The efficiency of pre-operative CD8+CD28-T cells to predict recurrence for patients with
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摘要:
目的探索术前CD8+CD28-调节性T细胞（Treg）含量在预测肾细胞癌（RCC）患者术后复发的效能。 方法术前检测33例接受肾癌根治术的RCC患者外周血CD8+CD28-Treg含量，术后进行为期60个月的随访，观察CD8+CD28-Treg与复发的关系，并与术前中性粒/淋巴细胞比值（NLR）进行对照。 结果共有9例患者出现复发，占27.27%，平均复发时间均数为术后24个月；复发患者的CD8+CD28-Treg及NLR数值均大于非复发组（P=0.034、0.041）。受试者工作曲线分析显示CD8+CD28-Treg及NLR均与RCC存在显著相关性，曲线下面积分别为0.819及0.703（P=0.004及0.021），且当CD8+CD28-Treg为8.21%时，其预测复发的敏感度为92.6%，特异度为90.5%，显著高于NLR。 结论术前CD8+CD28-Treg在预测RCC患者术后复发具有较理想的准确度，对于术前该细胞百分含量高于8.21%的患者需在术后2年内加强随访。 -
关键词:
- 肾细胞癌 /
- CD8+CD28-调节性T细胞 /
- 中性粒/淋巴细胞比值 /
- 受试者工作曲线 /
- 敏感度 /
- 特异度
Abstract:ObjectiveTo explore the efficiency of pre-operative CD8+CD28-T cells to predict recurrence for patients with renal cell carcinoma (RCC). MethodsPreoperative detection of 33 cases with kidney cancer in RCC patients with peripheral blood CD8+CD28-Treg content, for 60 months of follow-up, postoperative observation of CD8+CD28-Treg and recurrence relations, and compared with preoperative neutral grain/lymphocyte ratio (NLR) were compared. ResultsA total of 9 cases of patients with recurrence, accounted for 27.27%, the average recurrence time mean for 24 months after surgery; Patients with recurrence of CD8 + CD28-Treg and NLR numerical group were greater than the recurrence (P=0.034, 0.041).Subjects work curve (ROC) analysis showed that CD8+CD28- there was a significant correlation with RCC Treg and NLR, the area under the curve (AUC) were 0.819 and 0.703 (P=0.004 and 0.004), and when CD8+ CD28-Treg was 8.21%, the sensitivity of the recurrence of its predictions for 92.6%, 90.5%, significantly higher than that of NLR. ConclusionPreoperative CD8+CD28-Treg in predicting recurrence of patients with RCC has ideal accuracy, for the cell percentage is higher than 8.21% of patients with preoperative need strengthen follow-up of 2 years after surgery. -
表 1 两组患者CD8+CD28-Treg及NLR的数值比较
指标 CD8+CD28-Treg (%) NLR 复发组 5.16±1.32 2.13±0.54 未复发组 6.63±1.51 3.65±1.23 t -2.019 -1.873 P 0.034 0.041 
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