Correlation of MSCT imaging findings of lung adenocarcinoma with CEA and CA125
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摘要:
目的研究肺腺癌MSCT影像学表现与血清癌胚抗原(CEA)、糖类抗原125(CA125)的相关性。 方法选取2018年6月~ 2021年2月我院收治的94例肺腺癌患者作为研究对象。所有患者入院后均接受多层螺旋CT扫描(MSCT),分析患者影像学特征,包括肿瘤边缘(毛刺征、分叶征)、肿瘤内部征象(空气支气管征、空泡征和囊腔样改变)、肿瘤周围结构征象(胸膜凹陷征、血管集束征),同时采用化学发光法检测患者血清CEA、CA125水平并与患者MSCT影像学表现进行相关性分析。 结果94例患者均接受MSCT检查发现,毛刺征58例、分叶征69例、空气支气管征9例、空泡征8例、血管集束征13例、胸膜凹陷征60例、囊腔样改变3例;CEA水平与患者MSCT影像学毛刺征、分叶征、空泡征、囊腔样改变和胸膜凹陷征的差异具有统计学意义(P < 0.05);CA125与患者MSCT影像学毛刺征、分叶征、空泡征、囊腔样改变和胸膜凹陷征的差异具有统计学意义(P < 0.05)。 结论肺腺癌的MSCT影像学表现毛刺征、分叶征、空泡征、囊腔样改变和胸膜凹陷征与患者CEA、CA125水平具有相关性。 Abstract:ObjectiveTo explore the correlation between MSCT imaging findings of lung adenocarcinoma and CEA and CA125. MethodsA total of 94 patients with lung adenocarcinoma admitted to our hospital from June 2018 to February 2021 were selected. All patients acceptted multislice CT scanning (MSCT). The imaging features of patients with package including the tumor edge (burr), Ye Zheng, tumor signs, air bronchogram, cavitation and cystic cavity change, the structure of the tumor around sign, pleural indentation, blood vessels, cluster were analyzed. The serum CEA and CA125 level were analyzed by using chemiluminescence detection, and its correlation with MSCT imaging findings was analyzed. ResultsAll the 94 patients underwent MSCT examination. We found that 58 patients had burr sign, 69 patients had lobulation sign, 9 patients had air bronchial sign, 8 patients had vacuolation sign, 13 patients had vascular cluster sign, 60 patients had pleural depression sign, and 3 patients had cystic cavity like change. CEA was significantly different with MSCT imaging burr sign, lobulation sign, vacuole sign, cystoid change and pleural depression sign (P < 0.05). CA125 was significantly different with MSCT imaging burr sign, lobulation sign, vacuole sign, cystoid change and pleural depression sign (P < 0.05). ConclusionMSCT imaging manifestations of lung adenocarcinoma include burr sign, lobulation sign, vacuole sign, cystoid change and pleural depression, which are correlated with CEA and CA125 levels. -
Key words:
- lung adenocarcinoma /
- MSCT /
- imaging /
- CEA /
- CA125 /
- Correlation
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表 1 患者MSCT检查结果
Table 1. MSCT examination results of patients
组别 例数 占比(%) 毛刺征 58 64.89 分叶征 69 55.31 空气支气管征 9 51.06 空泡征 8 55.31 囊腔样改变 3 51.06 胸膜凹陷征 60 64.89 血管集束征 3 3.19 表 2 CEA与患者MSCT影像学表现相关性分析
Table 2. Correlation analysis between CEA and MSCT imaging manifestations of patients (Mean±SD)
MSCT表现 CEA水平(U/mL) t P 毛刺征 8.101 < 0.001 存在(n=58) 16.87±3.10 不存在(n=36) 11.58±3.04 分叶征 7.066 < 0.001 存在(n=69) 17.44±3.05 不存在(n=25) 12.40±3.07 空气支气管征 0.227 0.820 存在(n=9) 10.40±3.11 不存在(n=85) 10.14±3.27 空泡征 6.195 < 0.001 存在(n=8) 19.29±3.05 不存在(n=86) 11.54±3.41 囊腔样改变 3.478 < 0.001 存在(n=3) 17.20±3.57 不存在(n=91) 10.71±3.17 胸膜凹陷征 9.696 < 0.001 存在(n=60) 18.09±3.24 不存在(n=34) 11.42±3.14 血管集束征 0.713 0.301 存在(n=13) 12.08±3.01 不存在(n=81) 11.42±3.11 表 3 CA125与患者MSCT影像学表现相关性分析
Table 3. Correlation analysis between CA125 and MSCT imaging manifestations of patients (Mean±SD)
MSCT表现 CA125水平(U/mL) t P 毛刺征 10.903 < 0.001 存在(n=58) 48.23±5.14 不存在(n=36) 36.25±5.24 分叶征 4.143 < 0.001 存在(n=69) 43.18±5.98 不存在(n=25) 37.52±5.47 空气支气管征 0.342 0.732 存在(n=9) 35.48±5.77 不存在(n=85) 36.14±5.47 空泡征 3.504 < 0.001 存在(n=8) 43.29±5.57 不存在(n=86) 36.54±5.18 囊腔样改变 2.113 0.037 存在(n=3) 42.20±5.05 不存在(n=91) 35.95±5.04 胸膜凹陷征 7.780 < 0.001 存在(n=60) 45.18±5.34 不存在(n=34) 36.42±5.07 血管集束征 0.518 0.605 存在(n=13) 36.22±5.07 不存在(n=81) 35.42±5.18 -
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