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微小核糖核酸与男性不育的相关性

成玥美,  刘海燕,  赵小东,  岳丰,  王一青,  刘琳

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文章导航 > 分子影像学杂志  > 2017 >  40(4): 469-473
成玥美, 刘海燕, 赵小东, 岳丰, 王一青, 刘琳. 微小核糖核酸与男性不育的相关性[J]. 分子影像学杂志, 2017, 40(4): 469-473. doi: 10.3969/j.issn.1674-4500.2017.04.22
引用本文: 成玥美, 刘海燕, 赵小东, 岳丰, 王一青, 刘琳. 微小核糖核酸与男性不育的相关性[J]. 分子影像学杂志, 2017, 40(4): 469-473. doi: 10.3969/j.issn.1674-4500.2017.04.22
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Yuemei CHENG, Haiyan LIU, Xiaodong ZHAO, Feng YUE, Yiqing WANG, Lin LIU. Correlation of MicroRNA with asthenozoospermia[J]. Journal of Molecular Imaging, 2017, 40(4): 469-473. doi: 10.3969/j.issn.1674-4500.2017.04.22
Citation: Yuemei CHENG, Haiyan LIU, Xiaodong ZHAO, Feng YUE, Yiqing WANG, Lin LIU. Correlation of MicroRNA with asthenozoospermia[J]. Journal of Molecular Imaging, 2017, 40(4): 469-473. doi: 10.3969/j.issn.1674-4500.2017.04.22
shu

微小核糖核酸与男性不育的相关性

doi: 10.3969/j.issn.1674-4500.2017.04.22
详细信息
    作者简介:

    成玥美，E-mail: 243652850@qq.com

    通讯作者:

    刘 琳，博士，E-mail: smilez2013@163.com

Correlation of MicroRNA with asthenozoospermia

  • The Second Clinical Medical School of Lanzhou University, Lanzhou 730000, China

  • 2.

    The First Hospital of Lanzhou University, Reproductive Medicine Specialist Hospital, Key Laboratory of Reproductive Medicine and Embryo in Gansu, Lanzhou 730000, China

    摘要
  • 摘要: 近年来，许多研究证明微小核糖核酸（miRNA）作用于精子的发生发展，与男性生育有着一定的联系。miR-122的靶向调控对精子的发育产生影响，hsa-miR-629-3p、hsa-miR-335-5p、hsa-miR-885-5和hsa-miR-152-3p与精子活力及密度密切相关。FMRP- miR-383调控通路的失调导致男性不育。miR-27、miR-34c-3p分别抑制了CRISP2和PLCXD3蛋白的表达，从而影响精子的形态和活力。此外，miR34b/449基因座的缺失有可能导致少弱畸精子症的发生。本文将从miRNA在精子生成中的作用、与男性不育的关系以及其在弱精症患者中的研究等几个方面进行综述。

     

    Abstract: In recent years, many studies have demonstrated that miRNA could act on the development of spermatozoa. It had a certain relationship with male fertility. The targeted regulation of miR-122 had an effect on the development of sperm. The hsa-miR-629-3p, hsa-miR-335-5p, hsa-miR-885-5 and hsa-miR-152-3p were closely related to sperm motility and density. The disorder of the FMRP-miR-383 regulatory pathway lead to male infertility. The miR-27、miR-34c-3p inhibited the expression of CRISP2 and PLCXD3 proteins respectively, which affected the morphology and vitality of sperm. In addition, the deletion of miR34b/449 locus could lead to the occurrence of asthenospermia. This article reviews the effect of miRNA on spermatogenesis, the relationship between miRNA and male infertility and miRNA in patients with weak spermia.

     

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    • 参考文献(46)
  • [1] 潘 怡. 微小核糖核酸在疾病发生发展以及药物疗效预测中的作用机制[D]. 南京: 南京大学,2016.
    [2] 冉茂良, 陈 斌, 尹 杰, 等. 睾丸发育和精子生成相关miRNA研究进展[J]. 遗传, 2014, 36(7): 646-54. http://d.wanfangdata.com.cn/Periodical/yc201407004
    [3] Lehrbach NJ, Miska EA. Regulation of pre-miRNA processing[J]. Adv Exp Med Biol, 2010, 700(4): 67-75.
    [4] Ran M, Chen B, Yin J, et al. Advances in miRNA research related to testis development and spermatogenesis[J]. Hereditas, 2014, 36(7): 646-54.
    [5] Kotaja N. MicroRNAs and spermatogenesis[J]. Fertil Steril, 2014, 101(6): 1552-62. doi: 10.1016/j.fertnstert.2014.04.025
    [6] 杨 菁, 张 燕. 不孕症研究概况[J]. 国外医学:妇幼保健分册, 2005, 16(4): 232-5. http://d.wanfangdata.com.cn/Periodical/gwyx-fybj200504016
    [7] 焦瑞宝,唐吉斌,姚余有.弱精症相关基因,蛋白及酶学研究进展[J].实验与检验医学, 2016, 34(4): 473-6. http://d.wanfangdata.com.cn/Periodical/jiangxyxjy201604019
    [8] Yang Q, Hua J, Wang L, et al. MicroRNA and piRNA profiles in normal human testis detected by next Generation sequencing[J]. PLoS One, 2013, 8(6): e66809-11. doi: 10.1371/journal.pone.0066809
    [9] Hu L, Wu C, Guo C, et al. Identification of microRNAs predominately derived from testis and epididymis in human seminal plasma[J]. Clin Biochem, 2014, 47(10/11): 967-72.
    [10] Luo L, Ye L, Liu G, et al. Microarray-based approach identifies differentially expressed microRNAs in porcine sexually immature and mature testes[J]. PLoS One, 2010, 5(8): e11744-7. doi: 10.1371/journal.pone.0011744
    [11] 罗萌萌, 郝丽丽, 胡 芬, 等. 小鼠精子发生早期microRNA的表达谱和调控模-miRNA在小鼠精子发生中的作用[J]. 中国科学:生命科学, 2014, 44(11): 1142-51.
    [12] 于 洋, 李 燕, 梁雨蒙, 等. 环境污染地区成年男性精子microRNA表达谱的建立[J]. 阜阳师范学院学报:自然科学版, 2011, 28(3): 54-61. http://d.wanfangdata.com.cn/Periodical/fysfxyxb-zrkxb201103016
    [13] Lorenz DA, Song JM, Garner AL. High-throughput platform assay technology for the discovery of pre-microrna-selective small molecule probes[J]. Bioconjug Chem, 2015, 26(1): 19-23. doi: 10.1021/bc500544v
    [14] Yuan S, Schuster A, Tang C, et al. Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development[J]. Development, 2016, 143(4): 635-47. doi: 10.1242/dev.131755
    [15] Liu T, Huang Y, Liu J, et al. Micro RNA-122 influences the development of sperm abnormalities from human induced pluripotent stemcells by regulating TNP2 expression[J].Stem Cells Developm, 2013, 22(12): 1839-50. doi: 10.1089/scd.2012.0653
    [16] Salas HA, Blanco J, Vidal F, et al. Spermatozoa from patients with seminal alterations exhibit a differential micro-ribonucleic acid profile[J]. Fertil Steril, 2015, 104(3): 591-601. doi: 10.1016/j.fertnstert.2015.06.015
    [17] Salas HA, Blanco J, Vidal F, et al. Spermatozoa from normo-zoospermic fertile and infertile individuals convey a distinct miRNA cargo[J]. Andrology, 2016, 4(6): 1028-36. doi: 10.1111/andr.12276
    [18] Lü M, Tian H, Cao YX, et al. Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation[J]. Cell Death Dis, 2015, 6(11): e1960-6. doi: 10.1038/cddis.2015.267
    [19] 查 醒, 贺小进, 曹云霞. MicroRNA与男性不育研究新进展[J]. 生殖与避孕, 2014, 34(11): 925-9. doi: 10.7669/j.issn.0253-357X.2014.11.0925
    [20] 田 卉. miRNA和遗传因素在男性不育发生中的功能研究[D]. 合肥: 中国科学技术大学, 2014.
    [21] 韩晓冬, 周 源. 微小核糖核酸与雄性生殖[J]. 中华男科学杂志, 2015, 21(11): 963-6. http://d.wanfangdata.com.cn/Periodical/zhnkx201511001
    [22] 朱媛媛, 王 成. 精浆微小核糖核酸研究进展[J]. 中华男科学杂志, 2013, 19(11): 1039-42. http://d.wanfangdata.com.cn/Periodical/zhnkx201311017
    [23] 王 燕, 郭文龙, 耿德海, 等. 精子发生过程中调控性非编RNAs的功能[J]. 医学研究与教育, 2014, 31(6): 95-9.
    [24] 吴春林. 人精浆游离核酸作为睾丸/附睾表观遗传无创性标记物的研究[D]. 武汉: 华中科技大学, 2013.
    [25] Publicover S, Harper CV, Barratt C. [Ca2+]i signalling in sperm|[mdash]|making the most of what you've got[J]. Nat Cell Biol, 2007, 9(3): 235-42. doi: 10.1038/ncb0307-235
    [26] Nimlamool W, Bean BS, Lowe LJ. Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment[J]. Mol Reprod Dev, 2013, 80(6): 488-502.
    [27] 景晓玮, 邢荣威, 周其赵, 等. 弱精子症患者精子中CRISP2基因及蛋白的初步研究[J]. 中华男科学杂志, 2011, 17(3): 203-7. http://d.wanfangdata.com.cn/Periodical/zhnkx201103002
    [28] 周俊豪, 薛康颐, 陈明坤, 等. CRISP2基因及蛋白在弱精子症患者中的表达及其临床意义[J]. 南方医科大学学报, 2014, 34(10): 1528-33. doi: 10.3969/j.issn.1673-4254.2014.10.26
    [29] Arangasamy A, Kasimanickam VR, Dejarnette JM, et al. Association of CRISP2, CCT8, PEBP1 mRNA abundance in sperm and sire conception rate in Holstein bulls[J]. Theriogenology, 2011, 76(3): 570-7. doi: 10.1016/j.theriogenology.2011.03.009
    [30] Zaratiegui M, Irvine DV, Martienssen RA. Noncoding RNAs and gene silencing[J]. Cell,2007, 128(4): 763-76. doi: 10.1016/j.cell.2007.02.016
    [31] 周俊豪. CRISP2蛋白在弱精症精液精子中表达下调的分子机制及其临床意义[D]. 广州: 南方医科大学, 2015.
    [32] Comazzetto S, Di Giacomo M, Rasmussen KD, et al. Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci[J]. PLoS Genet, 2014, 10(10): e1004597-102. doi: 10.1371/journal.pgen.1004597
    [33] 周其赵. Mir-27a介导CRISP2表达导致弱畸形精子症的分子机制[D]. 广州: 南方医科大学, 2015.
    [34] 张 谊, 张 燕. miRNA与精子发生发育及精液质量关系的研究进展[J]. 黑龙江畜牧兽医, 2016,32(15): 63-5.
    [35] 王 成, 杨翠华. 不育男性患者特异精浆miRNA表达谱的筛选及其临床价值分析[C]//全国临床应用生物化学与分子生物学联合学术研讨会暨医学生化分会会员代表大会, 2011: 13-6.
    [36] 吴彩云, 王 成, 杨 琛, 等. 男性不育症患者精浆miR-106b水平变化及意义[J]. 临床检验杂志, 2013, 31(11): 859-62. http://d.wanfangdata.com.cn/Periodical/lcjyzz201311019
    [37] 陈德宇, 刘利敏, 黄天华. 弱精症患者精子miRNA表达谱的构建和分析[J]. 阜阳师范学院学报:自然科学版, 2009, 26(2): 47-51, 82. http://d.wanfangdata.com.cn/Periodical/fysfxyxb-zrkxb200902012
    [38] 刘利敏. 弱精症精子mRNA和miRNA差异表达谱的构建与分析[D]. 汕头: 汕头大学, 2009.
    [39] Zhou R, Wang R, Qin Y, et al. Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia[J]. Sci Rep, 2015, 14(5): 17743-6.
    [40] Lu J, Gu H, Tang Q, et al. Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population[J]. Sci Rep, 2016, 33(6): 19825-7.
    [41] Curry E, Safranski TJ, Pratt SL. Differential expression of porcine sperm microRNAs and their association with sperm morphology and motility[J]. Theriogenology, 2011, 76(8): 1532-9. doi: 10.1016/j.theriogenology.2011.06.025
    [42] Abu-Halima M, Backes C, Leidinger P, et al. MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns[J]. Fertil Steril, 2014, 101(1): 78-86, e2. doi: 10.1016/j.fertnstert.2013.09.009
    [43] Abu-Halima M, Ludwig N, Hart M, et al. Altered micro-ribonucleic acid expression profiles of extracellular microvesicles in the seminal plasma of patients with oligoasthenozoospermia[J]. Fertil Steril, 2016, 106(5): 1061-9. doi: 10.1016/j.fertnstert.2016.06.030
    [44] Tang D, Huang Y, Liu W, et al. Up-Regulation of microRNA-210 is associated with spermatogenesis by targeting IGF2 in male infertility[J]. Med Sci Monit, 2016, 22(5): 2905-10.
    [45] Li Z, Zheng Z, Ruan J, et al. Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression[J]. Oncotarget, 2016, 7(33): 52781-96. doi: 10.18632/oncotarget.v7i33
    [46] Zhang X, Wei R, Lou J, et al. Seminal plasma miR-122-3p and miR-141-5p stability and Its diagnosis value for idiopathic asthenospermia[J]. Chin J Med Genet, 2016, 33(3): 320-3.
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  • 收稿日期:  2017-09-05
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