Efficacy of hemabate in the ovarian endometriosis cyst removal surgery under laparoscope
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摘要:
目的 探讨在腹腔镜下卵巢子宫内膜异位囊肿剔除术中子宫肌层注射欣母沛的安全性和可行性。 方法 将厚街医院腹腔镜下卵巢子宫内膜异位囊肿剥除术68例患者分为子宫肌层注射欣母沛组(研究组)31例，未使用欣母沛组(对照组)37例，比较两组的手术时间、术中出血量、术后并发症、术后最高体温、血红蛋白及血压变化等指标。 结果 研究组的手术时间平均为107.7±13.2 min，术中出血量平均为114.7±28.1 mL。对照组的手术时间平均为126.1±16.0 min，术中出血量平均为188.6±57.4 mL，差异有统计学意义(P<0.05)。术前术后血红蛋白的变化，研究组变化较小(P<0.05)。研究组的术后最高体温为36.9±0.43 ℃，肛门排气时间为18.9±4.56 h，住院时间7.1±0.79 d。对照组的术后体温为36.7±0.42 ℃，肛门排气时间为19.3±4.40 h，住院时间7.3±0.96 d，两者差异无统计学意义(P>0.05)。研究组的少数患者出现血压一过性升高。术后并发症研究组低于对照组，但差异无统计学意义(P>0.05)。 结论 腹腔镜下卵巢子宫内膜异位囊肿剔除术中使用欣母沛，能减少术中出血，缩短手术时间，减少术后的并发症，是一种安全、可行的术中用药方法。 -
关键词:
- 腹腔镜 /
- 欣母沛 /
- 卵巢子宫内膜异位囊肿
Abstract:Objectives To investigate the feasibility and safety of ovarian endometriosis cyst removal surgery injecting hemabate into myometrium in laparoscopy. Methods A total of 68 patients with laparoscopic ovarian endometriosis cyst stripping were enrolled into the study from houjie hospital. They were freely classified into two groups, and 31 patients injected hemabate into myometrium (study group), and 37 patients did not use hemabate (control group). The operative time, intraoperative blood loss, blood pressure, postoperative change of hemoglobin, surgical complications and postoperative highest temperature of the two groups were compared. Results The average operative time of study group was 107.7±13.2 min, and the average blood loss during the operation was 114.7±28.1 mL. The average operative time of control group was 126.1±16.0 min, and the average blood loss during the operation was 188.6±57.4 mL, the difference was statistically significant (P<0.05). The rate of the postoperative change of hemoglobin in study group was significantly less than that in control group (P<0.05). The average postoperative highest temperature of study group was 36.9±0.43 ℃, the average postoperative exhaust time was 18.9±4.56 h, and the average postoperative hospitalization time was 7.1±0.79 d. The average postoperative highest temperature of control group was 36.7±0.42 ℃, the average postoperative exhaust time was 19.3±4.40 h, and the average postoperative hospitalization time was 7.3±0.96 d, the difference was not statistically significant (P>0.05). But few patients of study group had a transient high blood pressure. No significant differences existed surgical complications (P>0.05). Conclusion Using hemabate of ovarian endometriosis cyst surgery in laparoscopy can reduce intraoperative bleeding and postoperative complications, and shorten operation time. It is a safe and feasible method for intraoperative medication in laparoscopy. -
Key words:
- laparoscopy /
- hemabate /
- ovarian endometriosis cyst
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表 1 两组患者的一般情况(n,
$\, \overline{{x}}{{±}}{{s}}$ )组别 n 年龄(岁) 囊肿直径(mm) 下腹部手术史（例） 内科合并症（例） 激素治疗情况（例） 单双侧 ASRM 单侧 双侧 Ⅲ期 Ⅳ期 研究组 31 35.6±2.9 5.7±0.8 5 2 2 18 13 21 10 对照组 37 35.4±2.8 5.5±0.7 6 2 2 22 15 25 12 t(χ2) 0.221 0.809 0.000 0.044 0.044 0.014 0.000 P 0.826 0.421 0.992 0.834 0.834 0.907 0.988 
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表 2 研究组术中用药前后的血压变化(
$\, \overline{{x}}{{±}}{{s}}$ )用药时间 收缩压(mmHg) 舒张压(mmHg) 用药前 111.1±8.3* 71.5±6.4* 用药15 min 121.4±15.9 76.3±9.8 用药30 min 113.0±8.7* 72.4±6.3* 用药45 min 111.2±7.5* 71.0±6.3* *P<0.05vs 用药15 min.
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表 3 两组患者术中及术后比较(
$\, \overline{{x}}{{±}}{{s}}$ )组别 n 术中出血量(mL) 手术时间(min) 术后第1天体温(℃) 肛门排气时间(h) 住院时间(d) 术前术后Hb差值(g/L) 研究组 31 114.7±28.1 107.7±13.2 36.9±0.43 18.9±4.56 7.1±0.79 7.06±1.29 对照组 37 188.6±57.4 126.1±16.0 36.7±0.42 19.3±4.40 7.3±0.96 10.6±2.46 t -6.542 -5.073 1.238 -0.307 -0.803 -7.154 P 0.000 0.000 0.220 0.76 0.425 0.000
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