PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester

Yueping LI; Qingfeng YAN; Chunxia HU; song JIN; Huo FU; Wuli LI

doi:10.3969/j.issn.1674-4500.2018.02.19

Volume 41 Issue 2

May 2018

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Article Navigation > Journal of Molecular Imaging > 2018 > 41(2): 219-223

Yueping LI, Qingfeng YAN, Chunxia HU, song JIN, Huo FU, Wuli LI. PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester[J]. Journal of Molecular Imaging, 2018, 41(2): 219-223. doi: 10.3969/j.issn.1674-4500.2018.02.19

Citation:

Yueping LI, Qingfeng YAN, Chunxia HU, song JIN, Huo FU, Wuli LI. PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester[J]. Journal of Molecular Imaging, 2018, 41(2): 219-223. doi: 10.3969/j.issn.1674-4500.2018.02.19

Citation:

Yueping LI, Qingfeng YAN, Chunxia HU, song JIN, Huo FU, Wuli LI. PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester[J]. Journal of Molecular Imaging, 2018, 41(2): 219-223. doi: 10.3969/j.issn.1674-4500.2018.02.19

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PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester

doi: 10.3969/j.issn.1674-4500.2018.02.19

1.
Department of Basic Medicine and Life Science
2.
The First Affiliated Hospital of Hainan Medical College, Haikou 571199, China

Received Date: 2018-02-23
Publish Date: 2018-04-01

Abstract

Abstract

Objective To evaluate the predictive value of PAPP-A, INH-A, β-hCG and uterine artery pulsatility (PI) for preeclampsia at the early stage of second trimester. Methods The prospective nested case-control study was carried out. Serum samples of 416 pregnant women were obtained at 11～12⁺6 weeks of the gestation. PAPP-A, INH-A and β-hCG concentrations were measured by chemiluminescence method or enzyme-linked immunosorbent assay (ELISA), while uterine artery pulsatility index (PI) was measured by Doppler velocimetry at the same time. Results 23 pregnant women who were found to have developed preeclampsia were used as the preeclampsia group (PE group), and the other 393 cases whose blood pressure remained normal were chosen as the control group. The incidence of PE was 5.52%. The MOM values of PAPP-A, β-hCG, INH-A and PI in PE group were significantly different from the control group(P< 0.05).The logistic regression showed that age and PI have no significant effect on the prediction of PE. Among the relative factors, PAPP-A and INH-A are two factors that are negatively correlated with the occurrence of PE, while β-HCG is a positive factor. Comparing these predictive factors individually, the ranking in terms of predictive ability is following: PAPP-A>β-hCG>INH-A. The predictive ability for PE was significantly improved when PAPP-A, INH-A and β-hCG were combinedly used, and the area under the ROC curve can reach to 0.867. Conclusion Combining the screening of different biomarkers, such as serum PAPP-A, INH-A and β-hCG, could increase the predictive value of PE at the early stage of second-trimester.
- preeclampsia,
- combined prediction,
- early stage of second-trimester

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References

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PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester

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PAPP-A, INH-A, β-hCG and uterine artery pulsatility index for the prediction of preeclampsia at the early second trimester

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