Clinical research of injury of small intestinal mucosa induced by non-steroidal anti-inflammatory drugs
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摘要: 目的探讨非甾体类消炎药（NSAID）对小肠黏膜的损害情况。方法选取行胶囊内镜检查的76例患者，其中40例因各种病因长期服用阿司匹林等NSAID（观察组），未服用阿司匹林等药物者36例（对照组）；观察组中，服用阿司匹林（100 mg/d）28例，服用其他NSAID患者12例。观察分析小肠黏膜出血、糜烂以及溃疡等情况。结果观察组中发生小肠黏膜损害23例（57.50%），对照组为9例（11.11%），两组比较有统计学意义（P<0.01）；服用阿司匹林组中发生小肠黏膜损害为16例（57.14%），服用其他NSAID组发生小肠黏膜损害7例（58.33%），两组比较无统计学意义（P>0.01）。结论长期服用NSAID对小肠黏膜损害的发生率明显高于未服用该类药物者，不同类别的NSAID对小肠黏膜的损害无差别。Abstract: Objective To investigate the injury of small intestinal mucosa induced by Non-steroidal Anti-inflammatory Drugs (NSAID). Method 76 cases of capsule endoscopy were divided into the observation group and the control group. The observation group included 40 patients with long-term use of aspirin (28 cases, 100 mg/d) and other NSAID (12 cases) for various causes. The patients in the control group did not take any NSAID. To observe and analyse intestinal mucosal bleeding, erosion and ulcer, etc. Results 23 cases of small intestinal mucosal damage occurred in the observation group (57.50%), and 7 cases also occurred in the control group (11.11%), the incidence of small intestinal mucosal damage in two groups was statistically significant different (P<0.01), However, it showed no significant difference in the aspirin group and in the other group with other NSAID (P>0.01). Conclusion long-term administration of NSAID can cause damage to the small intestinal mucosa, different types of NSAID similarly damage to the intestinal mucosa.
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Key words:
- NSAID /
- Small intestinal mucosa /
- capsule endoscopy
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表 1 各组患者小肠黏膜损伤情况
Table 1. small intestinal mucosal damage in each group
组别 n 小肠黏膜损伤(例) 未发生小肠黏膜损伤(例) 发生率 观察组 40 23 17 57.50%a 阿司匹林组 28 16 12 57.14%c 非阿司匹林组 12 7 5 58.33%d 对照组 36 4 32 11.11%b a与b比较，χ2=7.80，χ0.05,12=3.84，P<0.05, c与d比较，χ2=0.00，χ0.05,12=3.84，P>0.05 
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