Clinical observation of short-term Mometasone Furoate Nasal Spray combined with saline wash in patients with chronic sinusitis after functional endoscopic sinus surgery
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摘要:
目的探讨功能性鼻内窥镜术后慢性鼻-鼻窦炎伴鼻息肉患者短期糠酸莫米松盐水盥洗的疗效。 方法选择功能性鼻内窥镜术的慢性鼻-鼻窦炎伴鼻息肉患者86例，采用随机数字表法将其分为观察组和对照组，每组43例。观察组术后给予糠酸莫米松盐水盥洗，对照组术后给予生理盐水盥洗及糠酸莫米松鼻喷剂喷鼻。比较两组患者术前的VAS评分和Kennedy评分；比较两组患者术后3 d和盥洗治疗后的LKES评分和SNOT22评分；分析两组患者的不良反应发生情况。 结果两组患者术前VAS评分、Kennedy评分的比较，差异无统计学意义（P>0.05）。两组患者盥洗治疗后的LKES评分、SNOT评分均低于术后3 d，差异有统计学意义（P < 0.05）；观察组盥洗治疗后的LKES评分（5.07±0.82分）与SNOT评分（13.41±0.74分）低于对照组，差异有统计学意义（P < 0.05）。观察组有1例患者术后出现鼻腔活动性出血，给予压迫止血处理后可止血。两组其余患者均未见明显不良反应发生，均可顺利完成本研究治疗方案。 结论功能性鼻内窥镜术后慢性鼻-鼻窦炎伴鼻息肉患者短期糠酸莫米松盐水盥洗有助于鼻黏膜的恢复，更好缓解患者临床症状。 -
关键词:
- 功能性鼻内窥镜术 /
- 慢性鼻-鼻窦炎伴鼻息肉 /
- 糠酸莫米松 /
- 盐水盥洗
Abstract:ObjectiveTo investigate the efficacy of short-term mometasone furoate nasal spray combined with saline lavage in patients with chronic sinusitis after functional nasal endoscopy. MethodsEighty-six patients with chronic sinusitis with functional nasal endoscopy were selected. They were randomly divided into observation group and control group, with 43 cases in each group. After the operation, the control group was given a saline wash and mometasone furoate nasal spray, while the observation group was given a wash of mometasone furoate. The vas and Kennedy scores of the two groups were compared before operation. LKES and SNOT22 scores of the two groups were compared 3 days after operation and after lavatory treatment. The adverse reactions of the two groups were analyzed. ResultsThe difference of VAS score and Kennedy score between the two groups was not significant (P>0.05). The LKES score and SNOT score of the two groups were significantly lower than those of the three days after the operation (P < 0.05). The LKES score and SNOT score of the observation group were lower than that of the control group (PP < 0.05). In the observation group, there was 1 case of active bleeding in the nasal cavity after operation, which could be stopped after compression and hemostasis. The other patients in the two groups did not have any obvious adverse reactions. It could successfully complete the treatment plan. ConclusionShort-term washing with mometasone furoate in patients with chronic rhionosinusitis with nasai polyps after functional nasal endoscopy can help the recovery of nasal mucosa and better alleviate the clinical symptoms of patients. -
表 1 两组患者术前VAS评分和Kennedy评分的比较（分, n=43, Mean±SD）
Table 1. Comparison of VAS score and Kennedy score of two groups
组别 VAS评分 Kennedy评分 观察组 17.73±3.15 3.42±1.03 对照组 18.14±3.31 3.39±1.07 t 0.112 0.107 P 0.783 0.842 
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表 2 两组患者LKES评分、SNOT评分的比较（分, n=43, Mean±SD）
Table 2. Comparison of LKES score and SNOT score of two groups
组别 时间 LKES评分 SNOT评分 观察组 术后3 d 15.95±0.68 24.02±1.37 盥洗治疗后 5.07±0.82*# 13.41 ± 0.74*# 对照组 术后3 d 15.04±0.75 24.06±1.42 盥洗治疗后 9.79±1_12* 17.21±1_50* *P < 0.05 vs术后3 d; #P < 0.05 vs对照组.
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