Kisspeptins 对下丘脑-垂体-性腺轴作用机制新进展

石明晴; 周惠芳

doi:10.3969/j.issn.1674-4500.2017.01.28

Kisspeptins 对下丘脑-垂体-性腺轴作用机制新进展

doi: 10.3969/j.issn.1674-4500.2017.01.28

石明晴^1,,
周惠芳²

1.
丽水市中医院，浙江丽水 3230002
2.
南京中医药大学第一临床医学院，江苏南京 210029

详细信息

作者简介:
石明晴，硕士，主治医师，E-mail: 936391460@qq.com

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- 文章访问数: 966
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- 被引次数: 0
出版历程
- 收稿日期: 2016-07-14
- 刊出日期: 2017-01-01

New progress in the mechanism of Kisspeptins on hypothalamic pituitary gonadal axis

Mingqing SHI^1
,,
Huifag ZHOU²

1.
Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province, Lishui 323000, China
2.
The first clinical medical college of Nanjing

摘要

摘要: 近年来，Kisspeptins 的发现使人们对调控青春期和生殖的神经内分泌轴有了新的认识。Kisspeptins 不仅是促进 GnRH 分泌的上游因子，而且调控下丘脑-垂体-卵巢轴，主要表现在促性腺激素分泌的调节、青春期的启动以及生殖功能的调控等方面。通过对健康人群及生殖内分泌紊乱患者的观察，发现 Kisspeptins 可以刺激 GnRH 分泌，后者诱导 LH 分泌，而且增强 LH 的脉冲频率。这些研究表明 Kisspeptins 将成为生殖内分泌研究的热点，并为生殖内分泌疾病提供新的治疗策略。目前许多动物试验研究证明 Kisspeptins 在以下几个方面也存在潜在的作用，如卵巢的功能的调节、胚胎植入及胎盘的形成。本文将集中收集关于 Kisspeptins 调控 GnRH 的脉冲式分泌的现有的依据，特别是青春期启动及生殖内分泌方面。
- Kisspeptins /
- 下丘脑-垂体-性腺轴 /
- GnRH分泌 /
- 青春期启动 /
- 生殖内分泌功能
Abstract: In recent years, the discovery of Kisspeptins makes people have a new understanding of the neuroendocrine axis regulating puberty and reproduction. Kisspeptins is not only the upstream factor that promotes the secretion of GnRH, but also regulates the hypothalamic pituitary ovary axis, which is mainly manifested in the regulation of gonadotropin secretion, the initiation of puberty and the regulation of reproductive function. By observing the healthy population and reproductive endocrine disorders, we found that Kisspeptins can stimulate the secretion of GnRH, which induces LH secretion, and enhance the pulse frequency of LH. At present, many animal experiments have proved that Kisspeptins has the potential function in the following aspects, such as the function of ovary, embryo implantation and placenta formation. This article will focus on the existing basis for the Kisspeptins regulation of GnRH pulse type secretion, in particular, the initiation of puberty and reproductive endocrine aspects.
- kisspeptins /
- hypothalamic pituitary gonadal axis /
- GnRH secretion /
- puberty initiation /
- reproductive and endocrine function

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参考文献(47)

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Kisspeptins 对下丘脑-垂体-性腺轴作用机制新进展

doi: 10.3969/j.issn.1674-4500.2017.01.28

作者简介:
石明晴，硕士，主治医师，E-mail: 936391460@qq.com

计量

New progress in the mechanism of Kisspeptins on hypothalamic pituitary gonadal axis

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目录

留言板

Kisspeptins 对下丘脑-垂体-性腺轴作用机制新进展

doi: 10.3969/j.issn.1674-4500.2017.01.28

作者简介: 石明晴，硕士，主治医师，E-mail: 936391460@qq.com

计量

出版历程

New progress in the mechanism of Kisspeptins on hypothalamic pituitary gonadal axis

计量

出版历程

目录

作者简介:
石明晴，硕士，主治医师，E-mail: 936391460@qq.com