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Volume 41 Issue 2
May  2018
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Article Navigation >  Journal of Molecular Imaging  > 2018  >  41(2): 157-160
Jing XIAO, Li JIANG. Clinical and MRI features of mitochondrial encephalomyopathy patients with seizure as the main clinical manifestation[J]. Journal of Molecular Imaging, 2018, 41(2): 157-160. doi: 10.3969/j.issn.1674-4500.2018.02.05
Citation: Jing XIAO, Li JIANG. Clinical and MRI features of mitochondrial encephalomyopathy patients with seizure as the main clinical manifestation[J]. Journal of Molecular Imaging, 2018, 41(2): 157-160. doi: 10.3969/j.issn.1674-4500.2018.02.05
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Clinical and MRI features of mitochondrial encephalomyopathy patients with seizure as the main clinical manifestation

doi: 10.3969/j.issn.1674-4500.2018.02.05

  • First Affiliated Hospital of Sun Yat-senUniversity, Guangzhou 510080, China

  • Received Date: 2018-02-08
  • Publish Date: 2018-04-01
    Abstract
  • Objective To explore the clinical and brain MRI features of mitochondrial encephalomyopathy（ME）with seizure as the main clinical manifestation, so as to improve the accuracy of the diagnosis. Methods The clinical data and brain MRI findings of 7 cases with clinically diagnosed ME with seizure as the main clinical manifestation were analyzed retrospectively. Results Among the 7 cases, 3 were male and 4 were female, age ranging from 13~39 years old. All patients had history of long-term recurrence of limbs’ convulsion, one had blurred vision and one had debility; the lactate level elevated in 6 cases, and brain MRI showed cerebral hemisphere involvement in all cases, wherein 6 patients suffered from bilateral cerebral hemisphere involvement, 4 cases involved both cortical and subcortical white matter, and bilateral basal ganglia and right cerebellar hemisphere were involved in 1 case, causing the formation of transformation foci and brain atrophy. The multivoxel proton MRS examination findings of 5 patients showed lactate peak in the lesion area, the diffusion weighted imaging of 5 cases showed mild restricted diffusion, and the enhanced scan findings of 2 patients showed gyrus-like enhancement in the cortex of the lesion area. Conclusion The clinical and brain MRI features of ME patients with epilepsy as the main symptom are not typical, and is easy to be confused with other diseases. Comprehensive analysis of the history, simple lactate exercise test result and brain MRI finding is helpful to improve the diagnosis of the disease.

     

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