DNA methylation in schizophrenia susceptibility genes
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摘要: 遗传因素和环境因素共同作用于精神分裂症的发生。环境因素介助于表观遗传学机制修饰遗传因素,继而影响疾病的发生和发展。以往的遗传学研究已经发现了多个精神分裂症易感基因,本文将对这些易感基因的DNA甲基化修饰在精神分裂症发生和发展中的作用进行综述。Abstract: Recent studies have found a number of schizophrenia susceptibility genes. The interplay between genetic variation and DNA methylation of these susceptibility genes underlies the pathophysiology of schizophrenia. Associations of DNA methylations of these susceptibility genes with schizophrenia were reviewed in the current paper.
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Key words:
- DNA methylation /
- schizophrenia /
- susceptibility genes
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