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子痫前期相关循环microRNAs的研究进展

杨龙江,  杜丹,  傅强,  李志樑

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文章导航 > 分子影像学杂志  > 2016 >  39(1): 47-50
杨龙江, 杜丹, 傅强, 李志樑. 子痫前期相关循环microRNAs的研究进展[J]. 分子影像学杂志, 2016, 39(1): 47-50. doi: 10.3969/j.issn.1674-4500.2016.01.15
引用本文: 杨龙江, 杜丹, 傅强, 李志樑. 子痫前期相关循环microRNAs的研究进展[J]. 分子影像学杂志, 2016, 39(1): 47-50. doi: 10.3969/j.issn.1674-4500.2016.01.15
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Longjiang YANG, Dan Du, Qiang FU, Zhiliang LI. Research progress of circulating microRNAs in preeclampsia[J]. Journal of Molecular Imaging, 2016, 39(1): 47-50. doi: 10.3969/j.issn.1674-4500.2016.01.15
Citation: Longjiang YANG, Dan Du, Qiang FU, Zhiliang LI. Research progress of circulating microRNAs in preeclampsia[J]. Journal of Molecular Imaging, 2016, 39(1): 47-50. doi: 10.3969/j.issn.1674-4500.2016.01.15
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子痫前期相关循环microRNAs的研究进展

doi: 10.3969/j.issn.1674-4500.2016.01.15
  • 1.

    南方医科大学珠江医院心血管内科，广东 广州 510282

  • 2.

    广州市海珠区妇幼保健院妇产科，广东 广州 510240

基金项目: 

广州市科技计划项目 20130000091

详细信息
    作者简介:

    杨龙江,在读博士生，E-mail: chinacqjjfox@126.com

    通讯作者:

    李志樑，主任医师，E-mail: lizhiliang020@126.com

Research progress of circulating microRNAs in preeclampsia

  • 1.

    Department of Cardiovascuology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

  • 2.

    Department of Gynecologyand Obstetrics, Haizhu Maternal and Child Health Hospital, Guangzhou 510240, China

    摘要
  • 摘要: 子痫前期在全球范围内是导致孕妇和胎儿死亡的主要原因之一，其发病机制仍未完全阐明。microRNAs是一类具有调控基因转录后表达的非编码小RNA，参与细胞的增殖、分化、凋亡等重要生物功能，近年来研究表明其可作为多种疾病的诊断标志物与治疗靶点。子痫前期患者胎盘及循环中存在一系列表达失衡的microRNAs，表明microRNAs可能在子痫前期的发生发展中发挥重要作用。本文就近年子痫前期相关循环microRNAs的研究概况做一综述。

     

    Abstract: Preeclampsia is one major cause of maternal and fetus morbidity and mortality in the world, the pathogenesis is stillunclear. MicroRNAs are non-coding small RNA that can regulate the gene expression and participate in many importantbio-functions such as cellular proliferation, differentiation and apoptosis. Recently, studies demonstrate that microRNAs canbe use as diagnosis biomarkers and treating targets for many diseases. The imbalance of microRNAs in placenta and circulationof PE patients demonstrate that microRNAs may play an important role in pathogenesis of PE. This review summarizescurrent studies on circulating microRNA in PE.

     

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    • 参考文献(33)
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  • 收稿日期:  2015-12-01
  • 刊出日期:  2016-01-01

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