Research status of erectile dysfunction pharmacotherapy

Zhicheng GONG; Yi ZUO; Yiyang ZHONG; Shanchao ZHAO

doi:10.3969/j.issn.1674-4500.2018.02.16

Volume 41 Issue 2

May 2018

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Zhicheng GONG, Yi ZUO, Yiyang ZHONG, Shanchao ZHAO. Research status of erectile dysfunction pharmacotherapy[J]. Journal of Molecular Imaging, 2018, 41(2): 201-206. doi: 10.3969/j.issn.1674-4500.2018.02.16

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Zhicheng GONG, Yi ZUO, Yiyang ZHONG, Shanchao ZHAO. Research status of erectile dysfunction pharmacotherapy[J]. Journal of Molecular Imaging, 2018, 41(2): 201-206. doi: 10.3969/j.issn.1674-4500.2018.02.16

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Research status of erectile dysfunction pharmacotherapy

doi: 10.3969/j.issn.1674-4500.2018.02.16

1.
Department of Urology, Nanfang Hospital/The First School of Clinical Medicine of Southern Medical University, Guangzhou 510515, China
2.
Department of Urology, The Sixth People's Hospital of Guangzhou Panyu,Guangzhou 511422,China

Received Date: 2018-03-02
Publish Date: 2018-04-01

Abstract

Abstract

Although oral phosphodiesterase-5 (PDE5) inhibitors and androgen therapy are common treatments for erectile dysfunction (ED), some patients respond poorly to these drugs because of ED’s multiple pathogenic mechanisms. Many researchers have tried to find new treatment strategies, and targeted therapy alternatives include the central and peripheral pathways. Centrally acting agents include melanocortin receptor agonists, dopaminergic agonists and clavulanic acid (paclitaxel), while peripherally acting agents include soluble guanylate cyclase activators and Rho kinase inhibitor. Proteotherapy and gene therapy regenerate damaged erectile tissues by rejuvenating or regenerating cavernous endothelial cells and cavernous nerves or by inhibiting the fibrosis of tissues secondary to neurovascular dysfunction. This article reviews the PDE5 inhibitor therapy and androgen therapy, and introduces clinical and preclinical ED pharmacotherapy strategies, the results of which have laid a solid foundation for future clinical applications.
- erectile dysfunction,
- pharmacotherapy,
- preclinical studies

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References(59)

References

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Research status of erectile dysfunction pharmacotherapy

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