Efficacy of neuroacid combined with flunarizine hydrochloride capsules in the treatment of cognitive impairment caused by leukoaraiosis
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摘要:
目的探讨分析神经酸联合盐酸氟桂利嗪胶囊对脑白质疏松所致认知功能障碍的疗效。 方法选取86例脑白质疏松所致认知功能障碍患者并将其按照随机数表分为常规组和联合组，43例/组。常规组采用单纯盐酸氟桂利嗪胶囊治疗，联合组给予神经酸联合盐酸氟桂利嗪胶囊治疗。对比2组基线资料，治疗前后认知功能变化，临床疗效，不良反应发生率。 结果联合组基线资料与常规组均相近，差异无统计学意义（P>0.05）；治疗前联合组与常规组视空间与执行、注意、命名、语言、抽象、延迟记忆、定向维度蒙特利尔认知评估量表（MoCA）评分与总分相近（P>0.05），治疗后联合组注意、语言、抽象、延迟记忆方面的MoCA评分与总分均高于治疗前（P < 0.05）；联合组在注意、抽象、以及MoCA总分方面临床疗效分布与常规组对比差异有统计学意义（86.05% vs 58.14%，P < 0.05）；联合组不良反应发生率（11.63%）与常规组（6.98%）相近（P>0.05），且患者均可耐受。 结论对脑白质疏松所致认知功能障碍患者给予神经酸联合盐酸氟桂利嗪胶囊治疗可改善其认知功能，增强疗效，且安全可靠。 Abstract:ObjectiveTo explore and analyze the effect of neuroacid combined with Flunarizine Hydrochloride Capsule on cognitive impairment caused by leukoaraiosis. MethodsEighty-six patients with cognitive impairment caused by leukoaraiosis were selected and randomly divided into routine group and combined group, 43 cases in each group.The routine group was treated with flunarizine hydrochloride capsule alone.The combined group was treated with nerve acid and Flunarizine Hydrochloride capsules.The baseline data of the two groups were compared. The changes of cognitive function, clinical efficacy before and after treatment and incidence of adverse reactions were compared. ResultsThe baseline data of the combined group were similar to those of the routine group (P>0.05). Before treatment, the scores of visual space and execution, attention, naming, language, abstraction, delayed memory and orientation dimension Montreal Cognitive Assessment Scale (MoCA) were similar to those of the routine group (P>0.05), but after treatment, the scores of MoCA in the combined group were higher than those before treatment (P < 0.05), and after treatment, the above dimensions of MoCA in the combined group were higher than those before treatment (P < 0.05). The scores and total scores were higher than those of the routine group (P < 0.05). The clinical efficacy distribution of the combined group was significantly different from that of the routine group (P < 0.05). The total effective rate of the former group was 86.05%, which was significantly higher than that of the latter group (58.14%) (P < 0.05). The incidence of adverse reactions in the combined group was 11.63%, which was similar to 6.98% in the routine group (P>0.05), and the patients were tolerable. ConclusionNeuric acid combined with flunarizine hydrochloride capsules can improve the cognitive function and enhance the curative effect of patients with cognitive impairment caused by leukoaraiosis, which is safe and reliable. -
表 1 2组患者的基线资料对比
Table 1. Comparison of baseline data between the two groups [n=43, n(%)]
指标 联合组 常规组 t/Z/χ2 P 性别 0.187 0.665 男 24 (55.81) 22 (51.16) 女 19 (44.19) 21 (48.84) 年龄（岁, Mean±SD） 66.29±10.18 67.27±10.22 0.445 0.657 脑白质疏松分级 0.244 0.621 1级 9 (20.93) 9 (20.93) 2级 11 (25.58) 13 (30.23) 3级 13 (30.23) 12 (27.91) 4级 10 (23.26) 9 (20.93) 受教育年限（年） 0.205 0.651 < 12 16 (37.21) 14 (32.56) ≥12 27 (62.79) 29 (67.44) 
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表 2 治疗前后认知功能变化对比
Table 2. Comparison of cognitive function before and after treatment (Score, n=43, Mean±SD)
指标 联合组 t P 常规组 t P 治疗前 治疗后 治疗前 治疗后 视空间与执行 2.05±0.41 3.05±0.44 5.955 0.087 2.00±0.38 2.51±0.40 0.587 0.559 注意 1.98±0.32 3.16±0.42 6.703 0.007 2.00±0.35 2.56±0.41 0.277 0.783 命名 2.02±0.39 3.19±0.50 0.825 0.331 1.98±0.40 2.53±0.39 0.470 0.640 语言 2.00±0.35 3.00±0.46 5.171 0.000 1.95±0.36 2.47±0.49 4.653 0.016 抽象 1.98±0.37 3.07±0.52 5.950 0.040 1.95±0.35 2.44±0.46 0.386 0.700 延迟记忆 2.00±0.36 2.93±0.44 3.726 0.000 1.91±0.37 2.56±0.48 1.143 0.036 定向 1.98±0.39 2.95±0.46 3.764 0.055 2.00±0.40 2.56±0.50 0.235 0.815 总分 14.37±2.15 21.72±3.80 5.349 0.000 14.12±2.17 17.95±2.63 0.537 0.593
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表 3 临床疗效对比
Table 3. Clinical efficacy comparison [n=43, n(%)]
组别 显效 有效 无效 总有效率 联合组 14（32.56） 23（53.49） 6（13.95） 37（86.05） 常规组 6（13.95） 19（44.19） 18（41.86） 25（58.14） Z/χ2 9.602 8.323 P 0.001 0.004
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