x
Volume 41 Issue 2
May  2018
Turn off MathJax
Article Contents
Article Navigation >  Journal of Molecular Imaging  > 2018  >  41(2): 196-200
Bowen JIANG, Ke HAN. Progress in the myocardial protective strategies research[J]. Journal of Molecular Imaging, 2018, 41(2): 196-200. doi: 10.3969/j.issn.1674-4500.2018.02.15
Citation: Bowen JIANG, Ke HAN. Progress in the myocardial protective strategies research[J]. Journal of Molecular Imaging, 2018, 41(2): 196-200. doi: 10.3969/j.issn.1674-4500.2018.02.15
shu

Progress in the myocardial protective strategies research

doi: 10.3969/j.issn.1674-4500.2018.02.15

  • Binzhou Medical College, Yantai 264003,China

  • Received Date: 2018-02-06
  • Publish Date: 2018-04-01
    Abstract
  • Myocaridial protection aims to salvage myocardium from ischemia and reperfusion injury and to reduce infarct size and its consequences. After more than 30 years of development, the concept of ischemic preconditioning has evolved into ‘ischemic conditioning’, a term that encompasses a number of related endogenous cardioprotective strategies, which can be applied either directly to the heart (ischemic preconditioning or postconditioning) or from afar, for example to a limb (remote ischemic preconditioning, preconditioning, or postconditioning). A variety of cardioprotective therapies have shown promising results in reducing infarct size and improving clinical outcomes in patients with ischemic heart disease.

     

    • FullText(HTML)
  • loading
    • References(51)
  • [1]
    Cabrera-Fuentes H, Aragones J, Bernhagen J, et al. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"[J]. Basic Res Cardiol, 2016, 111(6): 69-75. doi: 10.1007/s00395-016-0586-x
    [2]
    Xia Z, Li H, Irwin MG. Myocardial ischaemia reperfusion injury:the challenge of translating ischaemic and anaesthetic protection from animal models to humans[J]. Br J Anaesth, 2016,11(7): 44-62. https://academic.oup.com/bja/article/117/suppl_2/ii44/2237262
    [3]
    Marber MS, Latchman DS, Walker JM, et al. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction[J]. Circulation, 1993, 88(3): 1264-72. doi: 10.1161/01.CIR.88.3.1264
    [4]
    Hausenloy DJ, Yellon DM. The second window of preconditioning(SWOP)where are we now[J]. Cardiovasc Drugs Ther, 2010, 24(3): 235-54. doi: 10.1007/s10557-010-6237-9
    [5]
    Hausenloy DJ, Yellon DM. Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection[J]. Heart Fail Rev, 2007, 12(3/4): 217-34. doi: 10.1007/s10741-007-9026-1
    [6]
    Hausenloy DJ, Lecour S, Yellon DM. Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signaling pathways in ischemic postconditioning: two sides of the same coin[J]. Antioxid Redox Signal, 2011, 14(5): 893-907. doi: 10.1089/ars.2010.3360
    [7]
    Hausenloy DJ, Barrabes JA, Botker HE, et al. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery[J]. Basic Res Cardiol, 2016, 111(6): 70-8. doi: 10.1007/s00395-016-0588-8
    [8]
    Varga ZV, Giricz Z, Bencsik P, et al. Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification[J]. Curr Drug Targets, 2015, 16(8): 904-11. doi: 10.2174/1389450116666150427154203
    [9]
    Williams RP, Manou-Stathopoulou V, Redwood SR, et al. 'Warm-up Angina': harnessing the benefits of exercise and myocardial ischaemia[J]. Heart, 2014, 100(2): 106-14. doi: 10.1136/heartjnl-2013-304187
    [10]
    Di LF, Bernardi P. Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole[J]. Cardiovasc Res, 2006, 70(2): 191-9. doi: 10.1016/j.cardiores.2006.01.016
    [11]
    Walsh SR, Tang TY, Kullar P, et al. Ischaemic preconditioning during cardiac surgery:systematic review and meta-analysis of perioperative outcomes in randomised clinical trials[J]. Eur J Cardiothorac Surg, 2008, 34(5): 985-94. doi: 10.1016/j.ejcts.2008.07.062
    [12]
    Zhao ZQ. Postconditioning in reperfusion injury: a status report[J]. Cardiovasc Drugs Ther, 2010, 24(3): 265-79. doi: 10.1007/s10557-010-6240-1
    [13]
    Hausenloy DJ. Cardioprotection techniques: preconditioning,postconditioning and remote conditioning(basic science) [J].Curr Pharm Des, 2013, 19(25): 4544-63. doi: 10.2174/1381612811319250004
    [14]
    Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart[J]. Circulation, 2005, 112(14): 2143-8. doi: 10.1161/CIRCULATIONAHA.105.558122
    [15]
    Halestrap AP, Richardson AP. The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury[J]. J Mol Cell Cardiol, 2015, 78(12): 129-41. https://www.sciencedirect.com/science/article/pii/S002228281400265X
    [16]
    Araszkiewicz A, Grygier M, Pyda MA, et al. Postconditioning reduces enzymatic infarct size and improves microvascular reperfusion in patients with ST-Segment elevation myocardial infarction[J]. Cardiology, 2014, 129(4): 250-7. doi: 10.1159/000367965
    [17]
    Liu BS, Xu F, Wang JL, et al. The cardioprotection of ischemic postconditioning in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention[J]. Int J Cardiol, 2015, 178(6): 181-3.
    [18]
    Luo WJ, Li B, Lin GQ, et al. Postconditioning in cardiac surgery for tetralogy of Fallot[J]. J Thorac Cardiovasc Surg, 2007, 133(5): 1373-4. doi: 10.1016/j.jtcvs.2007.01.028
    [19]
    Sivaraman V, Mudalagiri NR, Di Salvo CA, et al. Postconditioning protects human atrial muscle through the activation of the RISK pathway[J]. Basic Res Cardiol, 2007, 102(5): 453-9. doi: 10.1007/s00395-007-0664-1
    [20]
    Eitel I, Stiermaier T, Rommel KP, et al. Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized Lipsia Conditioning trial[J]. Eur Heart J, 2015, 36(44, SI): 3049-55. doi: 10.1093/eurheartj/ehv463
    [21]
    Roolvink V, Ottervanger JP, Ibáñez B, et al. One year clinical outcome of early administration of intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary reperfusion[J]. EuroIntervention, 2017,72(4):125-34.
    [22]
    Cung TT, Morel O, Cayla G, et al. Cyclosporine before PCI in Patients with Acute Myocardial Infarction[J]. N Engl J Med, 2015, 373(11): 1021-31. doi: 10.1056/NEJMoa1505489
    [23]
    Kitakaze M, Asakura M, Kim J, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction(J-WIND):two randomised trials[J]. Lancet, 2007, 370(9597): 1483-93. doi: 10.1016/S0140-6736(07)61634-1
    [24]
    Woo JS, Kim W, Ha SJ, et al. Cardioprotective effects of exenatide in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of exenatide myocardial protection in revascularization study[J]. Arterioscler Thromb Vasc Biol, 2013, 33(9): 2252-60. doi: 10.1161/ATVBAHA.113.301586
    [25]
    Chang G, Liu J, Qin S, et al. Cardioprotection by exenatide:A novel mechanism via improving mitochondrial function involving the GLP-1 receptor/cAMP/PKA pathway[J]. Int J Mol Med, 2017,36(10):248-53. doi: 10.3892/ijmm.2017.3318
    [26]
    Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes[J]. N Engl J Med, 2015, 373(22): 2117-28. doi: 10.1056/NEJMoa1504720
    [27]
    Baartscheer A, Schumacher CA, Wust RC, et al. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits[J]. Diabetologia, 2017, 60(3): 568-73. doi: 10.1007/s00125-016-4134-x
    [28]
    Kleinbongard P, Skyschally A, Heusch G. Cardioprotection by remote ischemic conditioning and its signal transduction[J]. Pflugers Arch, 2017, 469(2): 159-81. doi: 10.1007/s00424-016-1922-6
    [29]
    Hausenloy DJ, Yellon DM. Remote ischaemic preconditioning: underlying mechanisms and clinical application[J]. Cardiovasc Res, 2008, 79(3): 377-86. doi: 10.1093/cvr/cvn114
    [30]
    Rassaf T, Totzeck M, Hendgen-Cotta UB, et al. Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning[J]. Circ Res, 2014, 114(10): 1601-10. doi: 10.1161/CIRCRESAHA.114.303822
    [31]
    Li J, Rohailla S, Gelber N, et al. MicroRNA-144 is a circulating effector of remote ischemic preconditioning[J]. Basic Res Cardiol, 2014, 109(5): 423-33. doi: 10.1007/s00395-014-0423-z
    [32]
    Davidson SM, Selvaraj P, He D, et al. Remote ischaemic preconditioning involves signalling through the SDF-1 alpha/CXCR4 signalling axis[J]. Basic Res Cardiol, 2013, 108(5): 377-82. doi: 10.1007/s00395-013-0377-6
    [33]
    Shimizu M, Tropak M, Diaz RJ, et al. Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection[J]. Clin Sci (Lond), 2009, 117(5): 191-200. doi: 10.1042/CS20080523
    [34]
    Wang L, Oka N, Tropak M, et al. Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocardial performance after neonatal cardioplegic arrest[J]. J Thorac Cardiovasc Surg, 2008, 136(2): 335-42. doi: 10.1016/j.jtcvs.2007.12.055
    [35]
    Steensrud T, Li J, Dai X, et al. Pretreatment with the nitric oxide donor SNAP or nerve transection blocks humoral preconditioning by remote limb ischemia or intra-arterial adenosine[J]. Am J Physiol Heart Circ Physiol, 2010, 299(5): H1598-603. doi: 10.1152/ajpheart.00396.2010
    [36]
    Redington KL, Disenhouse T, Strantzas SC, et al. Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors[J]. Basic Res Cardiol, 2012, 107(2): 241-7. doi: 10.1007/s00395-011-0241-5
    [37]
    Redington KL, Disenhouse T, Li J, et al. Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors[J]. J Physiol Sci, 2013, 63(3): 219-23. doi: 10.1007/s12576-013-0259-6
    [38]
    Jensen RV, Støttrup NB, Kristiansen SB, et al. Release of a humoral circulating cardioprotective factor by remote ischemic preconditioning is dependent on preserved neural pathways in diabetic patients[J]. Basic Res Cardiol, 2012, 107(5): 285-9. doi: 10.1007/s00395-012-0285-1
    [39]
    Günaydin B, Cakici I, Soncul H, et al. Does remote organ ischaemia trigger cardiac preconditioning during coronary artery surgery[J]. Pharmacol Res, 2000, 41(4): 493-6. doi: 10.1006/phrs.1999.0611
    [40]
    Cheung MM, Kharbanda RK, Konstantinov IE, et al. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans[J]. J Am Coll Cardiol, 2006, 47(11): 2277-82. doi: 10.1016/j.jacc.2006.01.066
    [41]
    Thielmann M, Kottenberg E, Kleinbongard P, et al. Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial[J]. Lancet, 2013, 382(9892): 597-604. doi: 10.1016/S0140-6736(13)61450-6
    [42]
    Candilio L, Malik A, Ariti C, et al. Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial[J]. Heart, 2015, 101(3): 185-92. doi: 10.1136/heartjnl-2014-306178
    [43]
    Hong DM, Lee EH, Kim HJ, et al. Does remote ischaemic preconditioning with postconditioning improve clinical outcomes of patients undergoing cardiac surgery? Remote Ischaemic Preconditioning with Postconditioning Outcome Trial[J]. Eur Heart J, 2014, 35(3): 176-84. doi: 10.1093/eurheartj/eht346
    [44]
    Meybohm P, Bein B, Brosteanu O, et al. A multicenter trial of remote ischemic preconditioning for heart surgery[J]. N Engl J Med, 2015, 373(15): 1397-407. doi: 10.1056/NEJMoa1413579
    [45]
    Hausenloy DJ, Candilio L, Evans R, et al. Remote ischemic preconditioning and outcomes of cardiac surgery[J]. N Engl J Med, 2015, 373(15): 1408-17. doi: 10.1056/NEJMoa1413534
    [46]
    Hoole SP, Heck PM, Sharples L, et al. Cardiac remote ischemic preconditioning in coronary stenting (CRISP stent) study: a prospective, randomized control trial[J]. Circulation, 2009, 119(6): 820-7. doi: 10.1161/CIRCULATIONAHA.108.809723
    [47]
    Liu Z, Wang YL, Xu D, et al. Late remote ischemic preconditioning provides benefit to patients undergoing elective percutaneous coronary intervention[J]. Cell Biochem Biophys, 2014, 70(1): 437-42. doi: 10.1007/s12013-014-9936-1
    [48]
    Bosnjak ZJ, Ge ZD. The application of remote ischemic conditioning in cardiac surgery[J]. F1000Res, 2017,23(6): 928-35. https://f1000researchdata.s3.amazonaws.com/manuscripts/11880/1bcb2540-a992-4fd7-8b67-81f33079ff57_11018_-_zeljko_bosnjak.pdf?doi=10.12688/f1000research.11018.1
    [49]
    Kanazawa H, Tseliou E, Malliaras KA, et al. Cellular postconditioning allogeneic Cardiosphere-Derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in Pigs with acute myocardial infarction[J]. Circ Heart Fail, 2015, 8(2): 322-32. doi: 10.1161/CIRCHEARTFAILURE.114.001484
    [50]
    de Couto G, Liu WX, Tseliou E, et al. Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction[J]. J Clin Invest, 2015, 125(8): 3147-62. doi: 10.1172/JCI81321
    [51]
    Kloner RA. Current state of clinical translation of cardioprotective agents for acute myocardial infarction[J]. Circ Res, 2013, 113(4): 451-63. doi: 10.1161/CIRCRESAHA.112.300627
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (1329) PDF downloads(11) Cited by()
    Proportional views
    Related
    • Copyright © 2013《Journal of Molecular Imaging》 Editorial Office ICP备00000000号
    • Key tip: Adobe Reader6 The full text may be displayed abnormally，Please upgrade to Adobe Reader7Or higher .
    • Address: 1838 North Guangzhou Dadao, Guangzhou City, Guangdong Province, China Tel: 020-61648176 E-mail: 

    Supported by: Beijing Renhe Information Technology Co. Ltd  support: info@rhhz.net

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return