Research on e-TRACKING evaluate endothelial function in type 2 diabetes
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摘要:
目的使用血管回声跟踪技术（e-TRACKING）评价2型糖尿病患者内皮细胞损害，探讨与糖化血红蛋白的关系。 方法选择健康人群30人，2型糖尿病中血糖控制正常14例，血糖控制不正常16例，评价患者动脉硬化指标，压力应变弹性参数系数（Eр）、僵硬度（β）、顺应性（AC）、脉搏波传导速度（PWVβ）、膨大指数（AI）之间的差异，比较与糖化血红蛋白之间的关系，判断糖尿病患者动脉粥样硬化程度和HA1c之间的关系。 结果（1）与正常对照组相比，糖尿病组的颈总动脉β、Eр、PWVβ均增高，差异有统计学意义；而AC降低，差异有统计学意义，AI增高，差异无明显差异；（2）与糖化血红蛋白正常组相比，糖化血红蛋白增高组的颈总动脉β、Eр、PWVβ均增高，差异有统计学意义；而AC降低，差异有统计学意义，AI增高，但差异无明显差异。 结论2型糖尿病患者使用血管回声跟踪技术可以评价早期动脉硬化程度，有助于早期治疗，延缓动脉粥样硬化的进展。 Abstract:Objective Using E-TRACKING (E-TRACKING) evaluation of endothelial cell damage in type 2 diabetic patients, to explore the relationship between glycated hemoglobin. Methods 30 healthy people, blood glucose control in type 2 diabetes normal in 14 cases, 16 cases of abnormal glucose control, evaluation of patients with arteriosclerosis index, pressure-strain elastic parameters coefficient (Eр), stiffness (β), compliance (AC), pulse wave velocity (PWVβ) differences swelling index (AI) between comparing the relationship between glycated hemoglobin and determine atherosclerosis in diabetic patients and HA1c relationship between the degree of hardening. Results ① Compared with normal control group, the common carotid artery β diabetic group, Eр, PWVβ were increased, the difference was statistically significant; while AC decreased significantly, AI increased, no significant difference in differences. ② Compared with the normal group, glycated hemoglobin, glycated hemoglobin carotid artery increased β group, Eр, PWVβ were increased, the difference was statistically significant; while AC decreased significantly, AI increased, but there was no significant difference in differences. Conclusion The patients with type 2 diabetes can be evaluated eTRACKING early atherosclerosis extent, contribute to early treatment of atherosclerosis progress slow. -
Key words:
- Type 2-Diabete /
- E-Tracking Technology /
- Carotid Artery /
- HbA1c
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表 1 正常对照组与糖尿病组颈动脉弹性参数比较(x±s)
分 组 Eр(Kpa) β PWVβ(m/s) AI(%) Ac(mm2/Kpa) 正常对照组 98.27±33.35 8.46±2.99 5.99±0.95 9.38±13.13 0.83±0.32 糖尿病组 172.77±34.10 12.73±3.90 7.94±1.29 10.46±9.58 0.59±0.21 t 8.55 4.76 6.63 0.36 3.53 P <0.01 <0.01 <0.01 >0.05 <0.01 
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表 2 HbA1c正常组与HbA1c增高组颈动脉弹性参数比较(x±s)
分 组 Eр(Kpa) β PWVβ(m/s) AI(%) AC HbA1c正常组 155.93±29.88 11.15±2.17 7.39±0.78 9.49±11.47 0.66±0.21 HbA1c增高组 187.50±31.28 14.53±4.67 8.56±1.50 11.31±7.88 0.50±0.18 t 2.82 2.59 2.72 0.51 2.16 P <0.05 <0.05 <0.05 >0.05 <0.05
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