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基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系

杨瑞芳 阴彦龙 杨敏清 宋丹

杨瑞芳, 阴彦龙, 杨敏清, 宋丹. 基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系[J]. 分子影像学杂志, 2017, 40(4): 482-485. doi: 10.3969/j.issn.1674-4500.2017.04.25
引用本文: 杨瑞芳, 阴彦龙, 杨敏清, 宋丹. 基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系[J]. 分子影像学杂志, 2017, 40(4): 482-485. doi: 10.3969/j.issn.1674-4500.2017.04.25
Ruifang YANG, Yanlong YIN, Minqing YANG, Dan SONG. Relationship between the serum matrix metalloproteinase levels,atherosclerosis and plaque rupture[J]. Journal of Molecular Imaging, 2017, 40(4): 482-485. doi: 10.3969/j.issn.1674-4500.2017.04.25
Citation: Ruifang YANG, Yanlong YIN, Minqing YANG, Dan SONG. Relationship between the serum matrix metalloproteinase levels,atherosclerosis and plaque rupture[J]. Journal of Molecular Imaging, 2017, 40(4): 482-485. doi: 10.3969/j.issn.1674-4500.2017.04.25

基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系

doi: 10.3969/j.issn.1674-4500.2017.04.25
详细信息
    作者简介:

    杨瑞芳,硕士研究生,E-mail: 1083990814@qq.com

    通讯作者:

    阴彦龙,硕士,主任医师,E-mail: 150545789622126.com

Relationship between the serum matrix metalloproteinase levels,atherosclerosis and plaque rupture

  • 摘要: 动脉粥样硬化是冠心病、脑梗死、外周血管病的主要原因,严重威胁到人类的健康和生命。尤其是冠心病,动脉粥样硬化是其最重要因素之一,主要是由于各种原因引起血管内皮细胞损伤,破坏屏障功能,血液中各种巨噬细胞广泛侵入内膜,形成以脂质为主的粥样斑块,引起血管重构,进一步发展,可引起斑块破裂。基质金属蛋白酶是一组几乎能降解血管外细胞基质所有成分的一组酶,在动脉硬化斑块的区域可过度表达,降解基质,引起斑块破裂、出血,形成继发血栓,引发急性冠状动脉综合征。本文着重从基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系作一综述。

     

  • [1] Bar-Or A, Nuttall RK, Duddy M, et al. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis[J]. Brain, 2003, 126(Pt 12): 2738-49.
    [2] Murphy G, Stanton H, Cowell S, et al. Mechanisms for pro matrix metalloproteinase activation[J]. APMIS, 1999, 107(1): 38-44.
    [3] Metalloproteinases ML, their inhabitors in matrix remodelling[J]. Trends Genetics, 1990, 6(11): 121-5.
    [4] Lambert E, Dassé E, Haye B, et al. TIMPs as multifacial proteins[J]. Crit Rev Oncol Hematol, 2004, 49(3): 187-98. doi: 10.1016/j.critrevonc.2003.09.008
    [5] Vesey DA, Cheung CW, Kruger WA, et al. Thrombin stimulates proinflammatory and proliferative responses in primary cultures of human proximal tubule cells[J]. Kidney Int, 2005, 67(4): 1315-29. doi: 10.1111/j.1523-1755.2005.00209.x
    [6] Nagase H. Activation mechanisms of matrix metalloproteinases[J]. Biol Chem, 1997, 378(3/4): 151-60.
    [7] Sarén P, Welgus HG, Kovanen PT. TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages[J]. J Immunol, 1996, 157(9): 4159-65.
    [8] Galis ZS, Muszynski M, Sukhova GK, et al. Cy tokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extra-celluar matrix digestion[J]. Circ Res, 1994, 75(12): 181-9.
    [9] 陈华江, 王杰军. 基质金属蛋白酶的结构及其调节机制[J]. 国外医学: 肿瘤学分册, 2001, 28(1): 20-3. http://d.wanfangdata.com.cn/Periodical/gwyx-zlxfc200101007
    [10] Schönbeck U, Mach F, Sukhova GK, et al. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture[J]. Circ Res, 1997, 81(3): 448-54. doi: 10.1161/01.RES.81.3.448
    [11] Mach F, Schönbeck U, Bonnefoy JY, et al. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor[J]. Circulation, 1997, 96(2): 396-9. doi: 10.1161/01.CIR.96.2.396
    [12] Schönbeck U, Mach F, Sukhova GK, et al. Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo[J]. J Exp Med, 1999, 189(5): 843-53. doi: 10.1084/jem.189.5.843
    [13] Kleiner DE, Stetler-Stevenson WG. Matrix metalloproteinases and metastasis[J]. Cancer Chemother Pharmacol, 1999, 43(1): S42-51.
    [14] Strongin AY, Collier I, Bannikov G, et al. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease[J]. J Biol Chem, 1995, 270(10): 5331-8. doi: 10.1074/jbc.270.10.5331
    [15] 陈线茹, 豆志伟. 基质金属蛋白酶与动脉粥样硬化病变的关系[J]. 心血管病学进展, 2012, 33(3): 314-7. http://d.wanfangdata.com.cn/Periodical/xxgbxjz201203010
    [16] Dickhout LR. Functional analysis of arteries from young spontaneously hypertensiverats[J]. Hypertension, 1997, 29(3): 781-9. doi: 10.1161/01.HYP.29.3.781
    [17] 于 滢, 杨向红. 基质金属蛋白酶与动脉粥样硬化及斑块破裂的关系[J]. 中国动脉硬化杂志, 2003, 11(6): 592-5. http://d.wanfangdata.com.cn/Periodical/zgdmyhzz200306030
    [18] Galis ZS, Muszynski M, Sukhova GK, et al. Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions[J]. Ann N Y Acad Sci, 1995, 748(2): 501-7.
    [19] Galis ZS, Sukhova GK, Kranzhöfer R, et al. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases[J]. Proc Natl Acad Sci USA, 1995, 92(2): 402-6. doi: 10.1073/pnas.92.2.402
    [20] Liu YN, Pan SL, Peng CY, et al. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9[J]. J Pharmacol Exp Ther, 2006, 316(1): 35-41.
    [21] 范成辉, 庄少伟. 急性冠状动脉综合征相关易损斑块的研究现状[J]. 上海医学, 2016, 39(3): 184-6.
    [22] Rouis M. Matrix metalloproteinases: a potential therapeutic target in atherosclerosis[J]. Curr Drug Targets Cardiovasc Haematol Disord, 2005, 5(6): 541-8. doi: 10.2174/156800605774961979
    [23] Galis ZS, Sukhova GK, Lark MW, et al. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques[J]. J Clin Invest, 1994, 94(6): 2493-503. doi: 10.1172/JCI117619
    [24] Nikkari ST, O'brien KD, Ferguson M, et al. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis[J]. Circulation, 1995, 92(6): 1393-8. doi: 10.1161/01.CIR.92.6.1393
    [25] Rekhter MD, Zhang K, Narayanan AS, et al. Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions[J]. Am J Pathol, 1993, 143(6): 1634-48.
    [26] Sukhova GK, Schönbeck U, Rabkin E, et al. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques[J]. Circulation, 1999, 99(19): 2503-9. doi: 10.1161/01.CIR.99.19.2503
    [27] Herman MP, Sukhova GK, Libby P, et al. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling[J]. Circulation, 2001, 104(16): 1899-904. doi: 10.1161/hc4101.097419
    [28] Ibanez B, Navarro F, Cordoba M, et al. Tako-tsubo transient left ventricular apical ballooning: is intravascular ultrasound the key to resolve the enigma? [J]. Heart, 2005, 91(1): 102-4. doi: 10.1136/hrt.2004.035709
    [29] Merli E, Sutcliffe S, Gori M, et al. Tako-Tsubo cardiomyopathy: new insights into the possible underlying pathophysiology[J]. Eur J Echocardiogr, 2006, 7(1): 53-61. doi: 10.1016/j.euje.2005.08.003
    [30] Cocco G, Chu D. Stress-induced cardiomyopathy: A review[J]. Eur J Intern Med, 2007, 18(5): 369-79. doi: 10.1016/j.ejim.2007.02.021
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出版历程
  • 收稿日期:  2017-06-28
  • 网络出版日期:  2017-10-01
  • 刊出日期:  2017-10-01

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