Value of serum LDH,TPS,CEA and β2-MG in the diagnosis of non-Hodgkin's lymphoma
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摘要:
目的研究血清乳酸脱氢酶（LDH）、组织多肽特异性抗原（TPS）、癌胚抗原（CEA）和β2-微球蛋白（β2-MG）在非霍奇金淋巴瘤（NHL）诊断中的价值 方法分别采用速率法和酶联免疫吸附法测定62例NHL患者、8例淋巴结良性病患者及40例健康体检者血清LDH、TPS、CEA和β2-MG水平。 结果（1）NHL组血清LDH、TPS、CEA和β2-MG水平明显升高，与淋巴结良性病组和健康体检组比较差异有统计学意义（P<0.05）；淋巴结良性病组和健康体检组比较，四种肿瘤标志物水平差异无统计学意义（P>0.05）；（2）血清LDH、TPS、CEA和β2-MG水平在NHL中的高度恶性组、中度恶性组、低度恶性组之间差异无统计学意义(P>0.05)。 结论血清肿瘤标志物LDH、TPS、CEA和β2-MG的检测，对NHL的诊断具有重要参考价值。 Abstract:Objective To explore the clinical value of serum lactic dehydrogenate(LDH), tissue polypeptide specific antigen (TPS), carcinoembryonic antigen(CEA),andβ2-microglobulin(β2-MG) in the diagnosis of non-Hodgkin,s lymphoma(NHL). Methods The serum level of LDH was determined with automatic biochemical analyzer and TPS,CEA and β2-MG levels were determined by enzyme-linked immumosorbent assay(ELISA) in 62 NHL patients ,8 lymphatic neagative patients and 40 healthy persons. Results (1)The serum levels of LDH、TPS、CEA and β2-MG in NHL patients were higher than other groups （P<0.05）; (2)There was no statistical significance in examining the serum levels of LDH、TPS、CEA and β2-MG in NHL patients in high malignancy group, middle malignancy group and low malignancy group(P>0.05). Conclusion The detection of serum LDH、TPS、CEAand β2-MG is of value in diagnosis in patients with NHL. -
表 1 NHL组、淋巴结良性病组和健康体检组4 种肿瘤标志物水平比较Md(Md25%,Md75%）
组别 n LDH TPS CEA β2-MG NHL组 62 190.00(151.00,277.50) 64.00(37.55,114.25) 0.65(0.24,2.39) 2.10(1.34,3.68) 淋巴结良性病组 8 170.00(160.00,192.00) 42.05(18.78,82.83) 0.30(0.25,0.55) 2.10(0.90,2.70) 健康查体组 40 165.50(142.00,176.75) 38.50(4.16,46.48) 0.30(0.06,0.60) 1.40(0.80,1.80) P 0.019 0 0.045 0.005 Md为中位数. 
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表 2 NHL组3 种不同恶性程度中4种肿瘤标志物水平比较Md(Md25%,Md75%）
组别 n LDH TPS CEA β2-MG 低度恶性组 7 182.00(144.00,393.00) 84.95(66.98,131.20) 0.71(0.24,4.01) 3.15(1.35,7.21) 中度恶性组 48 189.00(142.00,264.00) 61.20(35.50,89.35) 0.65(0.24,2.53) 1.91(1.32,3.36) 高度恶性组 7 286.00(191.50,667.80) 95.00(41.25,184.00) 0.30(0.10,0.50) 3.1 P 0.251 0.338 0.365 （2.70,5.15 Md为中位数.
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