Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease

Xiumei WANG; Changping LI

doi:10.12122/j.issn.1674-4500.2019.01.20

Volume 42 Issue 1

Jan. 2019

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Xiumei WANG, Changping LI. Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease[J]. Journal of Molecular Imaging, 2019, 42(1): 87-90. doi: 10.12122/j.issn.1674-4500.2019.01.20

Citation:

Xiumei WANG, Changping LI. Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease[J]. Journal of Molecular Imaging, 2019, 42(1): 87-90. doi: 10.12122/j.issn.1674-4500.2019.01.20

Xiumei WANG, Changping LI. Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease[J]. Journal of Molecular Imaging, 2019, 42(1): 87-90. doi: 10.12122/j.issn.1674-4500.2019.01.20

Citation:

Xiumei WANG, Changping LI. Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease[J]. Journal of Molecular Imaging, 2019, 42(1): 87-90. doi: 10.12122/j.issn.1674-4500.2019.01.20

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Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease

doi: 10.12122/j.issn.1674-4500.2019.01.20

Xiumei WANG,
Changping LI^,

Department of Gastroenterology, Affiliated Hospital of Xinan Medical University, Luzhou 646000, China

Received Date: 2018-04-03
Publish Date: 2019-01-01

Abstract

Abstract

MicroRNAs (miRNAs) are endogenous, non-coding small RNAs of approximately 19-25 nucleotides in length, which have a variety of regulatory roles in cells.Such as regulating the proliferation, apoptosis and differentiation of different cells.etc, mainly by targeting completely or incompletely the 3′-UTR region of mRNAs affects the translation and post-transcriptional regulation of targeted gene expression. Recent studies have found that microRNA-21 was involved in the pathogenesis of non-alcoholic fatty liver disease, which is related to its progression and prognosis. Comprehensive research found that the expression of microRNA-21 can be involved in the development of non-alcoholic fatty liver disease and its related complications through multiple targets, such as HMGCR, LRP6, PPAR-α. This article reviews the role and molecular mechanism of microRNA-21 in different stages of development of non-alcoholic fatty liver disease, and provides a basis for further research on the treatment of non-alcoholic fatty liver disease.
- non-alcoholic fatty liver disease,
- microRNA-21,
- microRNA-21 target,
- molecular mechanism

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References(37)

References

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Molecular mechanism of MicroRNA-21 in non-alcoholic fatty liver disease

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