanced contrast agent[J]. Journal of Molecular Imaging, 2019, 42(4): 461-464. doi: 10.12122/j.issn.1674-4500.2019.04.09
Citation: Xuhong PENG, Dongliang YANG, Yuanlin LEI, Suping YANG, Yizhuang HUANG, Biyu LAI, Qingqian ZENG. Experimental study of lymph node imaging by MR contrast enhanced contrast agent[J]. Journal of Molecular Imaging, 2019, 42(4): 461-464. doi: 10.12122/j.issn.1674-4500.2019.04.09
shu

Experimental study of lymph node imaging by MR contrast enhanced contrast agent

doi: 10.12122/j.issn.1674-4500.2019.04.09
  • 1.

    Department of CT & MRI

  • 2.

    Department of Medicine, Qingyuan People's Hospital (The Sixth Affiliated Hospital of Guangzhou Medical University), Qingyuan 511518, China

  • Received Date: 2019-09-05
  • Publish Date: 2019-12-01
    Abstract
  • ObjectiveTo explore the differential diagnostic value of macromolecular positive lymphophilic contrast agent diaminoglycol ether DTPA amide copolymer gadolinium complex (Gd-poly-DTPA-EOEA) enhanced MR lymphography (MRL) in lymph node imaging of tumor metastasis and inflammatory hyperplasia.MethodsA total of 14 New Zealand white rabbits. Seven rabbits were injected with complete immune adjuvant at the hind limb to establish an inflammatory hyperplasia group model of popliteal fossa lymph node. The Other 7 were inoculated with VX2 tumor in the posterior limb muscle, suggesting the popliteal fossa lymph node metastasis model and the opposite normal popliteal fossa lymph node as the control. Two magnetic resonance lymphography were performed before and after inoculation. After 3D reconstruction, the signal to noise ratio (SNR) of the largest rabbit popliteal fossa nodes was measured. The SNR differences between normal control side, inflammatory hyperplasia side and metastatic side lymph nodes at each observation time point were compared with the results of pathological examination.ResultOne rabbit was not successfully inoculated with tumor, and other inoculations were good. All the model rabbits completed the secondary MR lymphography. On the MR lymphangiography image, there was no significant difference between the inflammatory side and the control side popliteal fossa nodes SNR at all scanning time points in the inflammatory hyperplasia group (P>0.05). In the tumor metastasis group, there were significant differences between the tumor side and the control side popliteal fossa lymph node SNR at each scanning time point (P<0.01). Further comparison was made between the inflammatory side and the tumor side popliteal fossa lymph nodes. The difference between the inflammatory side and the tumor side popliteal fossa lymph nodes SNR was significant at each scanning time point (P<0.01).ConclusionMR lymphography (MRL) based on macromolecular positive lymphophilic contrast medium (Gd-poly-DTPA-EOEA) enhancement is a sensitive method for differentiating benign from malignant lymph nodes.

     

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