Clinical effect of two kinds of treatments on hand-foot syndrome in patients treated with capecitabine
-
摘要:
目的 比较湿润烧伤膏联合分级护理和润肤剂治疗卡培他滨致手足综合征的疗效。 方法 选取入住我院119例患者，按随机化原则分为两组，润肤剂组于化疗期间予润肤剂涂抹于患肢皮肤，执行常规皮肤护理方案；湿润烧伤膏分级护理组予湿润烧伤膏涂抹患肢皮肤，执行分级护理方案，比较两组患者化疗期间手足综合征发生率、反应程度以及手足综合征有效反应率。 结果 湿润烧伤膏分级护理组患者化疗期间手足综合征发生率和反应程度明显低于润肤剂组（P<0.05），治疗手足综合征有效率显著高于润肤剂组（P<0.05）。 结论 湿润烧伤膏联合分级护理可有效地降低卡培他滨致手足综合征的发生和反应程度，治疗手足综合征效果显著，促进化疗方案进行。 Abstract: Objective To compare the clinical effectiveness of the combination of moist exposed burn ointment (MEBO) and supportive care and skin barrier cream on the hand-foot syndrome(HFS) in patients treated with capecitabine. Methods A total of 119 patients from Nanfang hospital were randomly divided into treatment group and control group. Patients in control group were applied skin barrier cream and traditional skin care, while those of trentment group were treated with MEBO and supportive care. Results Compared with the control group, patients of the treatment group had a lower severity and incidence of HFS (P<0.05). It also had an effective ratio as well. Conclusion MEBO and supportive care decrease the severity and incidence of HFS caused by capectitabine more effectively compared with skin barrier cream.-
Key words:
- hand-foot syndrome /
- capecitabine /
- moist exposed burn ointment
-
表 1 两组患者手足综合征发生率比较（n, %）
组别 例数 手足综合征发生率 总发生率 0 I II III 湿润烧伤膏分段护理组 59 37（62.0） 13（22.8） 8（13.9） 1（1.3） 22（38.0） 润肤剂组 40 15（37.5） 13（32.5） 9（22.5） 3（7.5） 25（62.5） Z/χ2 -2.537 6.077 P 0.011 0.014 
下载: 导出CSV
表 2 两组患者手足综合征治疗效果比较（n）
组别 例数 疗效 有效率（%） 有效 无效 湿润烧伤膏分段护理组 19 18 1 94.7 润肤剂组 18 11 7 61.1 P（Fisher’s Exact Test） 0.019
下载: 导出CSV
-
[1] Hoff PM, Pazdur R, Lassere Y, et al. Phase II study of capecitabine in the patients with fluorouracil-resistant metastatic colorectal carcinoma[J]. J Clin Oncol, 2004, 22(11): 2078-83. doi: 10.1200/JCO.2004.05.072 [2] 刘晓艳, 张翠莲, 吴君德. 卡培他滨所致手足综合征的临床护理研究进展[J]. 河南中医, 2012, 32(6): 787-92. http://cdmd.cnki.com.cn/Article/CDMD-10026-2009089598.htm [3] Goyal R, Chalamalasetty SB, Madan K, et al. Acral and palmo-plantar hyperpigmentation in a patient with disseminated hepatocellular carcinoma[J]. Indian J Gastroenterol, 2008, 26(6): 292-3. [4] Reichardt P, von Minckwitz G, Thuss PC, et al. Multicenter phase II study of oral capecitabine (Xeloda) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapy[J]. Ann Oncol, 2003, 14(8): 1227-33. doi: 10.1093/annonc/mdg346 [5] Abushullaih S, Saad ED, Munsell M, et al. Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience[J]. Cancer Invest, 2002, 20(1): 3-10. doi: 10.1081/CNV-120000360 [6] 杨笑梅, 廖 鑫, 聂 新, 等. 卡培他滨致患者腹泻和手足综合征的防护[J]. 护理学杂志, 2014, 29(9): 37-9. http://www.cnki.com.cn/Article/CJFDTOTAL-HLXZ201409015.htm [7] 董元鸽, 陆箴琦, 杨 瑒. 卡培他滨致手足综合征的护理研究进展[J]. 护理研究, 2016,11(03): 275-8. doi: 10.3969/j.issn.1009-6493.2016.03.006 [8] 鞠小梅. 联合用药治疗急性放射性皮炎21例临床护理[J]. 齐鲁护理杂志, 2009, 15(7): 113-4. http://www.cnki.com.cn/Article/CJFDTOTAL-QLHL200907098.htm [9] Son HS, Lee WY, Lee WS, et al. Compliance and effective management of the hand-foot syndrome in colon cancer patients receiving capecitabine as adjuvant chemotherapy[J]. Yonsei Med J, 2009, 50(6): 796-802. doi: 10.3349/ymj.2009.50.6.796 [10] 湛永滋, 黄昌杰, 黄剑锋. 三乙醇胺防治鼻咽癌放射性皮肤损伤的临床观察[J]. 现代肿瘤医学, 2012, 20(1): 57-8. http://www.cnki.com.cn/Article/CJFDTOTAL-SXZL201201018.htm [11] 刘英新, 刘英华, 王 斐, 等. 中、晚期肝癌化疗所致手足综合征的护理体会[J]. 山东医药, 2009, 49(30): 25-8. doi: 10.3969/j.issn.1002-266X.2009.30.083 [12] 常忠莲, 万冬桂. 加味补阳还五汤防治希罗达所致手足综合征45例[J]. 中国中医药信息杂志, 2005, 12(6): 63-4. http://www.cnki.com.cn/Article/CJFDTOTAL-XXYY200506037.htm [13] Milano G, Etienne MC, Mari M, et al. Candidate mechanisms for capecitabine-related hand-foot syndrome[J]. Br J Clin Pharmacol, 2008, 66(1): 88-95. doi: 10.1111/j.1365-2125.2008.03159.x [14] Yen-Revollo JL, Goldberg RM, Mcleod HL. Can inhibiting dihydropyrimidine dehydrogenase limit hand-foot syndrome caused by fluoropyrimidines? [J]. Clin Cancer Res, 2008, 14(1): 8-13. doi: 10.1158/1078-0432.CCR-07-1225 [15] Scheithauer W, Blum J. Coming to grips with hand-foot syndrome. Insights from clinical trials evaluating capecitabine[J]. Oncology (Williston Park), 2004, 18(9): 1161-8. [16] Webster JD, How C, Harrold K. Palmar-plantar erythrodysesthesia (PPE): a literature review with commentary on experience in a cancer centre[J]. Eur J Oncol Nurs, 2007, 11(3): 238-46. doi: 10.1016/j.ejon.2006.10.004 [17] 张 艳, 俞国芳. 希罗达致手足综合征的临床护理[J]. 浙江预防医学, 2007, 19(5): 87-8. http://www.cnki.com.cn/Article/CJFDTOTAL-HLJH200616043.htm [18] 匡卫华. 湿润烧伤膏治疗希罗达所致手足综合征的疗效观察[J]. 实用癌症杂志, 2008, 23(6): 655-7. http://www.cnki.com.cn/Article/CJFDTOTAL-SYAZ200806039.htm -
点击查看大图
表(2)
计量
- 文章访问数: 553
- HTML全文浏览量: 247
- PDF下载量: 2
- 被引次数: 0
