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ceRNAs在结直肠癌中的研究进展

段巧斌,  俞金龙

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文章导航 > 分子影像学杂志  > 2018 >  41(4): 499-503
段巧斌, 俞金龙. ceRNAs在结直肠癌中的研究进展[J]. 分子影像学杂志, 2018, 41(4): 499-503. doi: 10.12122/j.issn.1674-4500.2018.04.18
引用本文: 段巧斌, 俞金龙. ceRNAs在结直肠癌中的研究进展[J]. 分子影像学杂志, 2018, 41(4): 499-503. doi: 10.12122/j.issn.1674-4500.2018.04.18
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Qiaobin DUAN, Jinlong YU. Progress of CeRNAs in colorectal cancer[J]. Journal of Molecular Imaging, 2018, 41(4): 499-503. doi: 10.12122/j.issn.1674-4500.2018.04.18
Citation: Qiaobin DUAN, Jinlong YU. Progress of CeRNAs in colorectal cancer[J]. Journal of Molecular Imaging, 2018, 41(4): 499-503. doi: 10.12122/j.issn.1674-4500.2018.04.18
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ceRNAs在结直肠癌中的研究进展

doi: 10.12122/j.issn.1674-4500.2018.04.18

  • 南方医科大学珠江医院，广东 广州 510280

基金项目: 广东省自然科学基金（2017A030313533）
详细信息
    作者简介:

    段巧斌，硕士研究生，E-mail: 1451914664@qq.com

    通讯作者:

    俞金龙，主任医师，教授，硕士生导师，E-mail: yujinlong640506@163.com

Progress of CeRNAs in colorectal cancer

  • Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China

    摘要
  • 摘要: 结直肠癌在我国乃至全球范围发生率和死亡率都居于前列，严重危害着人体的健康，虽然结直肠癌的诊断和治疗技术不断提高，但中晚期结直肠癌患者的生存期仍然不佳，因此需要深入理解结直肠癌的发生发展机制，竞争内源性RNA理论的提出加深了对肿瘤形成机制的理解。竞争内源性RNA理论认为假基因转录本、长链非编码RNA、环状RNA、mRNA能作为竞争性内源性RNA，它们拥有编码蛋白mRNA相同microRNA反应元件，能竞争结合microRNA的结合位点，影响功能蛋白的表达而发挥促癌或抑癌的作用。近来大量研究表明竞争性内源性RNA分子在结直肠癌恶性行为中发挥重要功能，因此有必要对这些研究进行归纳梳理，本文目的在于将这些在结直肠癌中研究的竞争性内源性RNA分子进行归类，并阐述这些分子在结直肠癌中的作用。

     

    Abstract: Colorectal cancer has a high morbidity and mortality both in China and world, which seriously endangers human health. Although the diagnosis and treatment techniques for colorectal cancer have been improved, the survival time of patients with advanced colorectal cancer is still poor. It is necessary to understand the mechanism of colorectal cancer. The competing endogenous RNA theory has deepened the understanding of the mechanism of tumor formation. The competing endogenous RNA (ceRNA) theory points out that psedugenic RNA、LncRNA、circRNA、mRNA, harbouring miRNA response element (MRE). It can act as ceRNA by competing for shared miRNAs to regular protein expression and promote/inhibit cancer. Recently, a large number of studies have shown that ceRNA molecules play an important role in the malignant behavior of colorectal cancer. It is necessary to summarize these studies. The purpose of this paper is to classify these ceRNA molecules in colorectal cancer and to elaborate the functions of these molecules in colorectal cancer.

     

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    • 参考文献(55)
  • [1] Franco-Zorrilla JM, Valli A, Todesco M, et al. Target mimicry provides a new mechanism for regulation of microRNA activity[J]. Nat Genet, 2007, 39(8): 1033-7 doi: 10.1038/ng2079
    [2] Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells[J]. Nat Methods, 2007, 4(9): 721-6 doi: 10.1038/nmeth1079
    [3] Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language[J]. Cell, 2011, 146(3): 353-8 doi: 10.1016/j.cell.2011.07.014
    [4] Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition[J]. Nature, 2014, 505(7483): 344-52 doi: 10.1038/nature12986
    [5] Qi X, Zhang DH, Wu N, et al. ceRNA in cancer: possible functions and clinical implications[J]. J Med Genet, 2015, 52(10): 710-8 doi: 10.1136/jmedgenet-2015-103334
    [6] Karreth FA, Pandolfi PP. ceRNA cross-talk in cancer: when ce-bling rivalries go awry[J]. Cancer Discov, 2013, 3(10): 1113-21 doi: 10.1158/2159-8290.CD-13-0202
    [7] Favoriti P, Carbone G, Greco M, et al. Worldwide burden of colorectal cancer: a review[J]. Updates Surg, 2016, 68(1): 7-11 doi: 10.1007/s13304-016-0359-y
    [8] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2): 115-32 doi: 10.3322/caac.21338
    [9] Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(3): 177-82 doi: 10.3322/caac.v67.3
    [10] 中华人民共和国卫生和计划生育委员会医政医管局, 中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2015版)[J]. 中华消化外科杂志, 2015, 14(10): 783-99 doi: 10.3760/cma.j.issn.1673-9752.2015.10.001
    [11] 蔡国响, 戴卫星, 蔡三军. 结直肠癌多学科综合治疗的现状与未来[J]. 中华胃肠外科杂志, 2016, 19(6): 607-11 doi: 10.3760/cma.j.issn.1671-0274.2016.06.002
    [12] Tan JY, Marques AC. Chapter three - the miRNA-Mediated Cross-Talk between transcripts provides a novel layer of posttranscriptional regulation[J]. Adv Genet, 2014, 85(8): 149-99
    [13] Volinia S, Galasso M, Costinean S, et al. Reprogramming of miRNA networks in cancer and leukemia[J]. Genome Res, 2010, 20(5): 589-99 doi: 10.1101/gr.098046.109
    [14] Thomson DW, Dinger ME. Endogenous microRNA sponges: evidence and controversy[J]. Nat Rev Genet, 2016, 17(5): 272-83 doi: 10.1038/nrg.2016.20
    [15] LI XJ, GUO AM, JI LJ, et al. Pseudogene in cancer: real functions and promising signature[J]. J Med Genet, 2015, 52(1): 17-24 doi: 10.1136/jmedgenet-2014-102785
    [16] Dunham I, Kundaje A, Aldred SF, et al. An integrated encyclopedia of DNA elements in the human genome[J]. Nature, 2012, 489(7414): 57-74 doi: 10.1038/nature11247
    [17] Pink RC, Wicks K, Caley DP, et al. Pseudogenes: Pseudo-functional or key regulators in health and disease[J]. Rna, 2011, 17(5): 792-98 doi: 10.1261/rna.2658311
    [18] Poliseno L, Salmena L, Zhang J, et al. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology[J]. Nature, 2010, 465(7301): 1033-8 doi: 10.1038/nature09144
    [19] Yu G, Yao W, Gumireddy K, et al. Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear-cell renal cell carcinoma progression[J]. Mol Cancer Ther, 2014, 13(12): 3086-97 doi: 10.1158/1535-7163.MCT-14-0245
    [20] Gao L, Ren W, Zhang L, et al. PTENp1, a natural sponge of miR-21, mediates PTEN expression to inhibit the proliferation of oral squamous cell carcinoma[J]. Mol Carcinog, 2017, 56(4): 1322-34 doi: 10.1002/mc.v56.4
    [21] Li RK, Gao J, Guo LH, et al. PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer[J]. Cancer Gene Ther, 2017, 24(7): 309-15 doi: 10.1038/cgt.2017.29
    [22] Ye X, Fan F, Bhattacharya R, et al. VEGFR-1 pseudogene expression and regulatory function in human colorectal cancer cells[J]. Mol Cancer Res, 2015, 13(9): 1274-82 doi: 10.1158/1541-7786.MCR-15-0061
    [23] Guttman M, Rinn JL. Modular regulatory principles of large non-coding RNAs[J]. Nature, 2012, 482(7385): 339-46 doi: 10.1038/nature10887
    [24] Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease[J]. Cell Mol Life Sci, 2016, 73(13): 2491-509 doi: 10.1007/s00018-016-2174-5
    [25] Yang W, Ning N, Jin X. The lncRNA H19 promotes cell proliferation by competitively binding to miR-200a and derepressing β-Catenin expression in colorectal cancer[J]. Biomed Res Int, 2017, 24(7): 2767484-93
    [26] Lian YF, Xu YT, Xiao CX, et al. The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN[J]. Scientific Reports, 2017, 32(7): 332-9
    [27] Guttman M, Rinn JL. Modular regulatory principles of large non-coding RNAs[J]. Nature, 2012, 482(7385): 339-46
    [28] Han D, Wang M, Ma N, et al. Long noncoding RNAs: Novel players in colorectal cancer[J]. Cancer Letters, 2015, 361(1): 13-21 doi: 10.1016/j.canlet.2015.03.002
    [29] Schmitt AM, Chang HY. Long Noncoding RNAs in cancer Pathways[J]. Cancer Cell, 2016, 29(4): 452-63 doi: 10.1016/j.ccell.2016.03.010
    [30] Yang W, Ning N, Jin X. The lncRNA H19 promotes cell proliferation by competitively binding to miR-200a and derepressing beta-Catenin expression in colorectal cancer[J]. Biomed Res Int, 2017, 20(7): 2767484-9
    [31] Bian ZH, Jin LG, Zhang JW, et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p[J]. Scientific Reports, 2016, 29(6): 602-11
    [32] Chen DL, Chen LZ, Lu YX, et al. Long noncoding RNA XIST expedites metastasis and modulates epithelial-mesenchymal transition in colorectal cancer[J]. Cell Death Dis, 2017, 8(8): e3011-5 doi: 10.1038/cddis.2017.421
    [33] Chen DL, Lu YX, Zhang JX, et al. Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression[J]. Theranostics, 2017, 7(19): 4836-49 doi: 10.7150/thno.20942
    [34] Gao HY, Song XD, Kang T, et al. Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer[J]. Oncotargets and Therapy, 2017, 10(2): 205-16
    [35] Han P, Li JW, Zhang BM, et al. The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/beta-catenin signaling[J]. Molecul Cancer, 2017, 16(4): 412-20
    [36] Huang GL, Wu XL, Li S, et al. The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer[J]. Scientific Reports, 2016, 23(6): 602-9
    [37] Xu J, Zhao J, Zhang R. The Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in colorectal cancer[J]. Cellul Physiol Biochem, 2017, 41(2): 635-44 doi: 10.1159/000457938
    [38] Liu ML, Zhang Q, Yuan X, et al. Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer[J]. World J Gastroenterol, 2018, 24(9): 1004-12 doi: 10.3748/wjg.v24.i9.1004
    [39] Guo JU, Agarwal V, Guo HL, et al. Expanded identification and characterization of mammalian circular RNAs[J]. Genome Biol, 2014, 15(7): 409-13 doi: 10.1186/s13059-014-0409-z
    [40] Li Y, Zheng QP, Bao CY, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis[J]. Cell Res, 2015, 25(8): 981-4 doi: 10.1038/cr.2015.82
    [41] Qu S, Yang X, Li X, et al. Circular RNA: A new star of noncoding RNAs[J]. Cancer Lett, 2015, 365(2): 141-8 doi: 10.1016/j.canlet.2015.06.003
    [42] Han B, Chao J, Yao H. Circular RNA and its mechanisms in disease: From the bench to the clinic[J]. Pharmacol Ther, 2018, 187(11): 31-44
    [43] Xie H, Ren X, Xin S, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer[J]. Oncotarget, 2016, 7(18): 26680-91
    [44] Zhang XL, Xu LL, Wang F. Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1[J]. Cell Biol Int, 2017, 41(9): 1056-64 doi: 10.1002/cbin.v41.9
    [45] Zhou YF, Huang GL, Zhu H, et al. cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-Catenin pathway[J]. PLoS One, 2015, 10(6): e0131225-9 doi: 10.1371/journal.pone.0131225
    [46] Guo JN, Li J, Zhu CL, et al. Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer[J]. Onco Targets Ther, 2016, 9(4): 7451-8
    [47] Hsiao KY, Lin YC, Gupta SK, et al. Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis[J]. Cancer Res, 2017, 77(9): 2339-50 doi: 10.1158/0008-5472.CAN-16-1883
    [48] Weng WH, Wei Q, Toden S, et al. Circular RNA ciRS-7-A promising prognostic biomarker and a potential therapeutic target in colorectal cancer[J]. Clinical Cancer Research, 2017, 23(14): 3918-28 doi: 10.1158/1078-0432.CCR-16-2541
    [49] Karreth FA, Tay Y, Perna D, et al. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma[J]. Cell, 2011, 147(2): 382-95 doi: 10.1016/j.cell.2011.09.032
    [50] Tay Y, Kats L, Salmena L, et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs[J]. Cell, 2011, 147(2): 344-57 doi: 10.1016/j.cell.2011.09.029
    [51] Liu K, Guo L, Guo Y, et al. AEG-13'-untranslated region functions as a ceRNA in inducing epithelial-mesenchymal transition of human non-small cell lung cancer by regulating miR-30a activity[J]. Eur J Cell Biol, 2015, 94(1): 22-31 doi: 10.1016/j.ejcb.2014.10.006
    [52] Jeyapalan Z, Deng Z, Shatseva T, et al. Expression of CD443′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis[J]. Nucleic Acids Research, 2011, 39(8): 3026-41 doi: 10.1093/nar/gkq1003
    [53] Yang J, Li T, Gao C, et al. FOXO13′UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity[J]. FEBS Letters, 2014, 588(17): 3218-24 doi: 10.1016/j.febslet.2014.07.003
    [54] Sureban SM, May R, Ramalingam S, et al. Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism[J]. Gastroenterology, 2009, 137(2): 649-59 doi: 10.1053/j.gastro.2009.05.004
    [55] Li D, Yang ZK, Bu JY, et al. OCT4B modulates OCT4A expression as ceRNA in tumor cells[J]. Oncol Rep, 2015, 33(5): 2622-30 doi: 10.3892/or.2015.3862
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  • 收稿日期:  2018-06-07
  • 刊出日期:  2018-11-01

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