Antinuclear antibody detection in the clinical diagnosis of diffuse connective tissue disease
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摘要:
目的通过抗核抗体谱检测结果对弥漫性结缔组织病患者临床诊断进行评价。 方法回顾分析246例弥漫性结缔组织病和160例非弥漫性结缔组织病住院患者自身抗体检测结果。 结果在各种弥漫性结缔组织病中抗核抗体谱阳性检出率间差异有统计学意义，在系统性红斑狼疮患者中，抗dsDNA抗体阳性率为44.1%，抗Sm抗体阳性率为47%；在混合性结缔组织病中抗UIRNP抗体阳性率达96.4%；在干燥综合征患者中抗SSA和抗SSB抗体阳性率为68.2%和59.1%；在系统性硬化病患者中抗Scl-70抗体阳性率为41.4%；重叠综合征抗dsDNA、抗Sm、抗UIRNP、抗SSA抗体的阳性率为45.4%、18.2%、45.4%、18.2%。 结论抗核抗体谱检测对各种弥漫性结缔组织病有重要的鉴别诊断意义。 Abstract:ObjectiveTo evaluate the clinical diagnosis of diffuse connective tissue disease patients by antinuclear antibody test Results. MethodMethods a retrospective analysis of 246 cases of diffuse connective tissue diseases and 160 cases of non diffuse connective tissue disease detection in hospitalized patients with autoantibody. Result In a variety of diffuse connective tissue disease antinuclear antibody positive rate between the difference has statistical significance, in systemic lupus erythematosus patients, the positive rate of anti dsDNA antibody was 44.1%, the positive rate of anti Sm antibody positive rate was 47%; in mixed connective tissue disease in anti UIRNP antibody was 96.4% in patients with Sjogren syndrome; syndrome of anti SSA and anti SSB antibody positive rate was 68.2% and 59.1%; in patients with systemic sclerosis in anti Scl-70 antibody positive rate was 41.4%; overlap syndrome, anti dsDNA, anti Sm, anti UIRNP, anti SSA antibody positive rate was 45.4%, 18.2%, 45.4%, 18.2%. ConclusionThere are important in the differential diagnosis of antinuclear antibody spectrum detection of diffuse connective tissue disease. -
Key words:
- diffuse connective tissue disease /
- anti nuclear antibody
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表 1 弥漫性结缔组织病患者与对照组ANA抗体谱阳性率比较（n, %）
疾病 n 抗dsDNA抗体 抗组蛋白抗体 抗Sm抗体 抗UIRNP抗体 抗SSA抗体 抗SSB抗体 抗Scl-70抗体 抗CENP-B抗体 抗J0-1抗体 SLE 34 15(44.1) 6(17.6) 16(47) 14(41.2) 11(32.4) 5(14.7) 0 3(8.8) 0 RA 29 2(6.9) 2(6.9) 0 3(10.3) 4(13.8) 1(3.5) 0 1(3.5) 2(6.9) MCTD 28 7(25) 4(14.3) 3(10.7) 27(96.4) 5(17.9) 0 0 0 0 PSS 87 0 0 0 0 3(3.5) 2(2.3) 36(41.4) 12(13.8) 0 DM/PM 35 2(5.7) 0 0 3(8.6) 6(17.10) 0 0 2(5.7) 11(31.4) SS 22 0 0 0 0 15(68.2) 13(59.1) 0 0 0 OLs 11 5(45.4) 2(18.2) 5(45.4) 2(18.2) 1(9) 0 0 0 0 对照组 160 2(1.3) 2(1.3) 2(1.3) 1(0.6) 7(4.4) 4(2.5) 1(0.6) 2(1.3) 0 χ2 1380.745 51.631 107.916 156.12 90.673 202.076 21.372 21.631 7.818 P < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 < 0.05 
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