Roles of nitrotyrosine in diabetic nephropathy
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摘要: 硝基酪氨酸被认为是体内氧化应激的标志物,可用于指导糖尿病及其并发症的临床诊断及治疗。而最近的研究表明,硝基酪氨酸不仅是糖尿病时的代谢产物及糖尿病慢性并发症的风险预测因子,本身还具有病理生理学活性。本文就硝基酪氨酸的生成、病理作用及其在糖尿病肾病发生、发展中的作用作一综述。Abstract: Nitrotyrosine is a product of of tyrosine nitration mediated by peroxynitrite anion and nitrogen dioxide, which is well acknowledged as a significant factor in diabetes mellitus(DM). It is regarded as a marker of oxidative stress(OS) and a risk predictor of chronic complications of DM to assist clinical diagnosis and therapy. Present researches have found that NT has its own pathological activities, such as causing damages of protein, mitochondria and cell. Thus, in this paper, generation pathology effect of NT, and its role in establishment and development in DM are reviewed.
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Key words:
- 3-nitrotyrosine /
- diabetic nephropathy /
- oxidative stress
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[1] Ceriello A, Piconi L, Esposito K, et al. Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes[J]. Diabetes Care, 2007, 30(7): 1694-8. doi: 10.2337/dc07-0318 [2] Zhang HM, Dang H, Kamat A, et al. Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes[J]. PLoS One, 2012, 7: e32746. doi: 10.1371/journal.pone.0032746 [3] Chi Q, Wang T, Huang K. Effect of insulin nitration by peroxynitrite on its biological activity[J]. Biochem Biophys Res Commun, 2005, 330(3): 791-6. doi: 10.1016/j.bbrc.2005.03.034 [4] 马邵, 武传龙. 2型糖尿病患者血清3-硝基酪氨酸的检测及其意义[J]. 临床检验杂志, 2009, 4(4): 308-9. http://www.cnki.com.cn/Article/CJFDTOTAL-ZGSQ201234265.htm [5] Turko IV, Murad F. Protein nitration in cardiovascular diseases[J]. Pharmacol Rev, 2002(54): 619-34. [6] Pietraforte D, Minetti M. Direct ESR detection or peroxynitrite-induced tyrosine-centred protein radicals in human blood plasma[J]. Biochem J, 1997, 325(3): 675-84. doi: 10.1042/bj3250675 [7] Peluffo H, Shacka JJ, Ricart K, et al. Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine[J]. J Neurochem, 2004, 89(3): 602-12. doi: 10.1046/j.1471-4159.2004.02363.x [8] Chang W, Webster DR, Salam AA, et al. Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation[J]. J Biol Chem, 2002, 277(34): 30690-8. doi: 10.1074/jbc.M204930200 [9] van der Vliet A, Eiserich JP, Halliwell B, et al. Formation of reactive Nitrogen species during peroxidase-catalyzed oxidation of nitrite[J]. J Biol Chem, 272: 7617-25. doi: 10.1074/jbc.272.12.7617 [10] Phung AD, Soucek K, Kubala L, et al. Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells[J]. Eur J Cell Biol, 2006, 85(12): 1241-52. doi: 10.1016/j.ejcb.2006.05.016 [11] Vattemi G, Mechref Y, Marini M, et al. Increased protein nitration in mitochondrial diseases: evidence for vessel wall involvement[M]. 2011: 002964. [12] 李雅东, 张劲松, 杨凯, 等. 微管蛋白酪氨酸连接酶类似物12通过干扰微管蛋白酪氨酸硝基化促进Hep-2细胞生长[J]. 中国生物化学与分子生物学报, 2012, 8: 728-32. [13] Kartha GK, Moshal KS, Sen U, et al. Renal mitochondrial damage and protein modification in type-2 diabetes[J]. Acta Diabetol, 2008, 45(2): 75-81. doi: 10.1007/s00592-008-0025-z [14] Yun B, Lee H, Ghosh M, et al. Serine hydrolase inhibitors block necrotic cell death by preventing Calcium overload of the mitochondria and permeability transition pore formation[J]. J Biol Chem, 2014, 289(3): 1491-504. doi: 10.1074/jbc.M113.497651 [15] Brookes PS, Darley-Usmar VM. Role of Calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition[J]. Am J Physiol Heart Circ Physiol, 2004, 286(1): H39-46. http://d.scholar.cnki.net/detail/SJPD2059_U/SJPD12102401427144 [16] 李菁, 景亮, 廖丽君, 等. 3-硝基酪氨酸对大鼠血管平滑肌细胞肾上腺素能受体α1D mRNA表达的影响[J]. 中华麻醉学杂志, 2005, 25(1): 40-2. [17] 景亮, 李菁, 赵纲, 等. 硝基酪氨酸对大鼠α-肾上腺素能受体介导血管反应性的影响[J]. 中华麻醉学杂志, 2004, 24(12): 913-5. http://d.wanfangdata.com.cn/Periodical/zhmzxzz98200412008 [18] Murata M, Kawanishi S. Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation[J]. Biochem Biophys Res Commun, 2004, 316(1): 123-8. doi: 10.1016/j.bbrc.2004.02.022 [19] Mu H, Wang X, Lin P, et al. Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation[J]. Biochim Biophys Acta, 2008, 1783(9): 1576-84. doi: 10.1016/j.bbamcr.2008.04.004 [20] Xu ZZ, Wang M, Wang YJ, et al. Effect of nitrotyrosine on renal expressions of NF-kappaB, MCP-1 and TGF-beta1 in rats with diabetic nephropathy[J]. Nan Fang Yi Ke Da Xue Xue Bao, 2013, 33: 346-50. [21] Julius U, Drel VR, Grässler J, et al. Nitrosylated proteins in monocytes as a new marker of oxidative-nitrosative stress in diabetic subjects with macroangiopathy[J]. Exp Clin Endocrinol Diabetes, 2009, 117(2): 72-7. doi: 10.1055/s-2008-1078710 [22] Shao N, Kuang HY, Wang N, et al. Relationship between Oxidant/Antioxidant Markers and Severity of Microalbuminuria in the Early Stage of Nephropathy in Type 2 Diabetic Patients[Z]. 2013: 232404. [23] Lee W, Wang C, Lee H. Antioxidants in decelerating diabetic nephropathy[Z]. 2013. [24] Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications[J]. Circ Res, 2010, 106(8): 1319-31. doi: 10.1161/CIRCRESAHA.110.217117 [25] Ceriello A, Quagliaro L, D'amico M, et al. Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat[J]. Diabetes, 2002, 51(4): 1076-82. doi: 10.2337/diabetes.51.4.1076
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