Evaluation of the efficaay of rectal cancer after chemotherapy by texture analysis based on magnetic resonance T2 weighted images
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摘要:
目的 通过磁共振T2加权图像的纹理分析评估直肠癌化疗后疗效的价值。 方法 选取我院2019年1月~2021年4月经临床与病理明确诊断的直肠癌患者117例，分为完全缓解组（n=38）和非完全缓解组（n=79）；受试者化疗前和治疗结束后均采用3.0T MRI扫描；采用Omni Kineitics软件提取受试者纹理特征，计算纹理特征的峰度、方差、熵和能量参数；绘制ROC曲线分析磁共振T2加权图像的纹理，评估直肠癌化疗后病理完全缓解的价值。 结果 治疗后完全缓解组受试者方差、熵明显低于未完全缓解组（1534±312 vs 2312±586、5.43±0.41 vs 6.42±0.29）峰度、能量明显高于未完全缓解组（4.85±0.66 vs 3.72±0.49、0.016±0.002 vs 0.013±0.02），差异有统计学意义（P < 0.05）。 结论 采用磁共振T2加权图像的纹理分析可评估化疗后的疗效，并可预测直肠癌化疗后病理完全缓解情况。 Abstract:Objective To evaluate the efficacy of rectal cancer after chemotherapy by texture analysis of magnetic resonance T2-weighted images. Methods A total of 117 patients with rectal cancer who were clinically and pathologically diagnosed in our hospital from January 2019 to April 2021. The patients were divided into complete remission group (n=38) and incomplete remission group (n=79), they were scanned with 3.0T MRI before and after chemotherapy. Omni Kineitics software was used to extract texture features of subjects, and the kurtosis, variance, entropy and energy parameters of texture features were calculated. ROC curves were drawn to analyze the texture of magnetic resonance T2-weighted images, and the rectal value of pathological complete response after cancer chemotherapy. Results After treatment, the variance and entropy of the subjects in the complete remission group were significantly lower than those in the incomplete remission group (1534±312 vs 2312±586, 5.43±0.41 vs 6.42±0.29), the kurtosis and energy were significantly higher than those in the incomplete remission group (4.85±0.66 vs 3.72±0.49, 0.016±0.002 vs 0.013±0.02), and the difference was statistically significant (P < 0.05). Conclusion Texture analysis using magnetic resonance T2-weighted images can evaluate the efficacy of chemotherapy and predict the pathological complete response of rectal cancer after chemotherapy. -
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