ACE 基因 I/D 多态性与动脉血栓性脑梗死的关联性研究

何深文; 李旺英; 林南生; 刘凯; 黄海威

doi:10.3969/j.issn.1674-4500.2015.03.08

ACE 基因 I/D 多态性与动脉血栓性脑梗死的关联性研究

doi: 10.3969/j.issn.1674-4500.2015.03.08

1.
内科二区，广东省佛山市顺德区均安医院, 广东佛山 528329
2.
超声科，广东省佛山市顺德区均安医院, 广东佛山 528329
3.
中山大学附属第一医院神经科，广东广州510080

基金项目:

广东省佛山市卫生局医学科研课题 2011498

详细信息

作者简介:
何深文，医学硕士，主治医师，E-mail: shenwenh@126.com

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出版历程
- 收稿日期: 2015-02-25
- 刊出日期: 2015-08-01

Association between ACE gene I/D polymorphism and atherothrombotic infarction

1.
Department of Internal Medicine,un-an Hospital, Foshan 528329, China
2.
Department of Ultrasonic Medicine, Jun-an Hospital, Foshan 528329, China
3.
Department of Neurology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China

摘要

摘要: 目的研究血管紧张素转换酶（ACE）基因I/D多态位点与动脉血栓性脑梗死的关联性及相关机制。方法选取动脉血栓性脑梗死患者112例和年龄、性别匹配的对照组180例，采用PCR-AFLP技术对ACE基因I/D位点进行分型。结果单因素分析提示病例组收缩压水平（138.1±19.7 mmHg）显著高于对照组（126.6±20.6 mmHg）（t=4.716，P<0.001）；病例组舒张压水平（88.9±10.1 mmHg）显著高于对照组（79.9±10.0 mmHg）（t=7.450，P<0.001）。病例组中ACE基因I/D位点D等位基因频率和DD基因型频率分布均显著高于对照组（等位基因：χ²=4.953，P=0.026; 基因型：χ²=6.303，P=0.043）。病例组和对照组中ACE基因I/D位点基因型DD携带者收缩压及舒张压水平显著高于基因型ID及II携带者。结论ACE基因I/D位点等位基因D可能是汉族人群动脉血栓性脑梗死遗传易感基因。等位基因D可能通过升高个体血压的机制导致动脉血栓性脑梗死发生。
- 血管紧张素转换酶 /
- 基因多态性 /
- 血压 /
- 动脉血栓性脑梗死
Abstract: Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene I/D polymorphism and atherothrombotic infarction. Methods 112 patients with atherothrombotic infarction and 180 age, sex-matched healthy subjects were recruited. Genotypes were detected by PCR-AFLP. Results Univariate analysis revealed that systolic blood pressure (SBP) levels for patients (138.1 ± 19.7mm Hg) were significantly higher than those for healthy controls (126.6 ± 20.6 mmHg) (t=4.716, P<0.001), and diastolic blood pressure (DBP) levels for patients (88.9±10.1 mmHg) were significantly higher than those for healthy controls (79.9 ± 10.0 mmHg) (t=7.450, P<0.001). Allele D frequency and distribution of frequency for genotype DD of ACE gene I/D polymorphism for patients were significantly higher than those for healthy controls (allele: x2= 4.953, P=0.026; genotype: x2=6.303, P=0.043). In both groups, the SBP and DBP levels for genotype DD were significantly higher than those for genotype ID and II. Conclusion Allele D of ACE gene I/D polymorphism plays a role in elevating blood pressure and may be a major risk factor for atherothrombotic infarction.
- a0ngiotensin converting enzyme /
- gene polymorphism /
- blood pressure /
- atherothrombotic infarction

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表 1 病例组与对照组ACE基因I/D 多态位点基因型与等位基因频率分布（%）

组别	基因型^①				等位基因^②
组别	n	II	ID	DD	n	I	D
病例组	112	24 (21.4)	66 (58.9)	22 (19.6)	224	114 (50.9)	110 (49.1)
对照组	180	63 (35.0)	91 (50.6)	26 (14.4)	360	217 (60.3)	143 (39.7)
①χ²=6.303, P=0.043; ②χ²=4.953, P=0.026

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表 2 病例组与对照组ACE基因I/D 多态位点基因型与危险因素的关系

危险因素	病例组			对照组
危险因素	II (n=24)	ID (n=66)	DD (n=22)	II (n=63)	ID (n=91)	DD (n=26)
收缩压（mmHg）	130.8±19.2	138.0±19.6	146.4±21.1^①	121.2±18.4	126.3±20.8	140.7±21.5^③
舒张压（mmHg）	84.0±10.2	88.7±9.8	94.6±10.3^②	76.8±9.7	80.9±10.2	84.1±10.8^④
①DDvsID+II: t=2.186, P=0.031; ②DDvsID+II: t=3.010, P=0.003; ③DDvsID+II: t=3.882, P<0.001; ④DDvsID+II: t=2.284, P=0.024

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参考文献(10)

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ACE 基因 I/D 多态性与动脉血栓性脑梗死的关联性研究

doi: 10.3969/j.issn.1674-4500.2015.03.08

作者简介:
何深文，医学硕士，主治医师，E-mail: shenwenh@126.com

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Association between ACE gene I/D polymorphism and atherothrombotic infarction

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ACE 基因 I/D 多态性与动脉血栓性脑梗死的关联性研究

doi: 10.3969/j.issn.1674-4500.2015.03.08

作者简介: 何深文，医学硕士，主治医师，E-mail: shenwenh@126.com

计量

出版历程

Association between ACE gene I/D polymorphism and atherothrombotic infarction

计量

出版历程

目录

作者简介:
何深文，医学硕士，主治医师，E-mail: shenwenh@126.com