FMRI study of motor, sensory and speech-related brain areas in healthy middle-aged and elderly women after the first intervention of international standard scalp acupuncture
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摘要:
目的运用静息态脑功能成像（fcMRI）技术，探讨在健康中老年女性人群中施行头针组穴针刺后脑区激活的情况。 方法本研究于2017年1~5月招募11例已自愿签署知情同意书的健康中老年女性志愿者，年龄60~63岁（56.18±3.82岁），于顶中线、左侧顶颞前斜线和顶颞后斜线施行头针刺激。针刺前、后采用西门子3.0 T超导MRI获取受试者的fcMRI数据，并基于Matlab 2012a平台，使用DPABI、SPM12和Rest1.8工具包进行数据分析和作图，以低频振幅比率和局部一致性（ReHo）作为结局指标。 结果最终10例受试者接受国际标准头针干预后脑局部活动变化如下：以右侧小脑后叶、小脑角、悬雍垂和山坡为主的脑区低频振幅比率降低（T= −6.576 1），而以左侧角回、楔前叶和BA7为主的脑区低频振幅比率增强（T= 6.219 3）。以左梭形回（T= −5.609 5）为主,以左侧脑桥（T= −6.431 6）为主，以颞上回和海马旁回（T= −6.442 4）为主，以右侧距状裂周围皮层（T= −5.520 1）为主和以右侧梭形回（T= −6.477 6）为主的脑区ReHo降低，而双侧楔前叶和BA7、角回为主（T= 4.822 4、5.606 4），左颞中回和颞上回为主（T= 6.745 8），左顶下小叶和中央后回为主（T= 8.089 1），左边缘叶、扣带回、辅助运动区、中央前回、中央后回（T= 6.714 1）为主的脑区ReHo增强。 结论健康中老年女性脑功能在国际标准头针首次干预后，与感觉、肢体运动、言语功能相关的脑区出现特异性改变。 -
关键词:
- 静息态脑功能成像技术 /
- 国际标准头针 /
- 经穴特异性
Abstract:ObjectiveTo investigate the activation of brain regions after international standard scalp acupuncture on healthy middle-aged and elderly women using resting state brain functional imaging (Rs-fMRI). MethodsWe recruited 11 healthy middle-aged and elderly female volunteers who had voluntarily signed informed consent from January 2017 to May 2017, with the age from 60 to 63 years old (average 56.18±3.82). They had voluntarily signed informed consent were recruited to receive scalp acupuncture stimulation at MS5, the left MS6, and the left MS7. Rs-fMRI data of subjects were obtained by Siemens 3.0 t superconducting MRI before and after acupuncture. It was based on Matlab 2012a platform, using DPABI、SPM12 and REST1.8 software for data analysis and mapping with fractional amplitude low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) as an outcome indicator. ResultsFinally, the changes of local brain activity after the international standard scalp acupuncture intervention in ten subjects were as follows: fALFF decreased at the right posterior cerebellar lobe, cerebellopontine angle, uvula and declive (T= −6.576 1), and increased at the left angular gyrus, precuneus and BA7 (T= 6.219 3). ReHo decreased at mainly the left spindle gyrus (T= −5.609 5), and the land the left pontine (T= −6.431 6), and mainly the superior temporal gyrus (BA38) and para hippocampus (T= −6.442 4), and decreased at Cortical cortex (T=−5.520 1) and right fusiform gyrus (T= −6.477 6) as well, but increased at the bilateral anterior wedge, BA7, and angular gyrus (T=4.822 4 and 5.606 4), the left middle temporal superior and superior temporal gyrus (BA21, BA22) are increased (T= 6.745 8), and increased at mainly the left top parietal lobe and central posterior gyrus (T= 8.089 1) are increased, and the left marginal lobe, cingulate gyrus (BA24), auxiliary sports area, central anterior gyrus (BA4), central posterior gyrus (BA3) (T= 6.714 1) are increased too. ConclusionBrain function in healthy middle-aged and elderly women shows specific changes in brain areas related to sensory, motor and speech functions after the first intervention with the international standard scalp acupuncture. -
图 1 国际标准头针首次干预后fALFF变化的脑区
Figure 1. Brain regions of fALFF after first intervention of international standard scalpel
图 2 国际标准头针首次干预后ReHo变化的脑区
Figure 2. Brain regions and the location of ReHo after first intervention of international standard scalpel
表 1 国际标准头针首次干预后fALFF和ReHo变化的脑区及其定位
Table 1. Brain regions and the location of fALFF and ReHo after first intervention of international standard scalpel
参数 脑区效应 脑区 MiNi坐标 激活强度（T） X Y Z fALFF 降低 右小脑后叶、小脑中脚、悬雍垂和山坡 15 −84 −36 −6.576 1 增强 左角回、楔前叶、BA7 −36 −75 45 6.219 3 ReHo 降低 右距状裂周围皮层 33 −72 3 −5.520 1 降低 右梭形回 48 −33 −30 −6.477 6 降低 左梭形回 −39 −33 −12 −5.609 5 降低 左脑桥 −3 −15 −51 −6.431 6 降低 左颞上回、海马旁回 −36 −3 −18 −6.442 4 增强 左颞中回和颞上回 −57 −9 −3 6.745 8 增强 左顶下小叶和中央后回 −33 −39 39 8.089 1 增强 左边缘叶、扣带回、辅助运动区、
中央前回、中央后回−18 −12 48 6.714 1 增强 左角回、BA7、楔前叶 −39 −72 51 4.822 4 增强 右楔前叶、BA7 18 −78 48 5.606 4 X、Y、Z代表脑空间定位轴，分别表示在MiNi标准化空间坐标系中左右，前后和上下方位的坐标位置. 
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