Versatility of pyruvate kinase M2 in tumor cells

Mingxiu GUAN; Minghua GUAN; Yingchao ZHANG; Yunli ZHOU; Dayong ZHENG; Baozhan WANG

doi:10.3969/j.issn.1674-4500.2017.03.27

Volume 40 Issue 3

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Mingxiu GUAN, Minghua GUAN, Yingchao ZHANG, Yunli ZHOU, Dayong ZHENG, Baozhan WANG. Versatility of pyruvate kinase M2 in tumor cells[J]. Journal of Molecular Imaging, 2017, 40(3): 350-353. doi: 10.3969/j.issn.1674-4500.2017.03.27

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Mingxiu GUAN, Minghua GUAN, Yingchao ZHANG, Yunli ZHOU, Dayong ZHENG, Baozhan WANG. Versatility of pyruvate kinase M2 in tumor cells[J]. Journal of Molecular Imaging, 2017, 40(3): 350-353. doi: 10.3969/j.issn.1674-4500.2017.03.27

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Versatility of pyruvate kinase M2 in tumor cells

doi: 10.3969/j.issn.1674-4500.2017.03.27

1.
Department of Clinical Laboratory, Tianjin Baodi Hospital Affiliated to Tianjin Medical University, Tianjin 301800, China
2.
Department of Breast Surgery
3.
Department of Clinical Laboratory, Affiliated Cancer Hospital of Tianjin Medical University, Tianjin 300060,China

Received Date: 2017-03-05
Publish Date: 2017-07-01

Abstract

Abstract

Pyruvate kinase is a critical rate limiting enzyme in glucose metabolism. It has mainly 4 isozyme forms: L type, R type, M1 type and M2 type. Pyruvate kinase M2 (PKM2) mainly expressed in tumor cells. The metabolism of glucose by tumor cells is mainly accomplished by aerobic glycolysis. During the process, PKM2 plays a key role in the rate limiting enzyme. It regulates the signal transduction in the process of tumor cell proliferation. Pyruvate kinase M2 provides energy and material basis for the proliferation of tumor cells. It can be used as a biomarker for early detection of tumor. The exploration of mechanism of PKM2 in tumor can provide a new way to tumor targeted treatment.
- M2 type pyruvate kinase,
- tumor,
- glycolysis,
- non glycolysis

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References(39)

References

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Versatility of pyruvate kinase M2 in tumor cells

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