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M2型丙酮酸激酶在肿瘤细胞中的多功能性

管明秀 管明华 张颖超 周云丽 郑大勇 王宝占

管明秀, 管明华, 张颖超, 周云丽, 郑大勇, 王宝占. M2型丙酮酸激酶在肿瘤细胞中的多功能性[J]. 分子影像学杂志, 2017, 40(3): 350-353. doi: 10.3969/j.issn.1674-4500.2017.03.27
引用本文: 管明秀, 管明华, 张颖超, 周云丽, 郑大勇, 王宝占. M2型丙酮酸激酶在肿瘤细胞中的多功能性[J]. 分子影像学杂志, 2017, 40(3): 350-353. doi: 10.3969/j.issn.1674-4500.2017.03.27
Mingxiu GUAN, Minghua GUAN, Yingchao ZHANG, Yunli ZHOU, Dayong ZHENG, Baozhan WANG. Versatility of pyruvate kinase M2 in tumor cells[J]. Journal of Molecular Imaging, 2017, 40(3): 350-353. doi: 10.3969/j.issn.1674-4500.2017.03.27
Citation: Mingxiu GUAN, Minghua GUAN, Yingchao ZHANG, Yunli ZHOU, Dayong ZHENG, Baozhan WANG. Versatility of pyruvate kinase M2 in tumor cells[J]. Journal of Molecular Imaging, 2017, 40(3): 350-353. doi: 10.3969/j.issn.1674-4500.2017.03.27

M2型丙酮酸激酶在肿瘤细胞中的多功能性

doi: 10.3969/j.issn.1674-4500.2017.03.27
详细信息
    作者简介:

    管明秀,硕士,主管技师,E-mail: xiusong2007@126.com

    通讯作者:

    王宝占,主管技师,E-mail: baozhanwang66@163.com

Versatility of pyruvate kinase M2 in tumor cells

  • 摘要: 丙酮酸激酶是葡萄糖代谢的关键限速酶。它主要有4种同工酶形式,L型、R型、M1型和M2型。M2型丙酮酸激酶主要表达于肿瘤细胞当中。肿瘤细胞对葡萄糖的代谢主要是通过有氧糖酵解的形式来完成,这一过程中M2型丙酮酸激酶起着关键限速酶的作用,同时在肿瘤细胞增殖过程中也起着调控信号转导的作用。M2型丙酮酸激酶为肿瘤细胞的增殖提供了能源和物质基础,它可以作为早期检测肿瘤的生物标记物。深入了解M2型丙酮酸激酶在肿瘤中的作用及机制可以为肿瘤靶向治疗提供新的思路。

     

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  • 收稿日期:  2017-03-05
  • 刊出日期:  2017-07-01

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