The effectiveness of combination of biafine and sanyrene and hirudoid cream on radiation dermatitis in patients with nasopharyngeal carcinoma
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摘要:
目的 比较联合应用比亚芬和赛肤润乳膏与喜疗妥乳膏预防鼻咽癌患者放射性皮炎的效果。 方法 选取2014年3~12月入住我院80例患者，按入院顺序随机分为两组，喜疗妥组于放疗前后予喜疗妥乳膏涂抹于照射野皮肤，实验组于放疗前予赛肤润乳膏，于放疗后予比亚芬涂抹照射野皮肤，比较两组患者化疗期间阳性放射性皮炎发生率、放射性皮炎反应程和Ⅱ度及以上放射性皮炎出现时间。 结果 实验组患者化疗期间阳性放射性皮炎发生率明显低于喜疗妥组（P＜0.05）；放射性皮炎反应程显著低于喜疗妥组（P＜0.05）；Ⅱ度及以上放射性皮炎出现时间明显推迟（P＜0.05）。 结论 鼻咽癌患者联合应用比亚芬和赛肤润乳膏不仅能有效地降低放射性皮肤炎的发生，还能减轻放射性皮炎的反应程度，减少患者的疼痛。 Abstract:Objective To compare the effectiveness of the combination of Biafine and Sanyrene and hirudoid cream on the postirradiation dermatitis in nasopharyngeal carcinoma patients. Methods A total of 80 patients from Nanfang hospital were randomly divided into treatment group and hirudoid group according to the sequence of admission. Patients in two groups were applied hirudoid cream, and the combination of biafine cream and sanyrene before and after radiotherapy, respectively. Results Compared with the hirudoid group，patients of the treatment group had a lower severity and incidence of radiation dermatitis (P<0.05). Conclusion The combination of Biafine and Sanyrene decreases the severity and incidence of radiation dermatitis more effectively compared with hirudoid cream. -
Key words:
- radiation dermatitis /
- biafine /
- sanyrene /
- hirudoid cream
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表 1 两组患者化疗不良反应比较(n=40)
组别 放射性皮肤损伤发生率(n,%) 皮肤炎(n,%) 0 级 Ⅰ级 Ⅱ级 Ⅲ级 Ⅳ级 阳性 阴性 实验组 0(0) 24(60) 16(40) 0(0) 0(0) 16(40) 24(60) 喜疗妥组 0(0) 14(35) 22(55) 3(7.5) 1(2.5) 26(65) 14(35) Z值 -2.069 -2.225 P值 <0.05 <0.05 
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