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Volume 41 Issue 2
May  2018
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Article Navigation >  Journal of Molecular Imaging  > 2018  >  41(2): 271-273
Xiushan CHEN, Zhipeng ZHONG, Qiaohuan LI, Ke LI. Effects of DPP4 inhibitor and long-acting insulin therapy on blood biochemical indexes of type 2 diabetes: a comparative study[J]. Journal of Molecular Imaging, 2018, 41(2): 271-273. doi: 10.3969/j.issn.1674-4500.2018.02.32
Citation: Xiushan CHEN, Zhipeng ZHONG, Qiaohuan LI, Ke LI. Effects of DPP4 inhibitor and long-acting insulin therapy on blood biochemical indexes of type 2 diabetes: a comparative study[J]. Journal of Molecular Imaging, 2018, 41(2): 271-273. doi: 10.3969/j.issn.1674-4500.2018.02.32
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Effects of DPP4 inhibitor and long-acting insulin therapy on blood biochemical indexes of type 2 diabetes: a comparative study

doi: 10.3969/j.issn.1674-4500.2018.02.32

  • Department of Endocrinology, Second People's Hospital of Shunde, Foshan 528305, China

  • Received Date: 2018-02-14
  • Publish Date: 2018-04-01
    Abstract
  • Objective To investigate the effects of DPP4 inhibitor and long-acting insulin therapy on blood biochemical indexes of type 2 diabetes. Methods 440 cases of type 2 diabetes patients in our department from January 2017 to July 2018 were included and divided into DPP4 group (Saxagliptin) and long-acting insulin group (insulin glargine). All patients received corresponding drugs for 3 months, after which the serum blood glucose, blood lipid, blood insulin and insulin resistance index of each group were detected and recorded. Result Blood glucose was well controlled in both groups, and there was no significance between the control degrees(F=1.296, P=0.578). However, the insulin resistance index of the DPP4 group was significant lower than that of the long-acting insulin group (t=8.11, P<0.05). Compare to long-acting insulin, DPP4 inhibitor improve insulin sensitivity. The level of triglyceride (TG) of DPP4 group was significantly higher than that of the long-acting insulin group, while the level of highly density lipoprotein cholesterol (HDLC) of DPP4 group was significantly lower than that of its counterpart (P<0.05). indicating that DPP4 inhibitor is better at regulating the level of TG and HDLC. There was no significant difference in the level of total cholesterol (TC), very low density lipoprotein cholesterol (vLDL-C) and low density lipoprotein cholesterol (LDLC) between two groups(P>0.05). Conclusion DPP4 inhibitor, as a new drug used for type 2 diabetes, can effectively regulate the blood glucose and blood lipid and increase the insulin sensibility.

     

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